Detailed information
Bioinformatically predicted
Overview
| Name | clpX | Type | Regulator |
| Locus tag | VOI49_RS04365 | Genome accession | NZ_CP142018 |
| Coordinates | 848646..849875 (+) | Length | 409 a.a. |
| NCBI ID | WP_003050340.1 | Uniprot ID | - |
| Organism | Streptococcus dysgalactiae strain lu24 | ||
| Function | require for competence development (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 821148..897836 | 848646..849875 | within | 0 |
Gene organization within MGE regions
Location: 821148..897836
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VOI49_RS04245 | - | 821148..821747 (+) | 600 | WP_115252808.1 | glycoside hydrolase family 73 protein | - |
| VOI49_RS04250 | - | 821907..822614 (+) | 708 | WP_003050275.1 | glycoside hydrolase family 73 protein | - |
| VOI49_RS04255 | - | 822665..823186 (+) | 522 | WP_003050277.1 | hypothetical protein | - |
| VOI49_RS04260 | - | 823258..823638 (+) | 381 | WP_003050280.1 | DUF1149 family protein | - |
| VOI49_RS04265 | - | 823638..824486 (+) | 849 | WP_003050283.1 | DegV family protein | - |
| VOI49_RS04270 | - | 824606..825814 (+) | 1209 | WP_003050286.1 | CCA tRNA nucleotidyltransferase | - |
| VOI49_RS04275 | - | 825811..827688 (+) | 1878 | WP_003050288.1 | ABC-F family ATP-binding cassette domain-containing protein | - |
| VOI49_RS04280 | - | 827796..829541 (+) | 1746 | WP_324739556.1 | ABC transporter ATP-binding protein | - |
| VOI49_RS04285 | - | 829541..831313 (+) | 1773 | WP_003050294.1 | ABC transporter ATP-binding protein | - |
| VOI49_RS04290 | gdhA | 831570..832919 (+) | 1350 | WP_003050296.1 | NADP-specific glutamate dehydrogenase | - |
| VOI49_RS04295 | - | 833044..833454 (+) | 411 | WP_003050301.1 | peptide deformylase | - |
| VOI49_RS04300 | - | 833642..835666 (-) | 2025 | WP_003050305.1 | surface-anchored 5'-nucleotidase | - |
| VOI49_RS04305 | - | 836128..837849 (+) | 1722 | WP_003050310.1 | ABC transporter ATP-binding protein | - |
| VOI49_RS04310 | - | 837851..839593 (+) | 1743 | WP_226313908.1 | ABC transporter ATP-binding protein | - |
| VOI49_RS04315 | mvk | 839799..840677 (+) | 879 | WP_003050316.1 | mevalonate kinase | - |
| VOI49_RS04320 | mvaD | 840659..841603 (+) | 945 | WP_226313907.1 | diphosphomevalonate decarboxylase | - |
| VOI49_RS04325 | - | 841596..842603 (+) | 1008 | WP_003050321.1 | phosphomevalonate kinase | - |
| VOI49_RS04330 | fni | 842596..843588 (+) | 993 | WP_003050324.1 | type 2 isopentenyl-diphosphate Delta-isomerase | - |
| VOI49_RS04335 | - | 843713..843910 (+) | 198 | Protein_800 | IS3 family transposase | - |
| VOI49_RS04340 | - | 844269..845546 (-) | 1278 | WP_003050330.1 | hydroxymethylglutaryl-CoA reductase, degradative | - |
| VOI49_RS04345 | - | 845527..846708 (-) | 1182 | WP_003050333.1 | hydroxymethylglutaryl-CoA synthase | - |
| VOI49_RS04350 | - | 846923..847762 (+) | 840 | WP_003050334.1 | thymidylate synthase | - |
| VOI49_RS04355 | - | 847843..848340 (+) | 498 | WP_003050336.1 | dihydrofolate reductase | - |
| VOI49_RS04360 | - | 848360..848530 (+) | 171 | WP_003050338.1 | hypothetical protein | - |
| VOI49_RS04365 | clpX | 848646..849875 (+) | 1230 | WP_003050340.1 | ATP-dependent Clp protease ATP-binding subunit ClpX | Regulator |
| VOI49_RS04370 | yihA | 849885..850484 (+) | 600 | WP_115252820.1 | ribosome biogenesis GTP-binding protein YihA/YsxC | - |
| VOI49_RS04375 | - | 850628..851371 (+) | 744 | WP_226313906.1 | hypothetical protein | - |
| VOI49_RS04380 | - | 851428..853536 (-) | 2109 | WP_003050352.1 | AAA family ATPase | - |
| VOI49_RS04385 | - | 853697..854634 (-) | 938 | Protein_810 | IS30 family transposase | - |
| VOI49_RS04390 | rplJ | 854977..855477 (+) | 501 | WP_003050354.1 | 50S ribosomal protein L10 | - |
| VOI49_RS04395 | rplL | 855542..855907 (+) | 366 | WP_003043797.1 | 50S ribosomal protein L7/L12 | - |
| VOI49_RS04400 | - | 856122..856295 (+) | 174 | WP_001169693.1 | hypothetical protein | - |
| VOI49_RS04405 | - | 856292..857110 (+) | 819 | WP_000822793.1 | replication initiator protein A | - |
| VOI49_RS04410 | dcm | 857259..858614 (+) | 1356 | WP_000670054.1 | DNA (cytosine-5-)-methyltransferase | - |
| VOI49_RS04415 | - | 858598..859026 (+) | 429 | WP_001050381.1 | hypothetical protein | - |
| VOI49_RS04420 | - | 859037..859420 (+) | 384 | WP_000895332.1 | hypothetical protein | - |
| VOI49_RS04425 | - | 859429..859662 (+) | 234 | WP_001005706.1 | hypothetical protein | - |
| VOI49_RS04430 | - | 859665..860249 (+) | 585 | WP_000619442.1 | CPBP family intramembrane glutamic endopeptidase | - |
| VOI49_RS04435 | - | 860326..860813 (+) | 488 | Protein_820 | hypothetical protein | - |
| VOI49_RS04440 | - | 860813..862630 (+) | 1818 | WP_000287324.1 | VirD4-like conjugal transfer protein, CD1115 family | - |
| VOI49_RS04445 | - | 862648..862890 (+) | 243 | WP_001072178.1 | hypothetical protein | - |
| VOI49_RS04450 | - | 862909..863763 (+) | 855 | WP_324739557.1 | conjugal transfer protein TrbL | - |
| VOI49_RS04455 | - | 863825..864178 (+) | 354 | WP_001097574.1 | PrgI family protein | - |
| VOI49_RS04460 | - | 864135..866486 (+) | 2352 | WP_000734146.1 | VirB4-like conjugal transfer ATPase, CD1110 family | - |
| VOI49_RS04465 | - | 866488..869289 (+) | 2802 | WP_000656696.1 | phage tail tip lysozyme | - |
| VOI49_RS04470 | - | 869352..870197 (-) | 846 | WP_001030308.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| VOI49_RS04475 | - | 870194..870784 (-) | 591 | WP_000037243.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
| VOI49_RS04480 | - | 870957..875852 (+) | 4896 | WP_044668655.1 | SspB-related isopeptide-forming adhesin | - |
| VOI49_RS04485 | - | 875853..876044 (+) | 192 | WP_001068450.1 | thrombospondin type 3 repeat-containing protein | - |
| VOI49_RS04490 | - | 876028..876579 (+) | 552 | WP_324739558.1 | hypothetical protein | - |
| VOI49_RS04495 | - | 876629..882625 (+) | 5997 | WP_324739559.1 | SNF2-related protein | - |
| VOI49_RS04500 | ltrA | 883185..884843 (+) | 1659 | WP_324739560.1 | group II intron reverse transcriptase/maturase | - |
| VOI49_RS04505 | - | 884938..885786 (+) | 849 | Protein_834 | helicase | - |
| VOI49_RS04510 | - | 885857..886156 (+) | 300 | WP_000079455.1 | DUF5962 family protein | - |
| VOI49_RS04515 | - | 886170..886460 (+) | 291 | WP_000893087.1 | DUF5966 family protein | - |
| VOI49_RS04520 | - | 886556..887194 (+) | 639 | WP_000933073.1 | hypothetical protein | - |
| VOI49_RS04525 | - | 887234..888310 (+) | 1077 | WP_017648738.1 | toprim domain-containing protein | - |
| VOI49_RS04530 | - | 888364..888591 (+) | 228 | WP_017648737.1 | DUF5965 family protein | - |
| VOI49_RS04535 | - | 888588..888977 (+) | 390 | WP_017648736.1 | DUF5945 family protein | - |
| VOI49_RS04540 | - | 888967..889317 (+) | 351 | WP_079262276.1 | hypothetical protein | - |
| VOI49_RS04545 | pezA | 889387..889863 (+) | 477 | WP_000578716.1 | type II toxin-antitoxin system antitoxin PezA | - |
| VOI49_RS04550 | - | 889863..890486 (+) | 624 | Protein_843 | zeta toxin family protein | - |
| VOI49_RS04555 | - | 890576..891440 (+) | 865 | Protein_844 | IS982 family transposase | - |
| VOI49_RS04560 | - | 891504..892682 (+) | 1179 | WP_001121910.1 | DNA cytosine methyltransferase | - |
| VOI49_RS04565 | - | 892685..894721 (+) | 2037 | WP_000456196.1 | ATP-binding protein | - |
| VOI49_RS04570 | - | 895253..895612 (+) | 360 | WP_000529541.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| VOI49_RS04575 | - | 895622..895987 (+) | 366 | WP_000263034.1 | MobC family plasmid mobilization relaxosome protein | - |
| VOI49_RS04580 | - | 895974..897836 (+) | 1863 | WP_000261816.1 | SAG1250 family conjugative relaxase | - |
Sequence
Protein
Download Length: 409 a.a. Molecular weight: 45072.60 Da Isoelectric Point: 4.5866
>NTDB_id=921020 VOI49_RS04365 WP_003050340.1 848646..849875(+) (clpX) [Streptococcus dysgalactiae strain lu24]
MAGNRTNDIKVYCSFCGKSQDEVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLEVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDEDVELQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEDIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIQI
LTEPRNALVKQYQALLSYDGVELAFDKEALEAIANKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVIKVRITKAAVEG
KSKPVLETA
MAGNRTNDIKVYCSFCGKSQDEVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLEVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDEDVELQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEDIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIQI
LTEPRNALVKQYQALLSYDGVELAFDKEALEAIANKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVIKVRITKAAVEG
KSKPVLETA
Nucleotide
Download Length: 1230 bp
>NTDB_id=921020 VOI49_RS04365 WP_003050340.1 848646..849875(+) (clpX) [Streptococcus dysgalactiae strain lu24]
ATGGCAGGAAATCGTACAAACGATATTAAAGTATATTGCTCATTTTGTGGCAAGAGCCAAGACGAAGTCAAAAAAATTAT
TGCAGGGAATAATGTTTTTATCTGTAATGAATGTGTGGCTTTGTCACAAGAAATTATTAAAGAAGAGTTGGCAGAAGAAG
TATTAGCTGATCTAACAGAAGTTCCAAAACCCAAAGAGCTCCTTGAGGTTTTAAACCAGTATGTTGTTGGCCAAGATCGT
GCCAAACGTGCTTTATCAGTAGCTGTTTACAATCATTACAAACGCGTATCATTCACGGAAAGTCGTGATGATGAAGATGT
GGAATTGCAAAAATCAAACATTTTAATGATTGGTCCAACAGGTTCAGGAAAGACTTTTCTGGCTCAAACCTTAGCTAAGA
GCTTAAATGTTCCCTTCGCGATTGCTGATGCAACCTCACTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
CTTCTCAAGCTTATCCAAGCAGCTGATTATAATGTGGAACGAGCAGAGCGTGGTATCATCTATGTCGATGAAATTGATAA
GATTGCTAAAAAAGGCGAAAATGTGTCCATCACACGTGATGTTTCTGGTGAGGGAGTTCAGCAGGCCTTACTAAAAATTA
TTGAAGGAACGGTTGCTAGTGTTCCTCCTCAAGGCGGTCGTAAGCATCCAAATCAGGAAATGATTCAAATTGATACCAAG
AATATCTTGTTTATTGTTGGGGGAGCCTTTGACGGCATTGAAGATATTGTCAAACAACGTTTAGGAGAAAAAGTCATTGG
TTTTGGTCAAAACAGCCGAAAAATCGACGACAATGCTTCTTATATGCAAGAGATTATTTCAGAAGATATCCAAAAATTTG
GTCTTATACCAGAGTTTATTGGACGCTTGCCAGTCGTAGCTGCTCTTGAACAACTAAACACATCAGATTTGATTCAGATT
TTGACAGAACCAAGAAATGCCCTAGTCAAGCAATATCAAGCTCTTCTTTCTTACGATGGCGTCGAATTGGCATTTGATAA
GGAAGCCTTAGAAGCCATTGCAAATAAAGCCATTGAGCGTAAGACAGGCGCGCGTGGTCTTCGTTCTATTATCGAAGAAA
CAATGTTAGACATTATGTTTGAAATTCCAAGCCAAGAAGATGTCATAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCGTAA
ATGGCAGGAAATCGTACAAACGATATTAAAGTATATTGCTCATTTTGTGGCAAGAGCCAAGACGAAGTCAAAAAAATTAT
TGCAGGGAATAATGTTTTTATCTGTAATGAATGTGTGGCTTTGTCACAAGAAATTATTAAAGAAGAGTTGGCAGAAGAAG
TATTAGCTGATCTAACAGAAGTTCCAAAACCCAAAGAGCTCCTTGAGGTTTTAAACCAGTATGTTGTTGGCCAAGATCGT
GCCAAACGTGCTTTATCAGTAGCTGTTTACAATCATTACAAACGCGTATCATTCACGGAAAGTCGTGATGATGAAGATGT
GGAATTGCAAAAATCAAACATTTTAATGATTGGTCCAACAGGTTCAGGAAAGACTTTTCTGGCTCAAACCTTAGCTAAGA
GCTTAAATGTTCCCTTCGCGATTGCTGATGCAACCTCACTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
CTTCTCAAGCTTATCCAAGCAGCTGATTATAATGTGGAACGAGCAGAGCGTGGTATCATCTATGTCGATGAAATTGATAA
GATTGCTAAAAAAGGCGAAAATGTGTCCATCACACGTGATGTTTCTGGTGAGGGAGTTCAGCAGGCCTTACTAAAAATTA
TTGAAGGAACGGTTGCTAGTGTTCCTCCTCAAGGCGGTCGTAAGCATCCAAATCAGGAAATGATTCAAATTGATACCAAG
AATATCTTGTTTATTGTTGGGGGAGCCTTTGACGGCATTGAAGATATTGTCAAACAACGTTTAGGAGAAAAAGTCATTGG
TTTTGGTCAAAACAGCCGAAAAATCGACGACAATGCTTCTTATATGCAAGAGATTATTTCAGAAGATATCCAAAAATTTG
GTCTTATACCAGAGTTTATTGGACGCTTGCCAGTCGTAGCTGCTCTTGAACAACTAAACACATCAGATTTGATTCAGATT
TTGACAGAACCAAGAAATGCCCTAGTCAAGCAATATCAAGCTCTTCTTTCTTACGATGGCGTCGAATTGGCATTTGATAA
GGAAGCCTTAGAAGCCATTGCAAATAAAGCCATTGAGCGTAAGACAGGCGCGCGTGGTCTTCGTTCTATTATCGAAGAAA
CAATGTTAGACATTATGTTTGAAATTCCAAGCCAAGAAGATGTCATAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCGTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| clpX | Streptococcus mutans UA159 |
89.242 |
100 |
0.892 |
| clpX | Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 |
58.603 |
98.044 |
0.575 |