Detailed information
Bioinformatically predicted
Overview
| Name | comM | Type | Regulator |
| Locus tag | Q7622_RS08990 | Genome accession | NZ_CP131711 |
| Coordinates | 1760889..1761509 (-) | Length | 206 a.a. |
| NCBI ID | WP_000839909.1 | Uniprot ID | A0A098Z2X2 |
| Organism | Streptococcus pneumoniae strain 2014C08-275 | ||
| Function | fratricide immunity (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1749344..1793263 | 1760889..1761509 | within | 0 |
Gene organization within MGE regions
Location: 1749344..1793263
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Q7622_RS08920 (Q7622_08890) | - | 1749641..1750192 (-) | 552 | WP_001111247.1 | hypothetical protein | - |
| Q7622_RS08925 (Q7622_08895) | - | 1750182..1750379 (-) | 198 | WP_000890144.1 | hypothetical protein | - |
| Q7622_RS08930 (Q7622_08900) | - | 1750383..1751177 (-) | 795 | WP_001101215.1 | hypothetical protein | - |
| Q7622_RS08935 (Q7622_08905) | - | 1751585..1752010 (-) | 426 | WP_000204068.1 | hypothetical protein | - |
| Q7622_RS08940 (Q7622_08910) | - | 1752139..1752498 (-) | 360 | WP_000749821.1 | hypothetical protein | - |
| Q7622_RS08945 (Q7622_08915) | - | 1752544..1752750 (-) | 207 | WP_000366087.1 | hypothetical protein | - |
| Q7622_RS08950 (Q7622_08920) | - | 1752737..1752898 (-) | 162 | WP_000289348.1 | helix-turn-helix transcriptional regulator | - |
| Q7622_RS08955 (Q7622_08925) | lytA | 1753257..1754213 (-) | 957 | WP_000405240.1 | N-acetylmuramoyl-L-alanine amidase LytA | - |
| Q7622_RS08960 (Q7622_08930) | - | 1754589..1755959 (-) | 1371 | WP_341989084.1 | MATE family efflux transporter | - |
| Q7622_RS08965 (Q7622_08935) | recA | 1756266..1757432 (-) | 1167 | WP_001085462.1 | recombinase RecA | Machinery gene |
| Q7622_RS08970 (Q7622_08940) | cinA | 1757487..1758743 (-) | 1257 | WP_000642704.1 | competence/damage-inducible protein A | Machinery gene |
| Q7622_RS08975 (Q7622_08945) | - | 1758828..1759844 (-) | 1017 | WP_000239278.1 | LCP family protein | - |
| Q7622_RS08980 (Q7622_08950) | - | 1759852..1760370 (-) | 519 | WP_000455536.1 | GNAT family N-acetyltransferase | - |
| Q7622_RS08985 (Q7622_08955) | tsaE | 1760360..1760803 (-) | 444 | WP_000288230.1 | tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE | - |
| Q7622_RS08990 (Q7622_08960) | comM | 1760889..1761509 (-) | 621 | WP_000839909.1 | hypothetical protein | Regulator |
| Q7622_RS08995 (Q7622_08965) | - | 1761815..1762678 (-) | 864 | WP_001093609.1 | helix-turn-helix transcriptional regulator | - |
| Q7622_RS09000 (Q7622_08970) | - | 1762870..1763040 (+) | 171 | WP_001227863.1 | PhrA family quorum-sensing system peptide | - |
| Q7622_RS09005 (Q7622_08975) | - | 1763442..1763756 (+) | 315 | WP_000420682.1 | YdcP family protein | - |
| Q7622_RS09010 (Q7622_08980) | - | 1763772..1764158 (+) | 387 | WP_000985015.1 | YdcP family protein | - |
| Q7622_RS09015 (Q7622_08985) | - | 1764187..1765572 (+) | 1386 | WP_000813494.1 | FtsK/SpoIIIE domain-containing protein | - |
| Q7622_RS09020 (Q7622_08990) | - | 1765575..1765727 (+) | 153 | WP_000879507.1 | hypothetical protein | - |
| Q7622_RS09025 (Q7622_08995) | mobT | 1765750..1767012 (+) | 1263 | WP_001814870.1 | MobT family relaxase | - |
| Q7622_RS09030 (Q7622_09000) | - | 1766957..1767169 (+) | 213 | WP_029645760.1 | peptide-binding protein | - |
| Q7622_RS09035 (Q7622_09005) | - | 1767218..1767301 (+) | 84 | WP_001814874.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
| Q7622_RS09040 (Q7622_09010) | erm(B) | 1767426..1768163 (+) | 738 | WP_001038795.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| Q7622_RS09045 (Q7622_09015) | - | 1768420..1769667 (-) | 1248 | WP_000019067.1 | ISL3 family transposase | - |
| Q7622_RS09050 (Q7622_09020) | - | 1769847..1770068 (+) | 222 | WP_001009056.1 | hypothetical protein | - |
| Q7622_RS09055 (Q7622_09025) | - | 1770185..1770682 (+) | 498 | WP_000342539.1 | antirestriction protein ArdA | - |
| Q7622_RS09060 (Q7622_09030) | - | 1770771..1771163 (+) | 393 | WP_000723888.1 | conjugal transfer protein | - |
| Q7622_RS09065 (Q7622_09035) | - | 1771147..1773594 (+) | 2448 | WP_000331160.1 | ATP-binding protein | - |
| Q7622_RS09070 (Q7622_09040) | - | 1773597..1775774 (+) | 2178 | WP_001814875.1 | membrane protein | - |
| Q7622_RS09075 (Q7622_09045) | - | 1775771..1776772 (+) | 1002 | WP_000769868.1 | bifunctional lysozyme/C40 family peptidase | - |
| Q7622_RS09080 (Q7622_09050) | - | 1776769..1777701 (+) | 933 | WP_001224318.1 | conjugal transfer protein | - |
| Q7622_RS09085 (Q7622_09055) | - | 1777946..1778062 (+) | 117 | WP_001814923.1 | tetracycline resistance determinant leader peptide | - |
| Q7622_RS09090 (Q7622_09060) | tet(M) | 1778078..1779997 (+) | 1920 | WP_341989086.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| Q7622_RS09095 (Q7622_09065) | - | 1780361..1780606 (+) | 246 | WP_001813542.1 | hypothetical protein | - |
| Q7622_RS09100 (Q7622_09070) | - | 1780603..1780938 (+) | 336 | WP_000806926.1 | hypothetical protein | - |
| Q7622_RS09105 (Q7622_09075) | - | 1780951..1781319 (+) | 369 | WP_000567222.1 | hypothetical protein | - |
| Q7622_RS09110 (Q7622_09080) | - | 1781306..1781605 (+) | 300 | WP_001072467.1 | DUF5960 family protein | - |
| Q7622_RS09115 (Q7622_09085) | msr(D) | 1781723..1783186 (-) | 1464 | WP_000420313.1 | ABC-F type ribosomal protection protein Msr(D) | - |
| Q7622_RS09120 (Q7622_09090) | mef(A) | 1783306..1784523 (-) | 1218 | WP_000417519.1 | macrolide efflux MFS transporter Mef(A) | - |
| Q7622_RS09125 (Q7622_09095) | - | 1784909..1785079 (-) | 171 | WP_000873143.1 | hypothetical protein | - |
| Q7622_RS09130 (Q7622_09100) | - | 1785601..1785792 (+) | 192 | WP_001860868.1 | cysteine-rich KTR domain-containing protein | - |
| Q7622_RS09135 (Q7622_09105) | - | 1785852..1786205 (-) | 354 | WP_001227347.1 | helix-turn-helix transcriptional regulator | - |
| Q7622_RS09140 (Q7622_09110) | - | 1786710..1787132 (+) | 423 | WP_000804885.1 | sigma-70 family RNA polymerase sigma factor | - |
| Q7622_RS09145 (Q7622_09115) | - | 1787129..1787359 (+) | 231 | WP_000857133.1 | helix-turn-helix domain-containing protein | - |
| Q7622_RS09150 (Q7622_09120) | - | 1787585..1787836 (-) | 252 | WP_001845478.1 | hypothetical protein | - |
| Q7622_RS09155 (Q7622_09125) | - | 1787820..1788023 (+) | 204 | WP_000814511.1 | excisionase | - |
| Q7622_RS09160 (Q7622_09130) | - | 1788105..1789322 (+) | 1218 | WP_001291561.1 | tyrosine-type recombinase/integrase | - |
| Q7622_RS09165 (Q7622_09135) | - | 1790213..1792228 (+) | 2016 | WP_000732395.1 | DUF1430 domain-containing protein | - |
| Q7622_RS09170 (Q7622_09140) | - | 1792230..1792862 (+) | 633 | WP_000571425.1 | ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 206 a.a. Molecular weight: 23540.66 Da Isoelectric Point: 10.1254
>NTDB_id=864214 Q7622_RS08990 WP_000839909.1 1760889..1761509(-) (comM) [Streptococcus pneumoniae strain 2014C08-275]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
Nucleotide
Download Length: 621 bp
>NTDB_id=864214 Q7622_RS08990 WP_000839909.1 1760889..1761509(-) (comM) [Streptococcus pneumoniae strain 2014C08-275]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
Domains
No domain identified.
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comM | Streptococcus pneumoniae D39 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae R6 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae TIGR4 |
99.515 |
100 |
0.995 |
| comM | Streptococcus mitis NCTC 12261 |
38.462 |
94.66 |
0.364 |
| comM | Streptococcus mitis SK321 |
38.462 |
94.66 |
0.364 |