Detailed information NTG0864098

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: Q7623_RS02860
• Genome accession: NZ_CP131710
• Coordinates: 541931..542668 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain 2014S11-203
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 536931..547668

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7623_RS02825 (Q7623_02815)	-	536968..538224 (+)	1257	WP_000436608.1	ISL3 family transposase	-
Q7623_RS02830 (Q7623_02820)	-	538262..538549 (-)	288	WP_000777760.1	hypothetical protein	-
Q7623_RS02835 (Q7623_02825)	-	538559..538969 (-)	411	WP_001278300.1	HIT family protein	-
Q7623_RS02840 (Q7623_02830)	pptA	539037..539768 (+)	732	WP_000889925.1	ABC transporter ATP-binding protein	Regulator
Q7623_RS02845 (Q7623_02835)	-	539765..540814 (+)	1050	WP_000653767.1	ABC transporter permease	-
Q7623_RS02850 (Q7623_02840)	-	540982..541311 (-)	330	WP_000132572.1	hypothetical protein	-
Q7623_RS02855 (Q7623_02845)	-	541588..541926 (+)	339	WP_000682135.1	LytTR family DNA-binding domain-containing protein	-
Q7623_RS02860 (Q7623_02850)	comE/blpR	541931..542668 (+)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
Q7623_RS02865 (Q7623_02855)	-	542682..544022 (+)	1341	WP_001017638.1	sensor histidine kinase	-
Q7623_RS02870 (Q7623_02860)	blpC	544064..544219 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
Q7623_RS02875 (Q7623_02865)	-	544276..545637 (-)	1362	WP_001069091.1	bacteriocin secretion accessory protein	-
Q7623_RS02880 (Q7623_02870)	comA/nlmT	545648..547324 (-)	1677	WP_196299874.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=864098 Q7623_RS02860 WP_001219120.1 541931..542668(+) (comE/blpR) [Streptococcus pneumoniae strain 2014S11-203]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=864098 Q7623_RS02860 WP_001219120.1 541931..542668(+) (comE/blpR) [Streptococcus pneumoniae strain 2014S11-203]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363