Detailed information NTG0895832

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: R4704_RS10240
• Genome accession: NZ_CP137109
• Coordinates: 1971068..1973308 (+)
• Length: 746 a.a.
• NCBI ID: WP_033705318.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 11012
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1966068..1978308

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4704_RS10210	-	1966219..1967187 (+)	969	WP_000658183.1	PhoH family protein	-
R4704_RS10215	-	1967380..1967880 (+)	501	WP_000566988.1	GNAT family N-acetyltransferase	-
R4704_RS10220	-	1967883..1968208 (+)	326	Protein_1975	TfoX/Sxy family protein	-
R4704_RS10225	ald	1968509..1969620 (-)	1112	Protein_1976	alanine dehydrogenase	-
R4704_RS10230	-	1969797..1970366 (+)	570	WP_001864145.1	GNAT family N-acetyltransferase	-
R4704_RS10235	comEA/celA/cilE	1970434..1971084 (+)	651	WP_001864147.1	helix-hairpin-helix domain-containing protein	Machinery gene
R4704_RS10240	comEC/celB	1971068..1973308 (+)	2241	WP_033705318.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
R4704_RS10245	-	1973450..1973674 (+)	225	WP_015898758.1	hypothetical protein	-
R4704_RS10250	-	1973706..1974293 (+)	588	WP_000933540.1	ATP-binding cassette domain-containing protein	-
R4704_RS10255	-	1974297..1975475 (+)	1179	WP_033705319.1	membrane protein	-
R4704_RS10260	infC	1975786..1976316 (+)	531	WP_000848180.1	translation initiation factor IF-3	-
R4704_RS10265	rpmI	1976349..1976549 (+)	201	WP_001125943.1	50S ribosomal protein L35	-
R4704_RS10270	rplT	1976601..1976960 (+)	360	WP_000124836.1	50S ribosomal protein L20	-
R4704_RS10275	-	1977018..1977398 (+)	381	WP_033705321.1	VOC family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84448.87 Da
• Isoelectric Point: 9.3992

>NTDB_id=895832 R4704_RS10240 WP_033705318.1 1971068..1973308(+) (comEC/celB) [Streptococcus pneumoniae strain 11012]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKTIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVTSESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLVFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVASSPLVFGQPNEWLLILLLISLALVYDLRKNIKGLTVLSLLITGLFFLTK
YPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKTTTSNAQRSLIPYLKSRGVAKIDQLILTNTDK
EHVGDLLEVTKAFHVGEILVSKGSLKQKQFVAELQVTQTKVRSMTVGEYLPIFGSQLEVLSPREIGYGGHEDSLVLYGKL
LNNHFLFIGNLEEKGEKDLLKYYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=895832 R4704_RS10240 WP_033705318.1 1971068..1973308(+) (comEC/celB) [Streptococcus pneumoniae strain 11012]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTATTACTTTGGCTTTATTACGCTATTTT
CTCAGCATCTTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCGTGGAAATCTGCTG
GTAAAGTTCTAATAATTTGCGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAACAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCGAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGTATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGCTTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTACTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTTTTTGACTTGGTCTTCTTACCGCTCTTGTCTATC
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTGGAGGGCATTATTCGCTTGGT
GTCACAGGTGGCAAGTAGTCCTCTAGTCTTTGGACAACCCAATGAATGGCTTTTAATCCTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAGGATTAACAGTATTGAGTTTATTGATTACAGGTCTCTTTTTCCTTACCAAG
TATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGACGACGACCAGCAATG
CACAGAGAAGCTTGATACCCTATCTTAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTGATTTTGACAAATACGGACAAG
GAACATGTCGGAGATTTGTTAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTTTAGTATCAAAAGGCAGTTTGAAGCA
GAAGCAATTTGTGGCAGAACTACAGGTGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGTACTTGCCCATTTTCG
GAAGTCAGTTAGAAGTCCTATCTCCAAGGGAAATTGGATATGGAGGTCATGAAGATTCCCTGGTTCTTTATGGGAAACTC
TTGAATAATCACTTTCTCTTCATAGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGTACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTACCGAACTGACCAGCAAGGAGCTATACGCTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

• Domain of unknown function (DUF4131) (DUF4131) (30-176)

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-630)

• Competence protein (Competence) (216-458)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus pneumoniae TIGR4	96.649	100	0.966
comEC/celB	Streptococcus pneumoniae Rx1	95.174	100	0.952
comEC/celB	Streptococcus pneumoniae D39	95.174	100	0.952
comEC/celB	Streptococcus pneumoniae R6	95.174	100	0.952
comEC/celB	Streptococcus mitis NCTC 12261	92.081	99.866	0.92
comEC/celB	Streptococcus mitis SK321	91.957	100	0.92
comEC	Lactococcus lactis subsp. cremoris KW2	44.399	99.33	0.441