Detailed information NTG0911327

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: U0448_RS03870
• Genome accession: NZ_CP139860
• Coordinates: 768219..769256 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain 21011
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 763219..774256

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U0448_RS03845	-	763958..765289 (-)	1332	WP_000390039.1	hemolysin family protein	-
U0448_RS03850	endA	765580..766404 (-)	825	WP_001036791.1	DNA-entry nuclease EndA	Machinery gene
U0448_RS03855	-	766443..766631 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
U0448_RS03860	murA	766624..767907 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
U0448_RS03865	-	767931..768161 (-)	231	WP_000250393.1	DUF1146 family protein	-
U0448_RS03870	sepM	768219..769256 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
U0448_RS03875	coaD	769240..769728 (-)	489	WP_050255559.1	pantetheine-phosphate adenylyltransferase	-
U0448_RS03880	rsmD	769718..770257 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
U0448_RS03885	asnA	770322..771314 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
U0448_RS03890	-	771426..772109 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
U0448_RS03895	-	772165..772905 (-)	741	WP_000152680.1	RNA methyltransferase	-
U0448_RS03900	-	772939..773217 (+)	279	WP_001174613.1	acylphosphatase	-
U0448_RS03905	yidC	773295..774221 (+)	927	WP_000835941.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=911327 U0448_RS03870 WP_000727277.1 768219..769256(-) (sepM) [Streptococcus pneumoniae strain 21011]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=911327 U0448_RS03870 WP_000727277.1 768219..769256(-) (sepM) [Streptococcus pneumoniae strain 21011]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCTACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCACAAAATATGGCCAAGTATCAAGGTCTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGGGTTTATGTCT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACGGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGACTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGAAAAAATGGGATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591