Detailed information NTG0895785

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: R4704_RS04055
• Genome accession: NZ_CP137109
• Coordinates: 775228..776265 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain 11012
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 770228..781265

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4704_RS04030	-	771041..772372 (-)	1332	WP_000390042.1	hemolysin family protein	-
R4704_RS04035	endA	772589..773413 (-)	825	WP_001036786.1	DNA-entry nuclease EndA	Machinery gene
R4704_RS04040	-	773452..773640 (-)	189	WP_001813390.1	DNA-directed RNA polymerase subunit beta	-
R4704_RS04045	murA	773633..774916 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
R4704_RS04050	-	774940..775170 (-)	231	WP_000250384.1	DUF1146 family protein	-
R4704_RS04055	sepM	775228..776265 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
R4704_RS04060	coaD	776249..776737 (-)	489	WP_001280746.1	pantetheine-phosphate adenylyltransferase	-
R4704_RS04065	rsmD	776727..777266 (-)	540	WP_000706957.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
R4704_RS04070	asnA	777331..778323 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
R4704_RS04075	-	778434..779117 (-)	684	WP_001016913.1	Bax inhibitor-1/YccA family protein	-
R4704_RS04080	-	779173..779913 (-)	741	WP_000152704.1	RNA methyltransferase	-
R4704_RS04085	-	779947..780225 (+)	279	WP_001174613.1	acylphosphatase	-
R4704_RS04090	yidC	780303..781229 (+)	927	WP_000835941.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=895785 R4704_RS04055 WP_000727277.1 775228..776265(-) (sepM) [Streptococcus pneumoniae strain 11012]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=895785 R4704_RS04055 WP_000727277.1 775228..776265(-) (sepM) [Streptococcus pneumoniae strain 11012]
ATGAAAAAAAAGATTAGATGGCCTTTGTATGTCATTGCGGCCTTGATTGTGACCTTCTTGGCATTTGTGGTGCCTTTGCC
CTACTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCTACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591