Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   R4714_RS08110 Genome accession   NZ_CP137099
Coordinates   1530421..1531158 (+) Length   245 a.a.
NCBI ID   WP_001219123.1    Uniprot ID   A0A4J1SVB2
Organism   Streptococcus pneumoniae strain 20824-4     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1525421..1536158
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4714_RS08075 - 1526352..1526591 (-) 240 WP_001812223.1 hypothetical protein -
  R4714_RS08080 - 1526753..1527040 (-) 288 WP_000777760.1 hypothetical protein -
  R4714_RS08085 - 1527050..1527460 (-) 411 WP_001278301.1 HIT family protein -
  R4714_RS08090 pptA 1527528..1528259 (+) 732 WP_000889919.1 ABC transporter ATP-binding protein Regulator
  R4714_RS08095 - 1528256..1529305 (+) 1050 WP_000653766.1 ABC transporter permease -
  R4714_RS08100 - 1529473..1529802 (-) 330 WP_000132572.1 hypothetical protein -
  R4714_RS08105 - 1530078..1530416 (+) 339 WP_000876670.1 LytTR family DNA-binding domain-containing protein -
  R4714_RS08110 comE/blpR 1530421..1531158 (+) 738 WP_001219123.1 response regulator transcription factor Regulator
  R4714_RS08115 - 1531172..1532512 (+) 1341 WP_219576932.1 sensor histidine kinase -
  R4714_RS08120 blpC 1532557..1532712 (-) 156 WP_000358810.1 quorum-sensing system pheromone BlpC -
  R4714_RS08125 - 1532769..1534130 (-) 1362 WP_054369799.1 bacteriocin secretion accessory protein -
  R4714_RS08130 blpA 1534141..1534770 (-) 630 Protein_1553 peptide cleavage/export ABC transporter BlpA -
  R4714_RS08135 - 1534712..1535101 (+) 390 WP_398579032.1 hypothetical protein -
  R4714_RS08140 - 1535730..1536113 (+) 384 WP_000877381.1 hypothetical protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28784.92 Da        Isoelectric Point: 6.2361

>NTDB_id=895051 R4714_RS08110 WP_001219123.1 1530421..1531158(+) (comE/blpR) [Streptococcus pneumoniae strain 20824-4]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETDLLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=895051 R4714_RS08110 WP_001219123.1 1530421..1531158(+) (comE/blpR) [Streptococcus pneumoniae strain 20824-4]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGAATCGAGACAGACCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCTCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTTTTTCCCAATGGTGGAAGTTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4J1SVB2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.909

99.184

0.535
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.43

98.776

0.38