Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   ABD408_RS06825 Genome accession   NZ_CP155735
Coordinates   1375221..1375862 (-) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain 4958/15     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1370221..1380862
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABD408_RS06800 (ABD408_06770) comFA/cflA 1370307..1371632 (-) 1326 WP_023611937.1 DEAD/DEAH box helicase Machinery gene
  ABD408_RS06805 (ABD408_06775) - 1371688..1372320 (+) 633 WP_032465539.1 YigZ family protein -
  ABD408_RS06810 (ABD408_06780) cysK 1372448..1373389 (+) 942 WP_011888673.1 cysteine synthase A -
  ABD408_RS06815 (ABD408_06785) - 1373407..1373784 (-) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  ABD408_RS06820 (ABD408_06790) - 1373784..1375184 (-) 1401 WP_023611922.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  ABD408_RS06825 (ABD408_06795) vraR 1375221..1375862 (-) 642 WP_002983671.1 response regulator transcription factor Regulator
  ABD408_RS06830 (ABD408_06800) - 1375855..1376859 (-) 1005 WP_002991890.1 sensor histidine kinase -
  ABD408_RS06835 (ABD408_06805) liaF 1376856..1377548 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  ABD408_RS06840 (ABD408_06810) pknB 1377671..1379569 (-) 1899 WP_012560855.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  ABD408_RS06845 (ABD408_06815) - 1379566..1380306 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=898150 ABD408_RS06825 WP_002983671.1 1375221..1375862(-) (vraR) [Streptococcus pyogenes strain 4958/15]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=898150 ABD408_RS06825 WP_002983671.1 1375221..1375862(-) (vraR) [Streptococcus pyogenes strain 4958/15]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385