Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   R4704_RS10235 Genome accession   NZ_CP137109
Coordinates   1970434..1971084 (+) Length   216 a.a.
NCBI ID   WP_001864147.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 11012     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1965434..1976084
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4704_RS10205 - 1965918..1966133 (+) 216 WP_001232082.1 YozE family protein -
  R4704_RS10210 - 1966219..1967187 (+) 969 WP_000658183.1 PhoH family protein -
  R4704_RS10215 - 1967380..1967880 (+) 501 WP_000566988.1 GNAT family N-acetyltransferase -
  R4704_RS10220 - 1967883..1968208 (+) 326 Protein_1975 TfoX/Sxy family protein -
  R4704_RS10225 ald 1968509..1969620 (-) 1112 Protein_1976 alanine dehydrogenase -
  R4704_RS10230 - 1969797..1970366 (+) 570 WP_001864145.1 GNAT family N-acetyltransferase -
  R4704_RS10235 comEA/celA/cilE 1970434..1971084 (+) 651 WP_001864147.1 helix-hairpin-helix domain-containing protein Machinery gene
  R4704_RS10240 comEC/celB 1971068..1973308 (+) 2241 WP_033705318.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  R4704_RS10245 - 1973450..1973674 (+) 225 WP_015898758.1 hypothetical protein -
  R4704_RS10250 - 1973706..1974293 (+) 588 WP_000933540.1 ATP-binding cassette domain-containing protein -
  R4704_RS10255 - 1974297..1975475 (+) 1179 WP_033705319.1 membrane protein -

Sequence

Protein


Download         Length: 216 a.a.        Molecular weight: 23205.54 Da        Isoelectric Point: 5.5171

>NTDB_id=895831 R4704_RS10235 WP_001864147.1 1970434..1971084(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain 11012]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQVEVAAVSKDLVSEKEVNKEEKEEPVEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSTSKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide


Download         Length: 651 bp        

>NTDB_id=895831 R4704_RS10235 WP_001864147.1 1970434..1971084(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain 11012]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACACCTGTCAAAGAAACGAATTTGCAGGTTGAAGTTGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCAGTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAACAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

Helix-hairpin-helix motif (HHH_3)

(151-214)

SLBB domain (SLBB)

(76-126)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae Rx1

98.148

100

0.981
  comEA/celA/cilE Streptococcus pneumoniae D39

98.148

100

0.981
  comEA/celA/cilE Streptococcus pneumoniae R6

98.148

100

0.981
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

97.222

100

0.972
  comEA/celA/cilE Streptococcus mitis NCTC 12261

95.833

100

0.958
  comEA/celA/cilE Streptococcus mitis SK321

91.204

100

0.912
  comEA Lactococcus lactis subsp. cremoris KW2

43.612

100

0.458
  comEA Latilactobacillus sakei subsp. sakei 23K

33.906

100

0.366
  comEA Bacillus subtilis subsp. subtilis str. 168

41.579

87.963

0.366