Detailed information    

insolico Bioinformatically predicted

Overview

Name   comFA/cflA   Type   Machinery gene
Locus tag   VKP34_RS06745 Genome accession   NZ_CP142358
Coordinates   1313062..1314387 (-) Length   441 a.a.
NCBI ID   WP_136112241.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 6702-99     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1308062..1319387
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP34_RS06735 (VKP34_06735) hpf 1311797..1312345 (-) 549 WP_002988974.1 ribosome hibernation-promoting factor, HPF/YfiA family -
  VKP34_RS06740 (VKP34_06740) - 1312425..1313090 (-) 666 WP_136112242.1 ComF family protein -
  VKP34_RS06745 (VKP34_06745) comFA/cflA 1313062..1314387 (-) 1326 WP_136112241.1 DEAD/DEAH box helicase Machinery gene
  VKP34_RS06750 (VKP34_06750) - 1314442..1315074 (+) 633 WP_002988970.1 YigZ family protein -
  VKP34_RS06755 (VKP34_06755) cysK 1315202..1316143 (+) 942 WP_002991877.1 cysteine synthase A -
  VKP34_RS06760 (VKP34_06760) - 1316161..1316538 (-) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  VKP34_RS06765 (VKP34_06765) - 1316538..1317938 (-) 1401 WP_011054832.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  VKP34_RS06770 (VKP34_06770) - 1317975..1318616 (-) 642 WP_002983671.1 response regulator transcription factor -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 49864.37 Da        Isoelectric Point: 10.0630

>NTDB_id=925444 VKP34_RS06745 WP_136112241.1 1313062..1314387(-) (comFA/cflA) [Streptococcus pyogenes strain 6702-99]
MESIENSYGRLLLENQLPDSARQLAQPLKSVVISRGKMICQRCHYQLDEEARLPSGAYYCRFCLVFGRNQSNKLLYAIPP
MHFPKGNYMVWSGQLTAYQEMISQQLLINMQNQKTTLVHAVTGAGKTEMIYAAIEAVINTGGWVCIASPRVDVCVEVATR
LSQAFSCSICLMHAESLPYQRAPIIVATTHQLLKFHKAFDLLIIDEVDAFPFVNNIQLHYAASQALKEGGAKILLTATST
RTLERKVNKGEVVKLTLARRFHNRPLVIPKFIRSFNLFKMIHRQKLPPKILKYLKKQRKTGYPLLIFLPTIIMAESVTAI
LKELLPAEQIACVSSQSQNRKEDITAFRQGKKTILITTTILERGVTFPQIDVFVLGSHHRVYSSQSLVQIAGRVGRSIDR
PDGTLYFFHEGISKAMLLARKEIKEMNYKGYSHDLSTMSTN

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=925444 VKP34_RS06745 WP_136112241.1 1313062..1314387(-) (comFA/cflA) [Streptococcus pyogenes strain 6702-99]
ATGGAGTCTATTGAAAATAGTTATGGGCGGTTGTTGCTAGAAAACCAGTTACCAGATTCAGCAAGGCAGCTTGCTCAACC
TTTAAAAAGTGTAGTAATATCGAGAGGAAAAATGATTTGTCAACGTTGTCACTATCAGCTTGATGAAGAAGCACGACTGC
CAAGTGGAGCCTATTATTGCCGATTTTGTCTTGTCTTTGGACGAAATCAATCAAATAAATTGCTCTATGCTATCCCACCT
ATGCATTTTCCAAAAGGTAATTATATGGTTTGGAGCGGTCAACTAACTGCTTATCAAGAGATGATTTCCCAACAATTATT
AATCAATATGCAAAATCAAAAAACAACATTAGTTCATGCTGTAACTGGTGCAGGAAAAACAGAAATGATTTATGCTGCGA
TTGAGGCGGTAATTAACACAGGTGGCTGGGTTTGCATTGCCAGCCCAAGAGTAGATGTTTGTGTAGAGGTGGCTACTCGT
TTATCCCAAGCCTTCTCCTGCAGCATCTGTTTAATGCACGCAGAGTCTCTTCCTTATCAAAGAGCTCCTATTATAGTAGC
CACAACGCATCAGCTGCTAAAATTTCACAAGGCTTTTGATCTCTTAATTATTGATGAAGTAGACGCATTCCCTTTTGTAA
ATAATATTCAACTTCATTATGCTGCAAGTCAGGCTTTAAAAGAAGGTGGCGCAAAGATTTTATTAACTGCAACTTCAACT
AGAACTTTAGAAAGAAAGGTAAACAAGGGAGAAGTAGTCAAGCTGACATTGGCGAGACGCTTTCATAATAGGCCATTAGT
TATTCCGAAATTTATAAGAAGTTTTAATCTATTTAAAATGATACATCGGCAAAAACTTCCTCCTAAAATTTTAAAATACT
TAAAAAAACAAAGAAAAACAGGCTATCCCCTTTTAATTTTTCTACCCACTATTATAATGGCAGAATCTGTTACAGCAATC
TTAAAAGAGTTATTGCCCGCCGAACAAATAGCTTGTGTTTCTAGTCAATCACAAAACAGGAAAGAAGATATCACAGCTTT
TCGTCAAGGGAAAAAAACGATTTTAATTACAACAACAATTTTAGAAAGGGGTGTGACATTTCCCCAAATTGATGTTTTTG
TTCTTGGGTCTCATCATCGTGTCTATAGTTCCCAAAGTCTTGTTCAAATTGCTGGACGAGTTGGAAGATCTATAGACAGA
CCAGACGGAACGTTATATTTCTTTCATGAAGGTATCAGTAAAGCAATGCTACTAGCAAGAAAAGAGATTAAAGAAATGAA
TTATAAAGGGTATTCGCATGATCTGTCTACTATGTCAACAAATTAG

Domains

Predicted by InterproScan.

Helicase conserved C-terminal domain (Helicase_C)

(289-396)

DEAD/DEAH box helicase (DEAD)

(98-244)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comFA/cflA Streptococcus pneumoniae Rx1

54.177

95.011

0.515
  comFA/cflA Streptococcus pneumoniae D39

54.177

95.011

0.515
  comFA/cflA Streptococcus pneumoniae R6

54.177

95.011

0.515
  comFA/cflA Streptococcus pneumoniae TIGR4

54.177

95.011

0.515
  comFA/cflA Streptococcus mitis NCTC 12261

52.844

95.692

0.506
  comFA/cflA Streptococcus mitis SK321

51.896

95.692

0.497
  comFA Lactococcus lactis subsp. cremoris KW2

46.867

90.476

0.424
  comFA Latilactobacillus sakei subsp. sakei 23K

39.604

91.61

0.363