Detailed information NTG0874120

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: RDJ18_RS05360
• Genome accession: NZ_CP133442
• Coordinates: 1044424..1045467 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017127.1
• Uniprot ID: A0A1L6C0A3
• Organism: Staphylococcus aureus strain SA191
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1039424..1050467

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RDJ18_RS05330 (RDJ18_05330)	-	1039853..1039963 (+)	111	WP_001790257.1	hypothetical protein	-
RDJ18_RS05335 (RDJ18_05335)	-	1039992..1040405 (+)	414	WP_001549145.1	hypothetical protein	-
RDJ18_RS05340 (RDJ18_05340)	-	1040836..1041822 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
RDJ18_RS05345 (RDJ18_05345)	map	1042350..1043108 (+)	759	WP_000636146.1	type I methionyl aminopeptidase	-
RDJ18_RS05350 (RDJ18_05350)	-	1043325..1043711 (+)	387	WP_001110179.1	hypothetical protein	-
RDJ18_RS05355 (RDJ18_05355)	liaF	1043726..1044427 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
RDJ18_RS05360 (RDJ18_05360)	vraS	1044424..1045467 (+)	1044	WP_001017127.1	sensor histidine kinase	Regulator
RDJ18_RS05365 (RDJ18_05365)	vraR	1045457..1046086 (+)	630	WP_000153525.1	two-component system response regulator VraR	Regulator
RDJ18_RS05370 (RDJ18_05370)	-	1046202..1047419 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
RDJ18_RS05375 (RDJ18_05375)	-	1047697..1047972 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
RDJ18_RS05380 (RDJ18_05380)	-	1047979..1048443 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
RDJ18_RS05385 (RDJ18_05385)	-	1048590..1048790 (+)	201	WP_000180461.1	DUF1128 family protein	-
RDJ18_RS05390 (RDJ18_05390)	-	1048793..1050049 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40002.44 Da
• Isoelectric Point: 6.0577

>NTDB_id=874120 RDJ18_RS05360 WP_001017127.1 1044424..1045467(+) (vraS) [Staphylococcus aureus strain SA191]
MNHYIRTIGSMLILGYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=874120 RDJ18_RS05360 WP_001017127.1 1044424..1045467(+) (vraS) [Staphylococcus aureus strain SA191]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGGATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A1L6C0A3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	99.712	100	0.997