Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   AAIS09_RS01880 Genome accession   NZ_CP154595
Coordinates   361183..361815 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain serotype 4     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 356183..366815
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAIS09_RS01855 (AAIS09_01850) mvaD 356460..357413 (+) 954 WP_000373456.1 diphosphomevalonate decarboxylase -
  AAIS09_RS01860 (AAIS09_01855) - 357400..358407 (+) 1008 WP_061813483.1 phosphomevalonate kinase -
  AAIS09_RS01865 (AAIS09_01860) fni 358391..359401 (+) 1011 WP_050117841.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  AAIS09_RS01870 (AAIS09_01865) liaF 359479..360177 (+) 699 WP_001224640.1 cell wall-active antibiotics response protein LiaF -
  AAIS09_RS01875 (AAIS09_01870) - 360174..361169 (+) 996 WP_057485887.1 sensor histidine kinase -
  AAIS09_RS01880 (AAIS09_01875) vraR 361183..361815 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  AAIS09_RS01885 (AAIS09_01880) - 361816..362058 (+) 243 Protein_368 DNA alkylation repair protein -
  AAIS09_RS01890 (AAIS09_01885) - 361983..362585 (+) 603 Protein_369 DNA alkylation repair protein -
  AAIS09_RS01895 (AAIS09_01890) - 363044..363646 (+) 603 Protein_370 trypsin-like serine peptidase -
  AAIS09_RS01900 (AAIS09_01895) - 364002..364307 (+) 306 WP_001821501.1 tyrosine-type recombinase/integrase -
  AAIS09_RS01905 (AAIS09_01900) tig 364501..365784 (+) 1284 WP_000116465.1 trigger factor -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=893437 AAIS09_RS01880 WP_000698434.1 361183..361815(+) (vraR) [Streptococcus pneumoniae strain serotype 4]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=893437 AAIS09_RS01880 WP_000698434.1 361183..361815(+) (vraR) [Streptococcus pneumoniae strain serotype 4]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGTTTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41