Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   L6419_RS02545 Genome accession   NZ_AP025332
Coordinates   497617..499839 (-) Length   740 a.a.
NCBI ID   WP_237375620.1    Uniprot ID   -
Organism   Streptococcus ruminantium strain GUT-184     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 492617..504839
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L6419_RS02515 (GUT184_04490) - 493821..494027 (-) 207 WP_024533122.1 hypothetical protein -
  L6419_RS02520 (GUT184_04500) tnpB 494081..494431 (-) 351 WP_155964103.1 IS66 family insertion sequence element accessory protein TnpB -
  L6419_RS02525 (GUT184_04510) - 494412..494600 (-) 189 WP_155964102.1 hypothetical protein -
  L6419_RS02530 (GUT184_04520) - 494801..496372 (-) 1572 WP_237375619.1 YSIRK-type signal peptide-containing protein -
  L6419_RS02535 (GUT184_04530) - 496563..496871 (-) 309 WP_024532451.1 DUF1827 family protein -
  L6419_RS02540 (GUT184_04540) - 496962..497423 (-) 462 WP_024532452.1 NUDIX hydrolase -
  L6419_RS02545 (GUT184_04550) clpE 497617..499839 (-) 2223 WP_237375620.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  L6419_RS02550 (GUT184_04560) - 500068..500298 (+) 231 WP_024532454.1 DUF1797 family protein -
  L6419_RS02555 (GUT184_04570) - 500424..501113 (+) 690 WP_155963306.1 amino acid ABC transporter permease -
  L6419_RS02560 (GUT184_04580) - 501106..501840 (+) 735 WP_155964099.1 amino acid ABC transporter ATP-binding protein -
  L6419_RS02565 (GUT184_04590) - 502029..502877 (+) 849 WP_156008032.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  L6419_RS02570 (GUT184_04600) - 503362..504270 (-) 909 WP_155964098.1 neutral zinc metallopeptidase -

Sequence

Protein


Download         Length: 740 a.a.        Molecular weight: 82453.77 Da        Isoelectric Point: 5.3516

>NTDB_id=91179 L6419_RS02545 WP_237375620.1 497617..499839(-) (clpE) [Streptococcus ruminantium strain GUT-184]
MLCKNCNINDATIHLYTNLNGKQQQVDLCHNCYQIMKTDPNNAILRGLGDMVNPNNMDPFSEFFNHLGGYPGNTPAGKKR
EQTPPTQSGGSHNGRGGQTPPPQQPNGLLEEFGINVTDIARRGDIDPVIGRDQEITRVIEILNRRTKNNPVLIGEPGVGK
TAVVEGLAQKIVDGDVPQKLRGKEVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRREIILFIDEIHEIVGAGSAGDGN
MDAGNILKPALARGEMQLVGATTLNEYRIIEKDAALERRMQPVKVEEPSVEETITILKGIQSKYQDYHHVKYSDTAIEAA
AVLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPREIDQRLLDAENRKAQATRDEDYEKAAYFRDQIAKYKEMQKAT
ISEEDTPLITEKEIEAIVEQKTNIPVGDLKEKEQSQLINLANDLKAHVIGQDEAVDKIAKAIRRNRVGLGAPNRPIGSFL
FVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHAISKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILLDEIEKA
HPDVLHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGASMEGRTQSVLGQLSNFFTPEFMNRFDGII
EFQPLSKENLLEIVSLMLEDVNQRLSHNGINLHITDKVKEKLVDLGYDPKMGARPLRRTIQDQIEDAITDFYLENPSEKN
LRAVMTSKGTIQIKAQTKTK

Nucleotide


Download         Length: 2223 bp        

>NTDB_id=91179 L6419_RS02545 WP_237375620.1 497617..499839(-) (clpE) [Streptococcus ruminantium strain GUT-184]
ATGCTCTGCAAAAATTGTAATATCAACGACGCAACGATCCATCTCTATACCAATCTAAACGGTAAACAGCAACAGGTTGA
CCTCTGTCACAATTGTTATCAAATCATGAAAACAGATCCAAATAATGCTATCCTACGCGGCTTAGGTGACATGGTAAATC
CTAATAATATGGATCCATTTAGCGAGTTCTTCAATCATCTGGGAGGCTATCCAGGTAATACACCTGCTGGCAAAAAACGT
GAACAGACCCCTCCAACTCAGTCTGGCGGAAGTCACAATGGTCGTGGTGGGCAGACGCCTCCTCCACAACAGCCCAATGG
TCTCTTGGAAGAATTTGGAATCAATGTGACCGATATTGCTCGCCGAGGCGACATTGACCCAGTAATTGGTCGCGATCAAG
AAATTACACGGGTCATTGAGATTCTCAACCGCAGGACCAAAAACAATCCCGTCCTCATCGGAGAGCCAGGTGTGGGTAAG
ACTGCGGTTGTTGAAGGTCTAGCTCAAAAAATCGTTGATGGTGATGTTCCACAAAAACTGCGAGGAAAAGAGGTTATCCG
ACTCGATGTGGTAAGTTTGGTCCAAGGGACAGGCATTCGTGGGCAATTTGAAGAACGGATGCAAAAACTGATGGAAGAAA
TCCGCAACCGCCGGGAAATCATCCTCTTTATTGATGAGATCCATGAAATCGTCGGAGCTGGTTCTGCCGGTGATGGTAAT
ATGGATGCAGGAAACATTCTCAAGCCAGCTTTGGCTCGTGGGGAAATGCAATTAGTGGGGGCAACCACCCTCAACGAATA
CCGCATCATTGAGAAGGATGCTGCTCTTGAACGACGCATGCAACCAGTAAAAGTGGAAGAACCTAGCGTTGAAGAAACAA
TCACCATTCTCAAGGGTATTCAAAGCAAATACCAAGATTATCACCACGTTAAGTATTCAGATACGGCCATTGAAGCTGCA
GCTGTTCTTTCCAATCGCTATATTCAAGACCGCTTTCTACCAGACAAGGCCATTGACCTACTGGACGAAGCCGGCTCCAA
AATGAACCTGACCCTCAACTTTGTTGACCCAAGGGAAATTGATCAGCGCTTGCTTGACGCTGAGAATCGTAAGGCTCAAG
CCACACGTGACGAGGATTATGAAAAAGCAGCTTATTTCCGCGATCAGATTGCAAAGTATAAGGAAATGCAAAAGGCTACC
ATCAGCGAAGAGGATACACCGCTCATTACCGAAAAAGAAATCGAAGCCATTGTCGAGCAAAAAACCAATATTCCCGTCGG
TGATTTGAAAGAAAAAGAACAATCACAGCTTATCAATCTAGCAAACGATCTAAAAGCGCATGTGATCGGTCAAGATGAAG
CCGTTGATAAGATTGCAAAGGCTATCCGTCGCAATCGTGTCGGTCTGGGGGCGCCAAATCGCCCAATCGGCTCCTTCCTC
TTTGTTGGTCCGACTGGTGTCGGTAAAACAGAGTTGTCCAAACAACTCGCCATTGAACTCTTTGGATCGGCTGATAGTAT
GATTCGCTTTGATATGTCCGAATACATGGAAAAACACGCTATTTCCAAGTTAGTCGGAGCACCTCCAGGCTATGTCGGTT
ATGAAGAAGCAGGACAACTAACAGAAAAAGTTCGCCGCAATCCTTATTCACTCATCCTCTTAGATGAGATAGAAAAGGCT
CATCCAGATGTCTTGCACATGTTCCTCCAAGTCTTGGATGATGGACGCTTGACAGACGGACAAGGACGGACAGTCAGCTT
TAAAGACACCATCATCATCATGACATCCAATGCGGGGACGGGCAAGGTTGAAGCCAGCGTTGGTTTTGGTGCCAGCATGG
AAGGACGAACACAATCTGTCCTCGGTCAACTCAGTAACTTCTTTACCCCAGAGTTCATGAATCGTTTTGATGGGATTATC
GAATTCCAACCGCTCAGCAAGGAAAATCTACTAGAAATCGTCAGCCTCATGTTGGAGGATGTCAACCAGCGGCTTTCTCA
CAACGGTATCAACCTACATATCACAGATAAGGTCAAGGAAAAATTGGTTGACTTGGGCTACGACCCAAAAATGGGAGCTC
GTCCGCTTCGCCGAACTATCCAAGATCAAATTGAGGACGCTATTACTGATTTTTATCTGGAAAATCCAAGTGAAAAGAAC
CTGCGAGCAGTCATGACGAGCAAGGGAACTATCCAAATCAAGGCTCAAACAAAAACCAAATAA

Domains

Predicted by InterproScan.

ATPase family associated with various cellular activities (AAA) (AAA)

(151-270)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(645-720)

AAA lid domain (AAA_lid_9)

(289-387)

AAA domain (Cdc48 subfamily) (AAA_2)

(474-637)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

82.024

100

0.832
  clpE Streptococcus pneumoniae D39

82.024

100

0.832
  clpE Streptococcus pneumoniae R6

82.024

100

0.832
  clpE Streptococcus pneumoniae TIGR4

82.024

100

0.832
  clpE Streptococcus mutans UA159

81.417

100

0.823
  clpC Lactococcus lactis subsp. cremoris KW2

77.178

97.703

0.754
  clpC Bacillus subtilis subsp. subtilis str. 168

51.042

90.811

0.464
  clpC Streptococcus thermophilus LMD-9

47.434

86.892

0.412
  clpC Streptococcus thermophilus LMG 18311

47.123

86.892

0.409
  clpC Streptococcus pneumoniae TIGR4

47.84

84.459

0.404
  clpC Streptococcus pneumoniae Rx1

47.84

84.459

0.404
  clpC Streptococcus pneumoniae D39

47.84

84.459

0.404
  clpC Streptococcus mutans UA159

47.833

84.189

0.403
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

46.338

84.865

0.393

Multiple sequence alignment