Detailed information    

insolico Bioinformatically predicted

Overview

Name   eeP   Type   Regulator
Locus tag   VKP53_RS08110 Genome accession   NZ_CP142354
Coordinates   1634277..1635536 (-) Length   419 a.a.
NCBI ID   WP_011018245.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 6745-99     
Function   processing of ComS (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1579594..1648878 1634277..1635536 within 0


Gene organization within MGE regions


Location: 1579594..1648878
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP53_RS07830 (VKP53_07830) - 1579616..1580389 (+) 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
  VKP53_RS07835 (VKP53_07835) - 1581039..1581326 (+) 288 WP_002988079.1 DNA-damage-inducible protein J -
  VKP53_RS07840 (VKP53_07840) - 1581316..1581651 (+) 336 WP_009880846.1 type II toxin-antitoxin system RelE/ParE family toxin -
  VKP53_RS07845 (VKP53_07845) - 1581749..1582737 (+) 989 Protein_1492 tyrosine-type recombinase/integrase -
  VKP53_RS07850 (VKP53_07850) - 1583105..1583191 (-) 87 WP_227874724.1 type II toxin-antitoxin system RelE/ParE family toxin -
  VKP53_RS07855 (VKP53_07855) - 1583191..1583400 (-) 210 WP_281727034.1 hypothetical protein -
  VKP53_RS07860 (VKP53_07860) - 1583775..1586669 (+) 2895 WP_115230699.1 DNA methyltransferase -
  VKP53_RS07865 (VKP53_07865) - 1586684..1589068 (-) 2385 WP_115230700.1 restriction endonuclease -
  VKP53_RS07870 (VKP53_07870) - 1589052..1589516 (-) 465 WP_227874723.1 hypothetical protein -
  VKP53_RS07875 (VKP53_07875) - 1589743..1590420 (-) 678 Protein_1498 helix-turn-helix domain-containing protein -
  VKP53_RS07880 (VKP53_07880) - 1590423..1591286 (-) 864 WP_326674771.1 ImmA/IrrE family metallo-endopeptidase -
  VKP53_RS07885 (VKP53_07885) - 1591512..1592661 (-) 1150 Protein_1500 ISAs1-like element IS1548 family transposase -
  VKP53_RS07890 (VKP53_07890) - 1593113..1593361 (+) 249 WP_085634384.1 hypothetical protein -
  VKP53_RS07895 (VKP53_07895) - 1593399..1593695 (+) 297 WP_085634385.1 cytoplasmic protein -
  VKP53_RS07900 (VKP53_07900) - 1593714..1594169 (+) 456 WP_326674772.1 conjugal transfer protein -
  VKP53_RS07905 (VKP53_07905) - 1594185..1595864 (+) 1680 WP_115230705.1 FtsK/SpoIIIE domain-containing protein -
  VKP53_RS07910 (VKP53_07910) - 1596085..1597338 (+) 1254 WP_115230706.1 replication initiation factor domain-containing protein -
  VKP53_RS07915 (VKP53_07915) mazE 1597395..1597676 (+) 282 WP_017649870.1 type II toxin-antitoxin system PemI/MazE family antitoxin -
  VKP53_RS07920 (VKP53_07920) - 1597669..1598004 (+) 336 WP_227874721.1 type II toxin-antitoxin system RelE/ParE family toxin -
  VKP53_RS07925 (VKP53_07925) - 1598068..1598298 (+) 231 WP_115230707.1 hypothetical protein -
  VKP53_RS07930 (VKP53_07930) - 1598319..1598870 (+) 552 WP_115230708.1 conjugal transfer protein -
  VKP53_RS07935 (VKP53_07935) - 1598883..1599863 (+) 981 Protein_1510 conjugal transfer protein -
  VKP53_RS07940 (VKP53_07940) - 1599869..1600093 (+) 225 WP_115230710.1 hypothetical protein -
  VKP53_RS07945 (VKP53_07945) - 1600095..1600517 (+) 423 WP_085634393.1 conjugal transfer protein -
  VKP53_RS07950 (VKP53_07950) - 1600530..1603034 (+) 2505 Protein_1513 ATP-binding protein -
  VKP53_RS07955 (VKP53_07955) - 1603049..1604959 (+) 1911 WP_115230711.1 PT domain-containing protein -
  VKP53_RS07960 (VKP53_07960) - 1604946..1605173 (+) 228 WP_115230712.1 hypothetical protein -
  VKP53_RS07965 (VKP53_07965) - 1605192..1606304 (+) 1113 WP_115230713.1 phage tail tip lysozyme -
  VKP53_RS07970 (VKP53_07970) - 1606488..1606733 (+) 246 WP_115230714.1 helix-turn-helix domain-containing protein -
  VKP53_RS07975 (VKP53_07975) - 1606773..1607990 (+) 1218 WP_115230715.1 tyrosine-type recombinase/integrase -
  VKP53_RS07980 (VKP53_07980) rpsI 1608100..1608492 (-) 393 WP_002982716.1 30S ribosomal protein S9 -
  VKP53_RS07985 (VKP53_07985) rplM 1608513..1608959 (-) 447 WP_002982710.1 50S ribosomal protein L13 -
  VKP53_RS07990 (VKP53_07990) - 1609177..1609383 (-) 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
  VKP53_RS07995 (VKP53_07995) - 1609380..1610078 (-) 699 WP_023080151.1 hypothetical protein -
  VKP53_RS08000 (VKP53_08000) - 1610214..1611074 (-) 861 WP_011529009.1 DegV family protein -
  VKP53_RS08005 (VKP53_08005) - 1611171..1611689 (-) 519 WP_011055010.1 NYN domain-containing protein -
  VKP53_RS08010 (VKP53_08010) rlmB 1611693..1612439 (-) 747 WP_010922667.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
  VKP53_RS08015 (VKP53_08015) - 1612486..1613283 (-) 798 WP_326674773.1 hypothetical protein -
  VKP53_RS08020 (VKP53_08020) - 1613479..1613892 (-) 414 WP_109981918.1 Mini-ribonuclease 3 -
  VKP53_RS08025 (VKP53_08025) cysS 1613885..1615228 (-) 1344 WP_011285182.1 cysteine--tRNA ligase -
  VKP53_RS08030 (VKP53_08030) - 1615256..1615486 (-) 231 WP_010922670.1 hypothetical protein -
  VKP53_RS08035 (VKP53_08035) cysE 1615965..1616546 (-) 582 WP_010922671.1 serine O-acetyltransferase -
  VKP53_RS08040 (VKP53_08040) - 1616555..1617307 (-) 753 WP_032465246.1 SseB family protein -
  VKP53_RS08045 (VKP53_08045) pnp 1617300..1619432 (-) 2133 WP_326674774.1 polyribonucleotide nucleotidyltransferase -
  VKP53_RS08050 (VKP53_08050) - 1619712..1620443 (-) 732 WP_115230718.1 transaldolase -
  VKP53_RS08055 (VKP53_08055) - 1620453..1621832 (-) 1380 WP_002994557.1 PTS ascorbate transporter subunit IIC -
  VKP53_RS08060 (VKP53_08060) - 1621859..1622143 (-) 285 WP_002982644.1 PTS sugar transporter subunit IIB -
  VKP53_RS08065 (VKP53_08065) - 1622136..1624196 (-) 2061 WP_115230813.1 BglG family transcription antiterminator -
  VKP53_RS08070 (VKP53_08070) rpsO 1624548..1624817 (-) 270 WP_002982634.1 30S ribosomal protein S15 -
  VKP53_RS08075 (VKP53_08075) - 1624993..1625193 (-) 201 WP_011055018.1 hypothetical protein -
  VKP53_RS08080 (VKP53_08080) - 1625319..1625601 (+) 283 Protein_1539 transcriptional regulator -
  VKP53_RS08085 (VKP53_08085) def 1625703..1626317 (+) 615 WP_002982624.1 peptide deformylase -
  VKP53_RS08090 (VKP53_08090) - 1626351..1626893 (-) 543 WP_023611190.1 NADPH-dependent FMN reductase -
  VKP53_RS08095 (VKP53_08095) - 1627024..1627452 (-) 429 WP_002982615.1 MarR family winged helix-turn-helix transcriptional regulator -
  VKP53_RS08100 (VKP53_08100) - 1627562..1631959 (-) 4398 WP_326674775.1 PolC-type DNA polymerase III -
  VKP53_RS08105 (VKP53_08105) - 1632223..1634079 (-) 1857 WP_009880419.1 proline--tRNA ligase -
  VKP53_RS08110 (VKP53_08110) eeP 1634277..1635536 (-) 1260 WP_011018245.1 RIP metalloprotease RseP Regulator
  VKP53_RS08115 (VKP53_08115) - 1635609..1636403 (-) 795 WP_002982606.1 phosphatidate cytidylyltransferase -
  VKP53_RS08120 (VKP53_08120) - 1636416..1637165 (-) 750 WP_110002877.1 isoprenyl transferase -
  VKP53_RS08125 (VKP53_08125) yajC 1637383..1637748 (-) 366 WP_002988027.1 preprotein translocase subunit YajC -
  VKP53_RS08130 (VKP53_08130) - 1637864..1638211 (-) 348 WP_011529027.1 thioredoxin domain-containing protein -
  VKP53_RS08135 (VKP53_08135) - 1638353..1641850 (-) 3498 WP_326674776.1 pullulanase -
  VKP53_RS08140 (VKP53_08140) - 1642048..1643661 (-) 1614 WP_115230724.1 alpha-glucosidase -
  VKP53_RS08145 (VKP53_08145) - 1643790..1644923 (-) 1134 WP_002993686.1 ABC transporter ATP-binding protein -
  VKP53_RS08150 (VKP53_08150) - 1645221..1646069 (-) 849 WP_115230725.1 helix-turn-helix domain-containing protein -
  VKP53_RS08155 (VKP53_08155) ska 1646409..1647731 (+) 1323 WP_115230726.1 streptokinase -
  VKP53_RS08160 (VKP53_08160) dtd 1647829..1648272 (-) 444 WP_115230727.1 D-aminoacyl-tRNA deacylase -

Sequence

Protein


Download         Length: 419 a.a.        Molecular weight: 45719.46 Da        Isoelectric Point: 9.2387

>NTDB_id=925236 VKP53_RS08110 WP_011018245.1 1634277..1635536(-) (eeP) [Streptococcus pyogenes strain 6745-99]
MLGIITFIIIFGILVIVHEFGHFYFAKKSGILVREFAIGMGPKIFSHVDQGGTLYTLRMLPLGGYVRMAGWGDDKTEIKT
GTPASLTLNEQGFVKRINLSQSKLDPTSLPMHVTGYDLEDQLSITGLVLEETKTYKVAHDATIVEEDGTEIRIAPLDVQY
QNASIGGRLITNFAGPMNNFILGIVVFILLVFLQGGMPDFSSNHVRVQENGAAAKAGLRDNDQIVAINGYKVTSWNDLTE
AVDLATRDLGPSQTIKVTYKSHQRLKTVAVKPQKHAKTYTIGVKASLKTGFKDKLLGGLELAWSGAFTILNALKGLITGF
SLNKLGGPVAMYDMSNQAAQNGLESVLSLMAMLSINLGIFNLIPIPALDGGKILMNIIEAIRRKPIKQETEAYITLAGVA
IMVVLMIAVTWNDIMRVFF

Nucleotide


Download         Length: 1260 bp        

>NTDB_id=925236 VKP53_RS08110 WP_011018245.1 1634277..1635536(-) (eeP) [Streptococcus pyogenes strain 6745-99]
ATGTTAGGAATAATAACCTTTATTATTATTTTTGGTATTTTAGTGATTGTCCATGAATTTGGACATTTCTATTTTGCTAA
AAAATCAGGCATTCTAGTAAGAGAATTTGCCATTGGAATGGGCCCTAAAATTTTTTCTCATGTTGACCAAGGAGGAACTC
TTTATACCTTGAGGATGTTACCCTTGGGCGGTTATGTGCGAATGGCTGGTTGGGGTGATGACAAAACTGAGATCAAAACA
GGTACTCCAGCAAGTTTAACCCTTAATGAGCAAGGTTTTGTTAAGCGCATCAACTTGTCTCAAAGTAAGTTAGACCCAAC
GAGTCTCCCAATGCATGTTACAGGCTATGACTTAGAAGATCAGCTGAGTATTACTGGCTTGGTTTTAGAAGAAACCAAGA
CATATAAGGTCGCTCACGATGCTACTATTGTTGAAGAAGACGGTACTGAGATAAGAATTGCTCCGCTTGATGTTCAATAT
CAAAATGCTAGTATTGGCGGACGTTTAATCACCAATTTTGCAGGTCCCATGAATAATTTTATTTTAGGGATTGTGGTTTT
TATCCTCTTGGTCTTTTTACAAGGTGGGATGCCAGATTTTAGTAGCAATCATGTCCGTGTTCAAGAAAATGGAGCAGCAG
CTAAGGCTGGTCTTCGAGATAATGACCAAATTGTCGCAATTAATGGTTATAAGGTGACTAGCTGGAATGATCTCACTGAG
GCTGTAGACCTTGCAACACGGGATCTAGGCCCGTCACAGACCATTAAGGTCACCTATAAGTCACATCAGCGCTTAAAAAC
GGTGGCTGTGAAACCACAAAAGCATGCAAAGACATACACGATAGGAGTTAAGGCGAGTCTGAAAACAGGATTTAAGGATA
AGCTCTTAGGCGGTCTAGAATTAGCTTGGAGTGGGGCGTTTACTATTTTGAATGCTTTGAAAGGATTGATCACTGGCTTT
AGTCTCAATAAATTAGGTGGACCTGTTGCCATGTATGACATGTCCAATCAGGCTGCTCAAAACGGCTTAGAGTCAGTCTT
ATCTCTTATGGCAATGCTTTCGATCAATTTAGGGATCTTTAACCTGATTCCGATTCCTGCACTTGATGGGGGAAAAATCT
TGATGAATATCATTGAAGCCATTCGTCGCAAGCCTATCAAGCAAGAAACAGAGGCCTATATCACCCTAGCTGGGGTTGCT
ATCATGGTCGTATTGATGATTGCTGTGACATGGAATGATATCATGCGCGTCTTTTTCTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(206-271)

Peptidase family M50 (Peptidase_M50)

(6-405)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  eeP Streptococcus thermophilus LMG 18311

68.571

100

0.687
  eeP Streptococcus thermophilus LMD-9

68.333

100

0.685