Detailed information NTG0896020

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: R4700_RS04035
• Genome accession: NZ_CP137112
• Coordinates: 784792..785829 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain 02H2025
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 779792..790829

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4700_RS04010	-	780531..781862 (-)	1332	WP_000390039.1	hemolysin family protein	-
R4700_RS04015	endA	782153..782977 (-)	825	WP_001036791.1	DNA-entry nuclease EndA	Machinery gene
R4700_RS04020	-	783016..783204 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
R4700_RS04025	murA	783197..784480 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
R4700_RS04030	-	784504..784734 (-)	231	WP_000250393.1	DUF1146 family protein	-
R4700_RS04035	sepM	784792..785829 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
R4700_RS04040	coaD	785813..786301 (-)	489	WP_001280740.1	pantetheine-phosphate adenylyltransferase	-
R4700_RS04045	rsmD	786291..786830 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
R4700_RS04050	asnA	786895..787887 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
R4700_RS04055	-	787999..788682 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
R4700_RS04060	-	788738..789478 (-)	741	WP_000152678.1	RNA methyltransferase	-
R4700_RS04065	-	789512..789790 (+)	279	WP_277770907.1	acylphosphatase	-
R4700_RS04070	yidC	789868..790794 (+)	927	WP_000835941.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=896020 R4700_RS04035 WP_000727277.1 784792..785829(-) (sepM) [Streptococcus pneumoniae strain 02H2025]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=896020 R4700_RS04035 WP_000727277.1 784792..785829(-) (sepM) [Streptococcus pneumoniae strain 02H2025]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACGGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGACTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGAAAAAATGGAATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591