Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   R4704_RS00580 Genome accession   NZ_CP137109
Coordinates   118606..119310 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain 11012     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 113606..124310
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4704_RS00555 - 113903..115789 (-) 1887 WP_000150984.1 Eco57I restriction-modification methylase domain-containing protein -
  R4704_RS00560 - 115864..116118 (-) 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin -
  R4704_RS00565 relB 116120..116362 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  R4704_RS00570 vicX 116453..117262 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  R4704_RS00575 micB 117264..118613 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  R4704_RS00580 micA 118606..119310 (-) 705 WP_000722076.1 response regulator YycF Regulator
  R4704_RS00585 mutY 119365..120540 (-) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  R4704_RS00590 - 120869..122539 (-) 1671 WP_000845290.1 formate--tetrahydrofolate ligase -
  R4704_RS00595 coaB 122769..123458 (+) 690 WP_000699488.1 phosphopantothenate--cysteine ligase -
  R4704_RS00600 coaC 123470..124021 (+) 552 WP_001284128.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=895760 R4704_RS00580 WP_000722076.1 118606..119310(-) (micA) [Streptococcus pneumoniae strain 11012]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=895760 R4704_RS00580 WP_000722076.1 118606..119310(-) (micA) [Streptococcus pneumoniae strain 11012]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACAAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38