Detailed information    

insolico Bioinformatically predicted

Overview

Name   comM   Type   Regulator
Locus tag   R4713_RS03825 Genome accession   NZ_CP137103
Coordinates   722555..723175 (-) Length   206 a.a.
NCBI ID   WP_081574804.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 21334     
Function   fratricide immunity (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 711011..754926 722555..723175 within 0


Gene organization within MGE regions


Location: 711011..754926
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4713_RS03755 - 711308..711859 (-) 552 WP_001111247.1 hypothetical protein -
  R4713_RS03760 - 711849..712046 (-) 198 WP_000890144.1 hypothetical protein -
  R4713_RS03765 - 712050..712844 (-) 795 WP_001101215.1 hypothetical protein -
  R4713_RS03770 - 713252..713677 (-) 426 WP_000204068.1 hypothetical protein -
  R4713_RS03775 - 713806..714165 (-) 360 WP_000749821.1 ImmA/IrrE family metallo-endopeptidase -
  R4713_RS03780 - 714211..714417 (-) 207 WP_000366087.1 hypothetical protein -
  R4713_RS03785 - 714404..714565 (-) 162 WP_000289348.1 helix-turn-helix domain-containing protein -
  R4713_RS03790 lytA 714924..715880 (-) 957 WP_000405240.1 N-acetylmuramoyl-L-alanine amidase LytA -
  R4713_RS03795 - 716256..717626 (-) 1371 WP_001036271.1 MATE family efflux transporter -
  R4713_RS03800 recA 717933..719099 (-) 1167 WP_001085462.1 recombinase RecA Machinery gene
  R4713_RS03805 cinA 719154..720410 (-) 1257 WP_000642704.1 competence/damage-inducible protein A Machinery gene
  R4713_RS03810 brpA 720495..721511 (-) 1017 WP_081574805.1 biofilm formation/cell division transcriptional regulator BrpA -
  R4713_RS03815 - 721519..722037 (-) 519 WP_050253510.1 GNAT family N-acetyltransferase -
  R4713_RS03820 tsaE 722027..722470 (-) 444 WP_050314385.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  R4713_RS03825 comM 722555..723175 (-) 621 WP_081574804.1 hypothetical protein Regulator
  R4713_RS03830 - 723480..724343 (-) 864 WP_050223545.1 helix-turn-helix domain-containing protein -
  R4713_RS03835 - 724533..724703 (+) 171 WP_081574802.1 PhrA family quorum-sensing system peptide -
  R4713_RS03840 - 725105..725419 (+) 315 WP_000420682.1 YdcP family protein -
  R4713_RS03845 - 725435..725821 (+) 387 WP_000985015.1 YdcP family protein -
  R4713_RS03850 - 725850..727235 (+) 1386 WP_000813494.1 FtsK/SpoIIIE domain-containing protein -
  R4713_RS03855 - 727238..727390 (+) 153 WP_000879507.1 hypothetical protein -
  R4713_RS03860 mobT 727413..728675 (+) 1263 WP_001814870.1 MobT family relaxase -
  R4713_RS03865 - 728620..728832 (+) 213 WP_029645760.1 peptide-binding protein -
  R4713_RS03870 - 728881..728964 (+) 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
  R4713_RS03875 erm(B) 729089..729826 (+) 738 WP_001038795.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
  R4713_RS03880 - 730083..731330 (-) 1248 WP_000019067.1 ISL3 family transposase -
  R4713_RS03885 - 731510..731731 (+) 222 WP_001009056.1 hypothetical protein -
  R4713_RS03890 - 731848..732345 (+) 498 WP_000342539.1 antirestriction protein ArdA -
  R4713_RS03895 - 732434..732826 (+) 393 WP_000723888.1 conjugal transfer protein -
  R4713_RS03900 - 732810..735257 (+) 2448 WP_000331160.1 ATP-binding protein -
  R4713_RS03905 - 735260..737437 (+) 2178 WP_001814875.1 CD3337/EF1877 family mobilome membrane protein -
  R4713_RS03910 - 737434..738435 (+) 1002 WP_000769868.1 lysozyme family protein -
  R4713_RS03915 - 738432..739364 (+) 933 WP_001224318.1 conjugal transfer protein -
  R4713_RS10915 - 739678..739725 (+) 48 Protein_753 hypothetical protein -
  R4713_RS03925 tet(M) 739741..741660 (+) 1920 WP_000691729.1 tetracycline resistance ribosomal protection protein Tet(M) -
  R4713_RS03930 - 742024..742269 (+) 246 WP_001813542.1 hypothetical protein -
  R4713_RS03935 - 742266..742601 (+) 336 WP_000806926.1 hypothetical protein -
  R4713_RS03940 - 742614..742982 (+) 369 WP_000567222.1 hypothetical protein -
  R4713_RS03945 - 742969..743268 (+) 300 WP_001072467.1 DUF5960 family protein -
  R4713_RS03950 msr(D) 743386..744849 (-) 1464 WP_000420313.1 ABC-F type ribosomal protection protein Msr(D) -
  R4713_RS03955 mef(A) 744969..746186 (-) 1218 WP_000417519.1 macrolide efflux MFS transporter Mef(A) -
  R4713_RS03960 - 746572..746742 (-) 171 WP_000873143.1 hypothetical protein -
  R4713_RS03965 - 747264..747455 (+) 192 WP_001860868.1 cysteine-rich KTR domain-containing protein -
  R4713_RS03970 - 747515..747868 (-) 354 WP_001227347.1 helix-turn-helix transcriptional regulator -
  R4713_RS03975 - 748373..748795 (+) 423 WP_000804885.1 sigma-70 family RNA polymerase sigma factor -
  R4713_RS03980 - 748792..749022 (+) 231 WP_000857133.1 helix-turn-helix domain-containing protein -
  R4713_RS03985 - 749248..749499 (-) 252 WP_001845478.1 hypothetical protein -
  R4713_RS03990 - 749483..749686 (+) 204 WP_000814511.1 excisionase -
  R4713_RS03995 - 749768..750985 (+) 1218 WP_001291561.1 tyrosine-type recombinase/integrase -
  R4713_RS04000 - 751876..753891 (+) 2016 WP_000732395.1 DUF1430 domain-containing protein -
  R4713_RS04005 - 753893..754525 (+) 633 WP_000571425.1 ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 206 a.a.        Molecular weight: 23498.71 Da        Isoelectric Point: 10.1254

>NTDB_id=895328 R4713_RS03825 WP_081574804.1 722555..723175(-) (comM) [Streptococcus pneumoniae strain 21334]
MKSMRILFLLVLIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLLYSILLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYMRDLLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIATLIFF

Nucleotide


Download         Length: 621 bp        

>NTDB_id=895328 R4713_RS03825 WP_081574804.1 722555..723175(-) (comM) [Streptococcus pneumoniae strain 21334]
ATGAAATCAATGAGAATCTTATTTTTGTTAGTTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGTATGGTCTTTGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTTCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTCTTTACAGTATCCTGCTCTTA
ATTAATTTGTTAGGAGCTGTCCTTGTTTTGTCAGACAACTTGTTCATCAAAAATACGTTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTTTTCTTTCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACATGCGTGATTTGC
TTGCTATGCTAGACAGAAAAAAGACAGTTTTGGTGACTATTTTAGCAACACTTCTCTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATATTGGACTGGGTTTGTTTTTTGCAGCCTATCTTGTCCCGAATTCTGTTAAAAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGCTACGCTCATTTTCTTTTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comM Streptococcus pneumoniae D39

97.087

100

0.971
  comM Streptococcus pneumoniae R6

97.087

100

0.971
  comM Streptococcus pneumoniae TIGR4

97.087

100

0.971
  comM Streptococcus mitis SK321

39.487

94.66

0.374
  comM Streptococcus mitis NCTC 12261

38.974

94.66

0.369