Detailed information NTG0925222

Bioinformatically predicted

Overview

• Name: clpX
• Type: Regulator
• Locus tag: VKP53_RS05555
• Genome accession: NZ_CP142354
• Coordinates: 1106488..1107717 (-)
• Length: 409 a.a.
• NCBI ID: WP_111676489.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain 6745-99
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1101488..1112717

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VKP53_RS05535 (VKP53_05535)	rpiA	1101770..1102453 (-)	684	WP_021733827.1	ribose-5-phosphate isomerase RpiA	-
VKP53_RS05540 (VKP53_05540)	-	1102831..1104930 (+)	2100	WP_136076637.1	AAA family ATPase	-
VKP53_RS05545 (VKP53_05545)	-	1104988..1105731 (-)	744	WP_002984942.1	hypothetical protein	-
VKP53_RS05550 (VKP53_05550)	yihA	1105879..1106478 (-)	600	WP_011184414.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
VKP53_RS05555 (VKP53_05555)	clpX	1106488..1107717 (-)	1230	WP_111676489.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
VKP53_RS05560 (VKP53_05560)	-	1108037..1108534 (-)	498	WP_002984955.1	dihydrofolate reductase	-
VKP53_RS05565 (VKP53_05565)	-	1108614..1109453 (-)	840	WP_011017679.1	thymidylate synthase	-
VKP53_RS05570 (VKP53_05570)	-	1109662..1110837 (+)	1176	WP_326674695.1	hydroxymethylglutaryl-CoA synthase	-
VKP53_RS05575 (VKP53_05575)	-	1110824..1112101 (+)	1278	WP_326674696.1	hydroxymethylglutaryl-CoA reductase, degradative	-

Sequence

Protein

• Length: 409 a.a.
• Molecular weight: 45021.46 Da
• Isoelectric Point: 4.5775

>NTDB_id=925222 VKP53_RS05555 WP_111676489.1 1106488..1107717(-) (clpX) [Streptococcus pyogenes strain 6745-99]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIQI
LTEPRNALVKQYQTLLSYDGVELAFDKEALEAIANKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide

• Length: 1230 bp

>NTDB_id=925222 VKP53_RS05555 WP_111676489.1 1106488..1107717(-) (clpX) [Streptococcus pyogenes strain 6745-99]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGGCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCCAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTCCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATTGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTAAACACATCAGATTTGATTCAAATT
TTGACAGAACCAAGAAATGCCCTGGTCAAGCAATATCAGACCCTTCTTTCTTACGATGGCGTCGAATTGGCATTTGATAA
GGAAGCCTTAGAAGCCATTGCCAATAAAGCCATTGAACGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATTGAAGAAA
CGATGTTAGACATTATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (110-305)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (312-391)

• ClpX C4-type zinc finger (zf-C4_ClpX) (12-48)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpX	Streptococcus mutans UA159	89.242	100	0.892
clpX	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	58.603	98.044	0.575