Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   Llc71_RS09880 Genome accession   NZ_AP025520
Coordinates   1962701..1963402 (-) Length   233 a.a.
NCBI ID   WP_011676802.1    Uniprot ID   A0A0M2ZUZ8
Organism   Lactococcus cremoris strain 7-1     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1941738..1964266 1962701..1963402 within 0


Gene organization within MGE regions


Location: 1941738..1964266
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Llc71_RS09755 (Llc71_19560) - 1941738..1942040 (-) 303 WP_014735122.1 CHY zinc finger protein -
  Llc71_RS09760 (Llc71_19570) - 1942061..1943032 (-) 972 WP_011835703.1 biotin--[acetyl-CoA-carboxylase] ligase -
  Llc71_RS09765 - 1943038..1943145 (-) 108 Protein_1910 biotin transporter BioY -
  Llc71_RS09775 - 1944472..1945592 (+) 1121 Protein_1912 IS3 family transposase -
  Llc71_RS09780 (Llc71_19620) - 1945665..1946812 (+) 1148 WP_248536990.1 IS3 family transposase -
  Llc71_RS09785 (Llc71_19630) - 1946977..1947192 (-) 216 WP_010905687.1 DUF1408 domain-containing protein -
  Llc71_RS09790 (Llc71_19640) - 1947297..1947461 (+) 165 WP_161769935.1 hypothetical protein -
  Llc71_RS09795 (Llc71_19650) - 1947458..1947676 (-) 219 WP_015966960.1 hypothetical protein -
  Llc71_RS09800 (Llc71_19670) - 1947832..1948092 (-) 261 WP_021037763.1 hypothetical protein -
  Llc71_RS09805 (Llc71_19680) - 1948108..1948299 (-) 192 WP_021037764.1 hypothetical protein -
  Llc71_RS09810 (Llc71_19690) - 1948592..1948960 (+) 369 WP_046124473.1 XRE family transcriptional regulator -
  Llc71_RS09815 (Llc71_19700) - 1948972..1949559 (+) 588 WP_046124472.1 hypothetical protein -
  Llc71_RS09820 (Llc71_19710) - 1949606..1949902 (+) 297 WP_021037767.1 hypothetical protein -
  Llc71_RS09825 (Llc71_19720) - 1950072..1951040 (+) 969 WP_095345212.1 Abi family protein -
  Llc71_RS09830 (Llc71_19730) - 1951138..1952277 (+) 1140 WP_046124470.1 site-specific integrase -
  Llc71_RS09835 (Llc71_19740) sufB 1952480..1953892 (-) 1413 WP_004255207.1 Fe-S cluster assembly protein SufB -
  Llc71_RS09840 (Llc71_19750) sufU 1953988..1954446 (-) 459 WP_011676796.1 Fe-S cluster assembly sulfur transfer protein SufU -
  Llc71_RS09845 (Llc71_19760) - 1954580..1955062 (-) 483 WP_011835709.1 hypothetical protein -
  Llc71_RS09850 (Llc71_19770) - 1955064..1956281 (-) 1218 WP_011835710.1 cysteine desulfurase -
  Llc71_RS09855 (Llc71_19780) sufD 1956281..1957540 (-) 1260 WP_282569296.1 Fe-S cluster assembly protein SufD -
  Llc71_RS09860 (Llc71_19790) sufC 1957677..1958447 (-) 771 WP_011835712.1 Fe-S cluster assembly ATPase SufC -
  Llc71_RS09865 (Llc71_19810) - 1958711..1959858 (+) 1148 WP_095586744.1 IS3 family transposase -
  Llc71_RS09870 - 1959917..1961301 (+) 1385 WP_171031423.1 IS3 family transposase -
  Llc71_RS09875 (Llc71_19840) - 1961373..1962698 (-) 1326 WP_011676801.1 MraY family glycosyltransferase -
  Llc71_RS09880 (Llc71_19850) mecA 1962701..1963402 (-) 702 WP_011676802.1 adaptor protein MecA Regulator
  Llc71_RS09885 (Llc71_19860) - 1963532..1964266 (-) 735 WP_011835714.1 amino acid ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 233 a.a.        Molecular weight: 27046.46 Da        Isoelectric Point: 4.1802

>NTDB_id=92517 Llc71_RS09880 WP_011676802.1 1962701..1963402(-) (mecA) [Lactococcus cremoris strain 7-1]
MKYEDINENTIKITLSFDDLTDYDIKLSDFFGNQEVIEQFFYELVDELGLENRFGNVGMLTFQIQPFPQGVHMIVHEEAM
LGEGGEIPDDPEEFEELMTGFYNKLNEIGADMARERGITDFKPGLGLPGAKKEEAEHEPDFIYYSIRYDDMMSVLTGIKN
VKFADEESEFYRYDGNFYLVVLDNQKAKGKMHVESTRSRMMEYGEATKMSREFLQEYGECLITTRALDVLRKI

Nucleotide


Download         Length: 702 bp        

>NTDB_id=92517 Llc71_RS09880 WP_011676802.1 1962701..1963402(-) (mecA) [Lactococcus cremoris strain 7-1]
ATGAAGTATGAGGATATAAATGAAAACACTATAAAAATCACCTTGTCTTTTGATGATTTGACAGATTATGATATCAAGTT
ATCTGACTTTTTTGGAAATCAAGAAGTCATTGAACAATTTTTCTATGAATTAGTTGATGAACTTGGCTTAGAAAATCGTT
TTGGAAATGTAGGGATGTTAACTTTCCAAATTCAACCCTTCCCACAAGGCGTCCATATGATTGTTCATGAAGAAGCAATG
TTGGGTGAAGGCGGAGAGATTCCAGATGATCCTGAAGAATTTGAAGAATTAATGACTGGTTTTTATAATAAATTAAATGA
AATAGGGGCAGATATGGCGCGCGAGCGAGGAATTACTGATTTTAAACCTGGACTTGGTTTACCAGGGGCTAAAAAAGAAG
AAGCCGAACATGAGCCAGACTTTATATACTACTCTATTCGTTATGATGACATGATGTCTGTCTTGACTGGAATAAAAAAT
GTGAAATTCGCAGATGAAGAGTCAGAATTTTATCGTTATGATGGTAATTTTTATCTTGTTGTTTTAGATAATCAAAAAGC
AAAAGGTAAAATGCATGTTGAAAGCACACGTTCACGGATGATGGAATATGGTGAAGCGACAAAAATGAGTCGAGAATTTT
TGCAGGAGTATGGTGAATGCCTAATCACAACGCGTGCTTTAGACGTTCTTAGAAAAATCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-230)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0M2ZUZ8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Lactococcus lactis subsp. cremoris KW2

100

100

1
  mecA Lactococcus lactis subsp. lactis strain DGCC12653

96.567

100

0.966

Multiple sequence alignment