Detailed information NTG0895883

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: R4712_RS06740
• Genome accession: NZ_CP137110
• Coordinates: 1318946..1319983 (+)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain 16H2041
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1313946..1324983

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4712_RS06705	yidC	1313982..1314908 (-)	927	WP_000835941.1	membrane protein insertase YidC	-
R4712_RS06710	-	1314986..1315264 (-)	279	WP_001174613.1	acylphosphatase	-
R4712_RS06715	-	1315298..1316038 (+)	741	WP_044791890.1	RNA methyltransferase	-
R4712_RS06720	-	1316094..1316777 (+)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
R4712_RS06725	asnA	1316888..1317880 (+)	993	WP_044791888.1	aspartate--ammonia ligase	-
R4712_RS06730	rsmD	1317945..1318484 (+)	540	WP_044788620.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
R4712_RS06735	coaD	1318474..1318962 (+)	489	WP_001280736.1	pantetheine-phosphate adenylyltransferase	-
R4712_RS06740	sepM	1318946..1319983 (+)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
R4712_RS06745	-	1320041..1320271 (+)	231	WP_001809307.1	DUF1146 family protein	-
R4712_RS06750	murA	1320295..1321578 (+)	1284	WP_000358027.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
R4712_RS06755	-	1321571..1321759 (+)	189	WP_001812859.1	DNA-directed RNA polymerase subunit beta	-
R4712_RS06760	endA	1321798..1322622 (+)	825	WP_317818415.1	DNA-entry nuclease EndA	Machinery gene
R4712_RS06765	-	1322913..1324244 (+)	1332	WP_000390042.1	hemolysin family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=895883 R4712_RS06740 WP_000727277.1 1318946..1319983(+) (sepM) [Streptococcus pneumoniae strain 16H2041]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=895883 R4712_RS06740 WP_000727277.1 1318946..1319983(+) (sepM) [Streptococcus pneumoniae strain 16H2041]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTGGTGCCTTTGCC
CTACTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACGGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGACTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGAAAAAATGGGATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591