Detailed information NTG0896250

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: R4705_RS04000
• Genome accession: NZ_CP137115
• Coordinates: 752204..753241 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain 20614-6
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 747204..758241

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4705_RS03975	-	747943..749274 (-)	1332	WP_000390039.1	hemolysin family protein	-
R4705_RS03980	endA	749565..750389 (-)	825	WP_001036787.1	DNA-entry nuclease EndA	Machinery gene
R4705_RS03985	-	750428..750616 (-)	189	WP_001813390.1	DNA-directed RNA polymerase subunit beta	-
R4705_RS03990	murA	750609..751892 (-)	1284	WP_279513424.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
R4705_RS03995	-	751916..752146 (-)	231	WP_000250384.1	DUF1146 family protein	-
R4705_RS04000	sepM	752204..753241 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
R4705_RS04005	coaD	753225..753713 (-)	489	WP_001280769.1	pantetheine-phosphate adenylyltransferase	-
R4705_RS04010	rsmD	753703..754242 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
R4705_RS04015	asnA	754307..755299 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
R4705_RS04020	-	755411..756094 (-)	684	WP_001016910.1	Bax inhibitor-1/YccA family protein	-
R4705_RS04025	-	756150..756890 (-)	741	WP_000152678.1	RNA methyltransferase	-
R4705_RS04030	-	756924..757202 (+)	279	WP_001174613.1	acylphosphatase	-
R4705_RS04035	yidC	757280..758206 (+)	927	WP_000835941.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=896250 R4705_RS04000 WP_000727277.1 752204..753241(-) (sepM) [Streptococcus pneumoniae strain 20614-6]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=896250 R4705_RS04000 WP_000727277.1 752204..753241(-) (sepM) [Streptococcus pneumoniae strain 20614-6]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACCTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCACAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAAATCATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591