Detailed information    

insolico Bioinformatically predicted

Overview

Name   micB   Type   Regulator
Locus tag   R4713_RS10415 Genome accession   NZ_CP137103
Coordinates   2000596..2001945 (+) Length   449 a.a.
NCBI ID   WP_000886210.1    Uniprot ID   A0A064BZM9
Organism   Streptococcus pneumoniae strain 21334     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1995596..2006945
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4713_RS10395 coaB 1995751..1996440 (-) 690 WP_000699489.1 phosphopantothenate--cysteine ligase -
  R4713_RS10400 - 1996670..1998340 (+) 1671 WP_000845287.1 formate--tetrahydrofolate ligase -
  R4713_RS10405 mutY 1998669..1999844 (+) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  R4713_RS10410 micA 1999899..2000603 (+) 705 WP_000722076.1 response regulator YycF Regulator
  R4713_RS10415 micB 2000596..2001945 (+) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  R4713_RS10420 vicX 2001947..2002756 (+) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  R4713_RS10425 relB 2002847..2003089 (+) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  R4713_RS10430 - 2003091..2003345 (+) 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin -
  R4713_RS10435 - 2003392..2004165 (+) 774 WP_000731129.1 potassium channel family protein -
  R4713_RS10440 - 2004481..2005827 (-) 1347 WP_001814919.1 IS1380-like element ISSpn5 family transposase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 51712.42 Da        Isoelectric Point: 4.9706

>NTDB_id=895372 R4713_RS10415 WP_000886210.1 2000596..2001945(+) (micB) [Streptococcus pneumoniae strain 21334]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIW
MEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=895372 R4713_RS10415 WP_000886210.1 2000596..2001945(+) (micB) [Streptococcus pneumoniae strain 21334]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACCCTCTTATTACTGGAAAATAGACGTGATAATATTCAGTTGAAGCAAATCAATCAAAAGGTTAAAGATTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGGGTCTGAAATCACCAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGGCTAAATAGTATTCTGTTTTATATGACAGATGGGGT
TCTTGCGACCAACCGTCGGGGTCAGATTATCATGATTAACGATACAGCCAAGAAGCAACTGGGGTTGGTTAAGGAAGATG
TTCTGAATAGAAGCATTTTGGAATTGCTCAAGATAGAAGAAAACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGATATCAATGGCGAATATTTGAACCTTCGAGTTCGCTTTGCCTTGATACGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTT
CCAATGTTAGCCATGAGTTACGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAGACCAACCGTATGATGCGCATGGTGACGGATCTCCTCCA
TCTTTCACGTATTGATAATGCTACCAGTCACCTAGATGTGGAACTGATTAACTTCACTGCTTTTATTACCTTTATCCTCA
ATCGTTTTGACAAGATGAAAGGACAGGAAAAGGAGAAAAAATATGAGTTGGTGAGAGATTATCCCATCAATTCTATCTGG
ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCTATTAAGTATTCGCCAGATGGGGG
TAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATGATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGC
AGGATTTACCACGTATCTTTGACCGTTTCTATCGTGTGGATCGTGCTAGAAGTCGTGCACAAGGTGGTACAGGTCTAGGA
CTGTCTATCGCTAAAGAAATTATCAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAATACGGCAAGGGTTCAACCTT
TACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterproScan.

PAS fold (PAS)

(98-198)

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A064BZM9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micB Streptococcus pneumoniae Cp1015

99.777

100

0.998
  vicK Streptococcus mutans UA159

69.9

89.532

0.626