Detailed information
Bioinformatically predicted
Overview
| Name | comK/comK1 | Type | Regulator |
| Locus tag | RGC89_RS03525 | Genome accession | NZ_CP133663 |
| Coordinates | 773514..774089 (+) | Length | 191 a.a. |
| NCBI ID | WP_001829272.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain AR4072 | ||
| Function | promote expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 774490..818213 | 773514..774089 | flank | 401 |
Gene organization within MGE regions
Location: 773514..818213
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RGC89_RS03525 (RGC89_03525) | comK/comK1 | 773514..774089 (+) | 576 | WP_001829272.1 | competence protein ComK | Regulator |
| RGC89_RS03540 (RGC89_03540) | - | 774490..775539 (-) | 1050 | WP_002468743.1 | site-specific integrase | - |
| RGC89_RS03545 (RGC89_03545) | - | 775650..775847 (+) | 198 | WP_002497576.1 | hypothetical protein | - |
| RGC89_RS03550 (RGC89_03550) | - | 775844..776251 (-) | 408 | WP_002497577.1 | TIR domain-containing protein | - |
| RGC89_RS03555 (RGC89_03555) | - | 776245..776682 (-) | 438 | WP_002497578.1 | DUF4231 domain-containing protein | - |
| RGC89_RS03560 (RGC89_03560) | - | 776794..777450 (-) | 657 | WP_309478165.1 | hypothetical protein | - |
| RGC89_RS03565 (RGC89_03565) | - | 777469..777930 (-) | 462 | WP_309478166.1 | ImmA/IrrE family metallo-endopeptidase | - |
| RGC89_RS03570 (RGC89_03570) | - | 777943..778266 (-) | 324 | WP_002485814.1 | helix-turn-helix domain-containing protein | - |
| RGC89_RS03575 (RGC89_03575) | - | 778432..778680 (+) | 249 | WP_002485846.1 | helix-turn-helix domain-containing protein | - |
| RGC89_RS03580 (RGC89_03580) | - | 778698..778838 (+) | 141 | WP_002485815.1 | hypothetical protein | - |
| RGC89_RS03585 (RGC89_03585) | - | 778831..779055 (-) | 225 | WP_032603937.1 | hypothetical protein | - |
| RGC89_RS03590 (RGC89_03590) | - | 779104..779988 (+) | 885 | WP_309478167.1 | hypothetical protein | - |
| RGC89_RS03595 (RGC89_03595) | - | 780001..780495 (+) | 495 | WP_309478168.1 | ORF6C domain-containing protein | - |
| RGC89_RS03600 (RGC89_03600) | - | 780531..780764 (+) | 234 | WP_309478169.1 | MW1434 family type I TA system toxin | - |
| RGC89_RS03605 (RGC89_03605) | - | 780924..781073 (+) | 150 | WP_309478170.1 | hypothetical protein | - |
| RGC89_RS03610 (RGC89_03610) | - | 781120..781296 (+) | 177 | WP_002456867.1 | hypothetical protein | - |
| RGC89_RS03615 (RGC89_03615) | - | 781358..781609 (+) | 252 | WP_309478171.1 | hypothetical protein | - |
| RGC89_RS03620 (RGC89_03620) | - | 781602..782087 (+) | 486 | WP_309478172.1 | siphovirus Gp157 family protein | - |
| RGC89_RS03625 (RGC89_03625) | - | 782088..782864 (+) | 777 | WP_309478173.1 | ATP-binding protein | - |
| RGC89_RS03630 (RGC89_03630) | - | 782893..783447 (+) | 555 | WP_309478174.1 | single-stranded DNA-binding protein | - |
| RGC89_RS03635 (RGC89_03635) | - | 783459..784133 (+) | 675 | WP_309478175.1 | putative HNHc nuclease | - |
| RGC89_RS03640 (RGC89_03640) | - | 784308..784715 (-) | 408 | WP_309478176.1 | hypothetical protein | - |
| RGC89_RS03645 (RGC89_03645) | - | 784764..785483 (+) | 720 | WP_309478177.1 | helix-turn-helix domain-containing protein | - |
| RGC89_RS03650 (RGC89_03650) | - | 785494..786264 (+) | 771 | WP_373880478.1 | ATP-binding protein | - |
| RGC89_RS03655 (RGC89_03655) | - | 786258..786419 (+) | 162 | WP_309478178.1 | hypothetical protein | - |
| RGC89_RS03660 (RGC89_03660) | - | 786419..786664 (+) | 246 | WP_002497109.1 | hypothetical protein | - |
| RGC89_RS03665 (RGC89_03665) | - | 786674..787090 (+) | 417 | WP_309478179.1 | DUF1064 domain-containing protein | - |
| RGC89_RS03670 (RGC89_03670) | - | 787077..787451 (+) | 375 | WP_002484718.1 | hypothetical protein | - |
| RGC89_RS03675 (RGC89_03675) | - | 787451..787642 (+) | 192 | WP_002484773.1 | hypothetical protein | - |
| RGC89_RS03680 (RGC89_03680) | - | 787643..788002 (+) | 360 | WP_002484760.1 | SA1788 family PVL leukocidin-associated protein | - |
| RGC89_RS03685 (RGC89_03685) | - | 787999..788451 (+) | 453 | WP_002484724.1 | DUF3310 domain-containing protein | - |
| RGC89_RS03690 (RGC89_03690) | - | 788441..788728 (+) | 288 | WP_002484753.1 | hypothetical protein | - |
| RGC89_RS03695 (RGC89_03695) | - | 788744..789424 (+) | 681 | WP_002504784.1 | hypothetical protein | - |
| RGC89_RS03700 (RGC89_03700) | - | 789421..789606 (+) | 186 | WP_002500115.1 | hypothetical protein | - |
| RGC89_RS03705 (RGC89_03705) | - | 789594..789950 (+) | 357 | WP_373880479.1 | thermonuclease family protein | - |
| RGC89_RS03710 (RGC89_03710) | - | 789953..790261 (+) | 309 | WP_309478180.1 | hypothetical protein | - |
| RGC89_RS03715 (RGC89_03715) | - | 790262..790546 (+) | 285 | WP_309478181.1 | hypothetical protein | - |
| RGC89_RS03720 (RGC89_03720) | - | 790539..790823 (+) | 285 | WP_309478182.1 | hypothetical protein | - |
| RGC89_RS03725 (RGC89_03725) | dut | 790824..791246 (+) | 423 | WP_309478183.1 | dUTP diphosphatase | - |
| RGC89_RS03730 (RGC89_03730) | - | 791343..791645 (-) | 303 | WP_002499245.1 | DUF4870 domain-containing protein | - |
| RGC89_RS03735 (RGC89_03735) | rinB | 791750..791932 (+) | 183 | WP_002502052.1 | transcriptional activator RinB | - |
| RGC89_RS03740 (RGC89_03740) | - | 791933..792082 (+) | 150 | WP_002502053.1 | DUF1514 domain-containing protein | - |
| RGC89_RS03745 (RGC89_03745) | - | 792099..792545 (+) | 447 | WP_002502054.1 | transcriptional regulator | - |
| RGC89_RS03750 (RGC89_03750) | - | 793028..793378 (+) | 351 | WP_002502055.1 | HNH endonuclease | - |
| RGC89_RS03755 (RGC89_03755) | - | 793538..794023 (+) | 486 | WP_002502056.1 | phage terminase small subunit P27 family | - |
| RGC89_RS03760 (RGC89_03760) | - | 794016..795767 (+) | 1752 | WP_049404235.1 | terminase large subunit | - |
| RGC89_RS03765 (RGC89_03765) | - | 795783..795977 (+) | 195 | WP_002502058.1 | hypothetical protein | - |
| RGC89_RS03770 (RGC89_03770) | - | 795977..797209 (+) | 1233 | WP_002502059.1 | phage portal protein | - |
| RGC89_RS03775 (RGC89_03775) | - | 797199..797756 (+) | 558 | WP_002497603.1 | HK97 family phage prohead protease | - |
| RGC89_RS03780 (RGC89_03780) | - | 797798..799123 (+) | 1326 | WP_002502060.1 | phage major capsid protein | - |
| RGC89_RS03785 (RGC89_03785) | - | 799142..799483 (+) | 342 | WP_002502061.1 | head-tail connector protein | - |
| RGC89_RS03790 (RGC89_03790) | - | 799473..799802 (+) | 330 | WP_002502062.1 | head-tail adaptor protein | - |
| RGC89_RS03795 (RGC89_03795) | - | 799937..800203 (+) | 267 | WP_002502063.1 | hypothetical protein | - |
| RGC89_RS03800 (RGC89_03800) | - | 800206..800610 (+) | 405 | WP_002502064.1 | hypothetical protein | - |
| RGC89_RS03805 (RGC89_03805) | - | 800623..801249 (+) | 627 | WP_002499234.1 | major tail protein | - |
| RGC89_RS03810 (RGC89_03810) | - | 801268..801453 (+) | 186 | WP_049367138.1 | hypothetical protein | - |
| RGC89_RS03815 (RGC89_03815) | gpG | 801517..801879 (+) | 363 | WP_049367139.1 | phage tail assembly chaperone G | - |
| RGC89_RS03820 (RGC89_03820) | gpGT | 801912..802064 (+) | 153 | WP_002502068.1 | phage tail assembly chaperone GT | - |
| RGC89_RS03825 (RGC89_03825) | - | 802093..806589 (+) | 4497 | WP_309478184.1 | tape measure protein | - |
| RGC89_RS03830 (RGC89_03830) | - | 806591..807424 (+) | 834 | WP_049367142.1 | phage tail domain-containing protein | - |
| RGC89_RS03835 (RGC89_03835) | - | 807434..808993 (+) | 1560 | WP_002502071.1 | prophage endopeptidase tail family protein | - |
| RGC89_RS03840 (RGC89_03840) | - | 808986..809159 (+) | 174 | WP_002502072.1 | hypothetical protein | - |
| RGC89_RS03845 (RGC89_03845) | - | 809175..811037 (+) | 1863 | WP_002502073.1 | M14 family metallopeptidase | - |
| RGC89_RS03850 (RGC89_03850) | - | 811037..812251 (+) | 1215 | WP_002502074.1 | BppU family phage baseplate upper protein | - |
| RGC89_RS03855 (RGC89_03855) | - | 812256..812879 (+) | 624 | WP_070673728.1 | poly-gamma-glutamate hydrolase family protein | - |
| RGC89_RS03860 (RGC89_03860) | - | 812876..813301 (+) | 426 | WP_002502076.1 | hypothetical protein | - |
| RGC89_RS03865 (RGC89_03865) | - | 813288..813695 (+) | 408 | WP_002502077.1 | hypothetical protein | - |
| RGC89_RS03870 (RGC89_03870) | - | 813853..814251 (+) | 399 | WP_032606342.1 | YxeA family protein | - |
| RGC89_RS03875 (RGC89_03875) | - | 814315..814725 (+) | 411 | WP_002502079.1 | phage holin | - |
| RGC89_RS03880 (RGC89_03880) | - | 814700..816163 (+) | 1464 | WP_049367144.1 | SH3 domain-containing protein | - |
| RGC89_RS03885 (RGC89_03885) | - | 816647..817444 (+) | 798 | WP_049367145.1 | HipA family kinase | - |
| RGC89_RS03890 (RGC89_03890) | - | 817446..818213 (+) | 768 | WP_049367147.1 | hypothetical protein | - |
Sequence
Protein
Download Length: 191 a.a. Molecular weight: 22782.87 Da Isoelectric Point: 9.2887
>NTDB_id=875715 RGC89_RS03525 WP_001829272.1 773514..774089(+) (comK/comK1) [Staphylococcus epidermidis strain AR4072]
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
Nucleotide
Download Length: 576 bp
>NTDB_id=875715 RGC89_RS03525 WP_001829272.1 773514..774089(+) (comK/comK1) [Staphylococcus epidermidis strain AR4072]
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comK/comK1 | Staphylococcus aureus MW2 |
76.757 |
96.859 |
0.743 |
| comK/comK1 | Staphylococcus aureus N315 |
76.757 |
96.859 |
0.743 |