Detailed information NTG0895270

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: R4709_RS06940
• Genome accession: NZ_CP137102
• Coordinates: 1340992..1342029 (+)
• Length: 345 a.a.
• NCBI ID: WP_000727268.1
• Uniprot ID: A0A0U0L8C3
• Organism: Streptococcus pneumoniae strain 16H3071-2
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1335992..1347029

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4709_RS06905	yidC	1336027..1336953 (-)	927	WP_000835942.1	membrane protein insertase YidC	-
R4709_RS06910	-	1337031..1337309 (-)	279	WP_001174613.1	acylphosphatase	-
R4709_RS06915	-	1337343..1338083 (+)	741	WP_000152693.1	RNA methyltransferase	-
R4709_RS06920	-	1338139..1338822 (+)	684	WP_001016913.1	Bax inhibitor-1/YccA family protein	-
R4709_RS06925	asnA	1338934..1339926 (+)	993	WP_000747993.1	aspartate--ammonia ligase	-
R4709_RS06930	rsmD	1339991..1340530 (+)	540	WP_000706960.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
R4709_RS06935	coaD	1340520..1341008 (+)	489	WP_001280723.1	pantetheine-phosphate adenylyltransferase	-
R4709_RS06940	sepM	1340992..1342029 (+)	1038	WP_000727268.1	SepM family pheromone-processing serine protease	Regulator
R4709_RS06945	-	1342087..1342317 (+)	231	WP_000250393.1	DUF1146 family protein	-
R4709_RS06950	murA	1342341..1343624 (+)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
R4709_RS06955	-	1343617..1343805 (+)	189	WP_001813390.1	DNA-directed RNA polymerase subunit beta	-
R4709_RS06960	endA	1343844..1344668 (+)	825	WP_001036783.1	DNA-entry nuclease EndA	Machinery gene
R4709_RS06965	-	1344959..1346290 (+)	1332	WP_000390043.1	hemolysin family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37551.60 Da
• Isoelectric Point: 5.0724

>NTDB_id=895270 R4709_RS06940 WP_000727268.1 1340992..1342029(+) (sepM) [Streptococcus pneumoniae strain 16H3071-2]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKINDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=895270 R4709_RS06940 WP_000727268.1 1340992..1342029(+) (sepM) [Streptococcus pneumoniae strain 16H3071-2]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAATAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTAGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

• PDZ domain (PDZ_2) (130-193)

3D structure

• AlphaFold DB: A0A0U0L8C3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.357	99.13	0.588