Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   WHU57_RS12385 Genome accession   NZ_CP148323
Coordinates   2525618..2526274 (-) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain Z1323HEC0477     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2520618..2531274
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  WHU57_RS12355 (WHU57_12355) yecA 2521869..2522534 (-) 666 WP_000847877.1 UPF0149 family protein YecA -
  WHU57_RS12375 (WHU57_12375) pgsA 2523184..2523732 (-) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  WHU57_RS12380 (WHU57_12380) uvrC 2523789..2525621 (-) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  WHU57_RS12385 (WHU57_12385) letA 2525618..2526274 (-) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  WHU57_RS12390 (WHU57_12390) yecU 2526570..2526746 (+) 177 WP_001307856.1 protein YecU -
  WHU57_RS12395 (WHU57_12395) yecF 2526733..2526957 (+) 225 WP_000106474.1 DUF2594 family protein YecF -
  WHU57_RS12400 (WHU57_12400) sdiA 2527025..2527747 (-) 723 WP_001154255.1 transcriptional regulator SdiA -
  WHU57_RS12405 (WHU57_12405) tcyN 2527977..2528729 (-) 753 WP_001273000.1 L-cystine ABC transporter ATP-binding protein TcyN -
  WHU57_RS12410 (WHU57_12410) tcyL 2528726..2529394 (-) 669 WP_001158220.1 cystine ABC transporter permease -
  WHU57_RS12415 (WHU57_12415) dcyD 2529409..2530395 (-) 987 WP_001128230.1 D-cysteine desulfhydrase -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=870155 WHU57_RS12385 WP_000611328.1 2525618..2526274(-) (letA) [Escherichia coli strain Z1323HEC0477]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=870155 WHU57_RS12385 WP_000611328.1 2525618..2526274(-) (letA) [Escherichia coli strain Z1323HEC0477]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGAGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCACAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGATATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482