Detailed information NTG0911405

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: U0447_RS03980
• Genome accession: NZ_CP139861
• Coordinates: 756040..757077 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain 16H2017-2
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 751040..762077

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U0447_RS03955	-	751779..753110 (-)	1332	WP_000390039.1	hemolysin family protein	-
U0447_RS03960	endA	753401..754225 (-)	825	WP_050232570.1	DNA-entry nuclease EndA	Machinery gene
U0447_RS03965	-	754264..754452 (-)	189	WP_001813390.1	DNA-directed RNA polymerase subunit beta	-
U0447_RS03970	murA	754445..755728 (-)	1284	WP_000358035.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
U0447_RS03975	-	755752..755982 (-)	231	WP_001809307.1	DUF1146 family protein	-
U0447_RS03980	sepM	756040..757077 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
U0447_RS03985	coaD	757061..757549 (-)	489	WP_001280736.1	pantetheine-phosphate adenylyltransferase	-
U0447_RS03990	rsmD	757539..758078 (-)	540	WP_044788620.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
U0447_RS03995	asnA	758143..759135 (-)	993	WP_044791888.1	aspartate--ammonia ligase	-
U0447_RS04000	-	759246..759929 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
U0447_RS04005	-	759985..760725 (-)	741	WP_044791890.1	RNA methyltransferase	-
U0447_RS04010	-	760759..761037 (+)	279	WP_001174613.1	acylphosphatase	-
U0447_RS04015	yidC	761115..762041 (+)	927	WP_000835941.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=911405 U0447_RS03980 WP_000727277.1 756040..757077(-) (sepM) [Streptococcus pneumoniae strain 16H2017-2]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=911405 U0447_RS03980 WP_000727277.1 756040..757077(-) (sepM) [Streptococcus pneumoniae strain 16H2017-2]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACGGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGACTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGAAAAAATGGGATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591