Detailed information NTG0930204

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: U4D55_RS06170
• Genome accession: NZ_CP143641
• Coordinates: 1248348..1249394 (+)
• Length: 348 a.a.
• NCBI ID: WP_011275375.1
• Uniprot ID: A0A2A1K920
• Organism: Staphylococcus haemolyticus strain M62.3
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1243348..1254394

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U4D55_RS06145 (U4D55_06145)	map	1244224..1244976 (+)	753	WP_011275369.1	type I methionyl aminopeptidase	-
U4D55_RS06150 (U4D55_06150)	-	1245092..1245901 (-)	810	Protein_1189	SDR family oxidoreductase	-
U4D55_RS06155 (U4D55_06155)	-	1246021..1247025 (-)	1005	Protein_1190	HoxN/HupN/NixA family nickel/cobalt transporter	-
U4D55_RS06160 (U4D55_06160)	-	1247239..1247625 (+)	387	WP_037551139.1	hypothetical protein	-
U4D55_RS06165 (U4D55_06165)	liaF	1247650..1248351 (+)	702	WP_011275374.1	cell wall-active antibiotics response protein LiaF	-
U4D55_RS06170 (U4D55_06170)	vraS	1248348..1249394 (+)	1047	WP_011275375.1	sensor histidine kinase	Regulator
U4D55_RS06175 (U4D55_06175)	vraR	1249384..1250013 (+)	630	WP_011275376.1	two-component system response regulator VraR	Regulator
U4D55_RS06180 (U4D55_06180)	-	1250077..1251288 (-)	1212	WP_011275377.1	YihY/virulence factor BrkB family protein	-
U4D55_RS06185 (U4D55_06185)	-	1251485..1251769 (-)	285	WP_011275378.1	YtxH domain-containing protein	-
U4D55_RS06190 (U4D55_06190)	-	1251775..1252239 (-)	465	WP_049394644.1	low molecular weight protein-tyrosine-phosphatase	-
U4D55_RS06195 (U4D55_06195)	-	1252381..1252590 (+)	210	WP_011275380.1	DUF1128 domain-containing protein	-
U4D55_RS06200 (U4D55_06200)	-	1252604..1253851 (+)	1248	WP_011275381.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40179.58 Da
• Isoelectric Point: 6.0550

>NTDB_id=930204 U4D55_RS06170 WP_011275375.1 1248348..1249394(+) (vraS) [Staphylococcus haemolyticus strain M62.3]
MNHYLRAIGSMLILVYSMLTAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAYKINQQNQWIKS
QIEHAIEGETVGINDQNIELYNETIDLYQTLVPLNQELHRLRMKTQNLTNENYNMNDVKVKKIIENERQRLARELHDSVS
QQLFAASMMLSAIKETKLEAPLDQQIPVLEKMVQESQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVIHDI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQQDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNREDDNNDD

Nucleotide

• Length: 1047 bp

>NTDB_id=930204 U4D55_RS06170 WP_011275375.1 1248348..1249394(+) (vraS) [Staphylococcus haemolyticus strain M62.3]
ATGAACCACTACTTAAGAGCTATCGGTTCAATGCTTATACTAGTTTATAGCATGTTAACCGCGTTCTTATTTATAGATAA
AGTATTTGTTAATATTATCTATTTCCAAGGTATGTTTTATACTCAAATTTTTGGGATACCTGTTTTTCTATTTTTAAATT
TAGTCATCATTTTACTTTGTATTATAGTAGGTTCAATTCTCGCATATAAAATTAATCAACAAAATCAGTGGATTAAGTCG
CAAATTGAGCATGCCATTGAAGGAGAAACAGTAGGTATCAATGATCAAAACATTGAGCTCTATAACGAAACCATAGATCT
TTATCAAACATTAGTTCCTCTAAATCAAGAGTTGCACCGTTTACGAATGAAAACGCAAAACTTAACTAATGAAAATTACA
ATATGAATGATGTCAAAGTTAAGAAAATCATTGAGAATGAACGACAGAGATTAGCTCGCGAGTTACATGACTCTGTAAGT
CAACAACTTTTTGCAGCAAGTATGATGTTATCTGCTATAAAAGAAACAAAATTAGAGGCACCGCTTGATCAACAAATACC
AGTTTTAGAGAAAATGGTTCAGGAATCTCAACTTGAAATGCGCGCATTATTACTTCATTTGAGACCTTTAGGACTAAAAG
ATAAATCACTAGGTGAAGGTATCAAAGATTTAGTTATTGATTTGCAAAAGAAAGTGCCTATGAAAGTCATACACGATATT
CAAGATTTCAAGGTTCCTAAAGGTATAGAAGATCATTTATTTAGAATTACACAAGAGGCTATATCAAATACGTTAAGACA
TTCTAATGGAACTAAAGTCACAGTGGAATTATTTAACCAACAAGATTATCTATTACTTCGAATTCAAGATAATGGTAAGG
GATTCAATGTTGACGAGAAATTAGAACAAAGTTATGGATTAAAAAATATGAGAGAACGCGCATTAGAAATTGGTGCGACA
TTCCATATTGTTTCGTTACCGGATTCTGGAACGAGAATAGAAGTTAAAGCACCATTAAATAGGGAGGATGATAATAATGA
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A2A1K920

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.643	99.713	0.914