Detailed information    

insolico Bioinformatically predicted

Overview

Name   endA   Type   Machinery gene
Locus tag   U0448_RS03850 Genome accession   NZ_CP139860
Coordinates   765580..766404 (-) Length   274 a.a.
NCBI ID   WP_001036791.1    Uniprot ID   A0A0B7L7Z9
Organism   Streptococcus pneumoniae strain 21011     
Function   cleavage of dsDNA into ssDNA (predicted from homology)   
DNA processing

Genomic Context

Location: 760580..771404
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0448_RS03845 - 763958..765289 (-) 1332 WP_000390039.1 hemolysin family protein -
  U0448_RS03850 endA 765580..766404 (-) 825 WP_001036791.1 DNA-entry nuclease EndA Machinery gene
  U0448_RS03855 - 766443..766631 (-) 189 WP_001036519.1 DNA-directed RNA polymerase subunit beta -
  U0448_RS03860 murA 766624..767907 (-) 1284 WP_000358028.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
  U0448_RS03865 - 767931..768161 (-) 231 WP_000250393.1 DUF1146 family protein -
  U0448_RS03870 sepM 768219..769256 (-) 1038 WP_000727277.1 SepM family pheromone-processing serine protease Regulator
  U0448_RS03875 coaD 769240..769728 (-) 489 WP_050255559.1 pantetheine-phosphate adenylyltransferase -
  U0448_RS03880 rsmD 769718..770257 (-) 540 WP_000706963.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  U0448_RS03885 asnA 770322..771314 (-) 993 WP_000747993.1 aspartate--ammonia ligase -

Sequence

Protein


Download         Length: 274 a.a.        Molecular weight: 29939.65 Da        Isoelectric Point: 10.1700

>NTDB_id=911326 U0448_RS03850 WP_001036791.1 765580..766404(-) (endA) [Streptococcus pneumoniae strain 21011]
MNKKTRQTLIGLLVLLLLSTGSYYIKQMQSTANSPKTKLSQKKQASEAPSQALAESVLTDAVKSQIKGSLEWNGSGAFIV
NGNKTNLDAKVSSKPYADNKTKTVGKETVPTVANALLSKATRQYKNRKETGNGSTSWTPPGWHQVKNLKGSYTHAVDRGH
LLGYALIGGLDGFDASTSNPKNIAVQTAWANQAQAEYSTGQNYYESKVRKALDQNKRVRYRVTLYYASNEDLVPSASQIE
AKSSDGELEFNVLVPNVQKGLQLDYRTGEVTVTQ

Nucleotide


Download         Length: 825 bp        

>NTDB_id=911326 U0448_RS03850 WP_001036791.1 765580..766404(-) (endA) [Streptococcus pneumoniae strain 21011]
ATGAACAAAAAAACAAGACAGACACTAATCGGACTGCTAGTGTTATTGCTTTTGTCTACAGGGAGCTATTATATCAAGCA
GATGCAGTCGACAGCTAATAGTCCTAAAACCAAGCTTAGTCAGAAAAAACAAGCGTCTGAAGCTCCTAGTCAAGCATTGG
CAGAGAGTGTCTTAACAGACGCAGTCAAGAGTCAAATAAAGGGGAGTCTGGAGTGGAATGGCTCAGGTGCTTTTATCGTC
AATGGTAATAAAACAAATCTAGATGCCAAGGTTTCAAGTAAGCCCTACGCTGACAATAAAACAAAGACAGTGGGCAAGGA
AACTGTTCCAACCGTAGCTAATGCCCTCTTGTCTAAGGCCACTCGTCAGTACAAGAATCGTAAAGAAACTGGGAATGGTT
CAACTTCTTGGACTCCTCCAGGTTGGCATCAGGTCAAGAATCTAAAGGGCTCTTATACCCATGCAGTCGATAGAGGTCAT
TTGTTAGGCTATGCCTTAATCGGTGGTTTGGATGGTTTTGATGCCTCAACAAGCAATCCTAAAAACATTGCTGTTCAGAC
AGCCTGGGCAAATCAGGCACAAGCCGAGTATTCGACTGGTCAAAACTACTATGAAAGCAAGGTGCGTAAAGCCTTGGACC
AAAACAAGCGTGTCCGTTACCGTGTAACCCTTTACTACGCTTCAAACGAGGATTTAGTTCCCTCAGCTTCACAGATTGAA
GCCAAGTCTTCGGATGGAGAATTGGAATTCAATGTTCTAGTTCCCAATGTTCAAAAGGGACTTCAACTGGATTACCGAAC
TGGAGAAGTAACTGTAACTCAGTAA

Domains

Predicted by InterproScan.

DNA/RNA non-specific endonuclease (Endonuclease_NS)

(75-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7L7Z9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  endA Streptococcus pneumoniae Rx1

98.54

100

0.985
  endA Streptococcus pneumoniae D39

98.54

100

0.985
  endA Streptococcus pneumoniae R6

98.54

100

0.985
  endA Streptococcus pneumoniae TIGR4

98.54

100

0.985