Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpX   Type   Regulator
Locus tag   R3H37_RS05635 Genome accession   NZ_CP136948
Coordinates   1127337..1128566 (-) Length   409 a.a.
NCBI ID   WP_002984948.1    Uniprot ID   A0A4U7GJW1
Organism   Streptococcus pyogenes strain Spyo01     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1122337..1133566
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R3H37_RS05615 (R3H37_05615) rpiA 1122617..1123300 (-) 684 WP_009881270.1 ribose-5-phosphate isomerase RpiA -
  R3H37_RS05620 (R3H37_05620) - 1123679..1125778 (+) 2100 WP_136107909.1 AAA family ATPase -
  R3H37_RS05625 (R3H37_05625) - 1125837..1126580 (-) 744 WP_002984942.1 hypothetical protein -
  R3H37_RS05630 (R3H37_05630) yihA 1126728..1127327 (-) 600 WP_136107908.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  R3H37_RS05635 (R3H37_05635) clpX 1127337..1128566 (-) 1230 WP_002984948.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  R3H37_RS05640 (R3H37_05640) - 1128696..1128866 (-) 171 WP_002990165.1 hypothetical protein -
  R3H37_RS05645 (R3H37_05645) - 1128886..1129383 (-) 498 WP_002984955.1 dihydrofolate reductase -
  R3H37_RS05650 (R3H37_05650) - 1129463..1130302 (-) 840 WP_011017679.1 thymidylate synthase -
  R3H37_RS05655 (R3H37_05655) - 1130511..1131686 (+) 1176 WP_021340971.1 hydroxymethylglutaryl-CoA synthase -
  R3H37_RS05660 (R3H37_05660) - 1131673..1132950 (+) 1278 WP_002984963.1 hydroxymethylglutaryl-CoA reductase, degradative -

Sequence

Protein


Download         Length: 409 a.a.        Molecular weight: 44991.44 Da        Isoelectric Point: 4.5775

>NTDB_id=893610 R3H37_RS05635 WP_002984948.1 1127337..1128566(-) (clpX) [Streptococcus pyogenes strain Spyo01]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIQI
LTEPRNALVKQYQALLSYDGVELAFDKEALEAIANKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide


Download         Length: 1230 bp        

>NTDB_id=893610 R3H37_RS05635 WP_002984948.1 1127337..1128566(-) (clpX) [Streptococcus pyogenes strain Spyo01]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGGCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCTAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATTGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTAAACACATCAGATTTGATTCAAATT
TTGACAGAACCAAGAAATGCCCTGGTCAAGCAATATCAGGCCCTTCTTTCTTACGATGGCGTCGAATTGGCATTTGATAA
GGAAGCCTTAGAAGCCATTGCCAATAAAGCCATTGAACGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATTGAAGAAA
CGATGTTAGACATTATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(110-305)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(312-391)

ClpX C4-type zinc finger (zf-C4_ClpX)

(12-48)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4U7GJW1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpX Streptococcus mutans UA159

88.998

100

0.89
  clpX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.603

98.044

0.575