Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   R4708_RS05415 Genome accession   NZ_CP137104
Coordinates   1071866..1073191 (+) Length   441 a.a.
NCBI ID   WP_000362880.1    Uniprot ID   Q79CK8
Organism   Streptococcus pneumoniae strain LM     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1066866..1078191
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4708_RS05385 dnaA 1067205..1068566 (-) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -
  R4708_RS05390 spo0J 1068779..1069537 (-) 759 WP_317829975.1 ParB/RepB/Spo0J family partition protein Regulator
  R4708_RS05395 htrA 1069595..1070776 (-) 1182 WP_000681597.1 S1C family serine protease Regulator
  R4708_RS05400 rlmH 1070959..1071438 (+) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  R4708_RS05410 comC/comC1 1071720..1071845 (+) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  R4708_RS05415 comD/comD1 1071866..1073191 (+) 1326 WP_000362880.1 competence system sensor histidine kinase ComD Regulator
  R4708_RS05420 comE 1073188..1073940 (+) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  R4708_RS05435 - 1074183..1074725 (-) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  R4708_RS05440 - 1074905..1075979 (+) 1075 Protein_1074 YhgE/Pip family protein -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51353.78 Da        Isoelectric Point: 6.6400

>NTDB_id=895396 R4708_RS05415 WP_000362880.1 1071866..1073191(+) (comD/comD1) [Streptococcus pneumoniae strain LM]
MDLFGFGTVIVHFLIISHSYHFICKGQINRKELFVFGAYTLLTEIVFDFPLYILYLDGLGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDEDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=895396 R4708_RS05415 WP_000362880.1 1071866..1073191(+) (comD/comD1) [Streptococcus pneumoniae strain LM]
ATGGATTTATTTGGATTTGGGACGGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCATTTTATTTGTAAAGGTCA
AATAAATAGAAAAGAATTATTCGTTTTTGGTGCTTATACATTACTAACAGAAATAGTATTTGATTTTCCCTTATATATTC
TATATTTAGATGGGTTAGGGATTGAAAGATTTTTATTTCCTTTGGGATTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTACTATTTCCATTTGGAACTAGCCTATTTTGACGAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q79CK8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

100

100

1
  comD/comD1 Streptococcus pneumoniae D39

100

100

1
  comD/comD1 Streptococcus pneumoniae R6

100

100

1
  comD/comD2 Streptococcus pneumoniae TIGR4

96.825

100

0.968
  comD Streptococcus mitis SK321

92.063

100

0.921
  comD Streptococcus mitis NCTC 12261

86.168

100

0.862
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.733

84.807

0.422
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.468

85.261

0.422