Detailed information NTG0863281

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: Q7643_RS10060
• Genome accession: NZ_CP131649
• Coordinates: 2032505..2033548 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 2014S06-081
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2027505..2038548

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7643_RS10030 (Q7643_10025)	-	2027923..2029179 (-)	1257	WP_001795438.1	aminopeptidase	-
Q7643_RS10035 (Q7643_10030)	-	2029182..2029382 (-)	201	WP_000180461.1	DUF1128 family protein	-
Q7643_RS10040 (Q7643_10035)	-	2029529..2029993 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
Q7643_RS10045 (Q7643_10040)	-	2030000..2030275 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
Q7643_RS10050 (Q7643_10045)	-	2030553..2031770 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
Q7643_RS10055 (Q7643_10050)	vraR	2031886..2032515 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
Q7643_RS10060 (Q7643_10055)	vraS	2032505..2033548 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
Q7643_RS10065 (Q7643_10060)	liaF	2033545..2034246 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
Q7643_RS10070 (Q7643_10065)	-	2034261..2034647 (-)	387	WP_001110179.1	hypothetical protein	-
Q7643_RS10075 (Q7643_10070)	map	2034864..2035622 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
Q7643_RS10080 (Q7643_10075)	-	2036150..2037136 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
Q7643_RS10085 (Q7643_10080)	-	2037626..2038039 (-)	414	WP_001549145.1	hypothetical protein	-
Q7643_RS10090 (Q7643_10085)	-	2038068..2038178 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=863281 Q7643_RS10060 WP_001017131.1 2032505..2033548(-) (vraS) [Staphylococcus aureus strain 2014S06-081]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=863281 Q7643_RS10060 WP_001017131.1 2032505..2033548(-) (vraS) [Staphylococcus aureus strain 2014S06-081]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1