Detailed information
Bioinformatically predicted
Overview
| Name | comM | Type | Regulator |
| Locus tag | STYK_RS08980 | Genome accession | NZ_AP024523 |
| Coordinates | 1799640..1800269 (-) | Length | 209 a.a. |
| NCBI ID | WP_004239116.1 | Uniprot ID | A0AAX2L3W1 |
| Organism | Streptococcus toyakuensis strain TP1632 | ||
| Function | fratricide immunity (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1800852..1862443 | 1799640..1800269 | flank | 583 |
Gene organization within MGE regions
Location: 1799640..1862443
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| STYK_RS08980 (STYK_17250) | comM | 1799640..1800269 (-) | 630 | WP_004239116.1 | hypothetical protein | Regulator |
| STYK_RS08985 (STYK_17260) | ndk | 1800402..1800824 (-) | 423 | WP_004239114.1 | nucleoside-diphosphate kinase | - |
| STYK_RS08990 (STYK_17270) | rpoC | 1801130..1804807 (-) | 3678 | WP_261804924.1 | DNA-directed RNA polymerase subunit beta' | - |
| STYK_RS08995 (STYK_17280) | rpoB | 1804846..1808451 (-) | 3606 | WP_120769758.1 | DNA-directed RNA polymerase subunit beta | - |
| STYK_RS09000 (STYK_17290) | - | 1809344..1812388 (+) | 3045 | WP_261019936.1 | SrtB-anchored collagen-binding adhesin | - |
| STYK_RS09005 (STYK_17300) | - | 1812624..1812950 (+) | 327 | WP_080821326.1 | YdcP family protein | - |
| STYK_RS09010 (STYK_17310) | - | 1812966..1813349 (+) | 384 | WP_144209880.1 | YdcP family protein | - |
| STYK_RS09015 (STYK_17320) | - | 1813446..1813904 (+) | 459 | WP_095905707.1 | VOC family protein | - |
| STYK_RS09020 (STYK_17330) | - | 1813995..1815389 (+) | 1395 | WP_144209884.1 | FtsK/SpoIIIE domain-containing protein | - |
| STYK_RS09025 | - | 1815359..1815544 (+) | 186 | WP_257329250.1 | conjugal transfer protein | - |
| STYK_RS09030 (STYK_17340) | mobT | 1815567..1816772 (+) | 1206 | WP_000398284.1 | MobT family relaxase | - |
| STYK_RS09035 (STYK_17350) | - | 1816815..1817036 (+) | 222 | WP_001009056.1 | hypothetical protein | - |
| STYK_RS09040 (STYK_17360) | - | 1817153..1817650 (+) | 498 | WP_000342539.1 | antirestriction protein ArdA | - |
| STYK_RS09045 (STYK_17370) | - | 1817739..1818130 (+) | 392 | Protein_1733 | conjugal transfer protein | - |
| STYK_RS09050 (STYK_17380) | - | 1818114..1820561 (+) | 2448 | WP_000331160.1 | ATP-binding protein | - |
| STYK_RS09055 (STYK_17390) | - | 1820564..1822741 (+) | 2178 | WP_000804748.1 | CD3337/EF1877 family mobilome membrane protein | - |
| STYK_RS09060 (STYK_17400) | - | 1822738..1823739 (+) | 1002 | WP_261804925.1 | lysozyme family protein | - |
| STYK_RS09065 (STYK_17410) | - | 1823736..1824668 (+) | 933 | WP_001224318.1 | conjugal transfer protein | - |
| STYK_RS10285 | - | 1824982..1825029 (+) | 48 | Protein_1738 | hypothetical protein | - |
| STYK_RS09075 (STYK_17420) | tet(M) | 1825045..1826964 (+) | 1920 | WP_261804926.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| STYK_RS09080 | - | 1827083..1827250 (+) | 168 | WP_000336323.1 | cysteine-rich KTR domain-containing protein | - |
| STYK_RS09085 | - | 1827310..1827447 (-) | 138 | Protein_1741 | XRE family transcriptional regulator | - |
| STYK_RS09090 | - | 1827681..1827764 (+) | 84 | WP_001865637.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
| STYK_RS09095 (STYK_17430) | erm(B) | 1827889..1828626 (+) | 738 | WP_001038790.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| STYK_RS09100 (STYK_17440) | - | 1828981..1829535 (+) | 555 | WP_000576156.1 | recombinase family protein | - |
| STYK_RS09105 (STYK_17450) | - | 1829539..1832457 (+) | 2919 | WP_001240982.1 | Tn3 family transposase | - |
| STYK_RS09110 (STYK_17460) | - | 1832531..1832752 (-) | 222 | Protein_1746 | helix-turn-helix domain-containing protein | - |
| STYK_RS09115 (STYK_17470) | - | 1833257..1833679 (+) | 423 | WP_000804885.1 | sigma-70 family RNA polymerase sigma factor | - |
| STYK_RS09120 (STYK_17480) | - | 1833676..1833906 (+) | 231 | WP_000857133.1 | helix-turn-helix domain-containing protein | - |
| STYK_RS09125 | - | 1834132..1834383 (-) | 252 | WP_001845478.1 | hypothetical protein | - |
| STYK_RS09130 (STYK_17490) | - | 1834367..1834570 (+) | 204 | WP_061825251.1 | excisionase | - |
| STYK_RS09135 (STYK_17500) | - | 1834652..1835869 (+) | 1218 | WP_001291561.1 | tyrosine-type recombinase/integrase | - |
| STYK_RS09140 (STYK_17510) | - | 1836130..1837410 (+) | 1281 | WP_261019961.1 | M protein trans-acting positive regulator PRD domain-containing protein | - |
| STYK_RS09145 (STYK_17520) | - | 1837525..1841421 (+) | 3897 | WP_261804927.1 | pullulanase | - |
| STYK_RS09150 (STYK_17530) | - | 1841497..1842261 (-) | 765 | WP_261804928.1 | amino acid ABC transporter ATP-binding protein | - |
| STYK_RS09155 (STYK_17540) | - | 1842271..1842993 (-) | 723 | WP_261804929.1 | amino acid ABC transporter permease | - |
| STYK_RS09160 (STYK_17550) | - | 1842997..1843689 (-) | 693 | WP_261804930.1 | amino acid ABC transporter permease | - |
| STYK_RS09165 (STYK_17560) | - | 1843723..1844601 (-) | 879 | WP_084947837.1 | transporter substrate-binding domain-containing protein | - |
| STYK_RS09170 (STYK_17570) | - | 1844613..1845611 (-) | 999 | WP_261804931.1 | uroporphyrinogen decarboxylase family protein | - |
| STYK_RS09175 (STYK_17580) | - | 1845614..1845817 (-) | 204 | WP_049501818.1 | hypothetical protein | - |
| STYK_RS09180 (STYK_17590) | - | 1845827..1846834 (-) | 1008 | WP_080976372.1 | uroporphyrinogen decarboxylase family protein | - |
| STYK_RS09185 (STYK_17600) | - | 1847054..1848103 (-) | 1050 | WP_261804932.1 | LLM class flavin-dependent oxidoreductase | - |
| STYK_RS09190 | - | 1848160..1848282 (+) | 123 | WP_153300023.1 | chlorohydrolase | - |
| STYK_RS09195 (STYK_17610) | - | 1848311..1849447 (-) | 1137 | WP_000682963.1 | mannitol-1-phosphate 5-dehydrogenase | - |
| STYK_RS09200 (STYK_17620) | - | 1849509..1849946 (-) | 438 | WP_000764147.1 | PTS sugar transporter subunit IIA | - |
| STYK_RS09205 (STYK_17630) | - | 1849948..1851903 (-) | 1956 | WP_014017193.1 | BglG family transcription antiterminator | - |
| STYK_RS09210 (STYK_17640) | - | 1851927..1853696 (-) | 1770 | WP_023939117.1 | PTS mannitol-specific transporter subunit IIBC | - |
| STYK_RS09215 (STYK_17650) | glmS | 1854141..1855949 (-) | 1809 | WP_000334290.1 | glutamine--fructose-6-phosphate transaminase (isomerizing) | - |
| STYK_RS09220 (STYK_17660) | bglA | 1856141..1857520 (-) | 1380 | WP_261804933.1 | 6-phospho-beta-glucosidase | - |
| STYK_RS09225 (STYK_17670) | - | 1857619..1859472 (-) | 1854 | WP_261804934.1 | proline--tRNA ligase | - |
| STYK_RS09230 (STYK_17680) | eeP | 1859485..1860744 (-) | 1260 | WP_261804935.1 | RIP metalloprotease RseP | Regulator |
| STYK_RS09235 (STYK_17690) | - | 1860766..1861569 (-) | 804 | WP_000189868.1 | phosphatidate cytidylyltransferase | - |
| STYK_RS09240 (STYK_17700) | - | 1861578..1862336 (-) | 759 | WP_000467312.1 | isoprenyl transferase | - |
Sequence
Protein
Download Length: 209 a.a. Molecular weight: 23924.04 Da Isoelectric Point: 9.2991
>NTDB_id=85769 STYK_RS08980 WP_004239116.1 1799640..1800269(-) (comM) [Streptococcus toyakuensis strain TP1632]
MEKMKKQIRVLLLLTVFGLSSCSCLSLSTWALMLNQNCFYYLVGMLLLASIGAGLNYYRGQGNQHYSVFKEDKQQFLYSL
LLLVNILGLALIVIEHILAGNTSVEGFVEAFLPSFFFLFGIDLLVFLPIQKYVNGVKKFLGKKEICFISGLAILIFLRNP
WMLLSMTFYIALGMLFLGLLVPKVIRWEVSFYSHLMRDILLVVFLLFLF
MEKMKKQIRVLLLLTVFGLSSCSCLSLSTWALMLNQNCFYYLVGMLLLASIGAGLNYYRGQGNQHYSVFKEDKQQFLYSL
LLLVNILGLALIVIEHILAGNTSVEGFVEAFLPSFFFLFGIDLLVFLPIQKYVNGVKKFLGKKEICFISGLAILIFLRNP
WMLLSMTFYIALGMLFLGLLVPKVIRWEVSFYSHLMRDILLVVFLLFLF
Nucleotide
Download Length: 630 bp
>NTDB_id=85769 STYK_RS08980 WP_004239116.1 1799640..1800269(-) (comM) [Streptococcus toyakuensis strain TP1632]
ATGGAAAAAATGAAAAAGCAAATTCGAGTTTTGTTATTGCTGACAGTTTTTGGTCTTAGCAGCTGTTCTTGTTTAAGTTT
ATCTACTTGGGCCTTGATGTTAAATCAAAACTGCTTCTATTATTTAGTTGGCATGTTGCTTCTTGCCAGTATTGGTGCAG
GGCTAAACTATTATAGAGGGCAGGGAAATCAACATTATTCAGTTTTTAAGGAAGATAAGCAACAATTCTTGTATAGTCTC
TTGCTCTTAGTAAATATTTTGGGTTTAGCTTTAATTGTCATAGAACATATCCTTGCAGGAAATACATCCGTAGAAGGATT
TGTGGAAGCCTTTCTACCGAGTTTCTTTTTCTTATTTGGGATTGATTTGTTAGTTTTTCTGCCGATTCAGAAGTATGTAA
ATGGAGTGAAAAAGTTTTTGGGAAAGAAGGAAATCTGTTTTATTAGTGGACTAGCTATTCTAATCTTTCTCAGAAATCCT
TGGATGCTATTGTCCATGACCTTTTATATTGCCTTGGGGATGCTATTTCTAGGACTGTTGGTGCCAAAAGTCATTCGCTG
GGAAGTTTCATTTTACAGTCATTTGATGAGAGATATCTTGTTAGTTGTCTTCTTGCTGTTTCTATTTTAA
ATGGAAAAAATGAAAAAGCAAATTCGAGTTTTGTTATTGCTGACAGTTTTTGGTCTTAGCAGCTGTTCTTGTTTAAGTTT
ATCTACTTGGGCCTTGATGTTAAATCAAAACTGCTTCTATTATTTAGTTGGCATGTTGCTTCTTGCCAGTATTGGTGCAG
GGCTAAACTATTATAGAGGGCAGGGAAATCAACATTATTCAGTTTTTAAGGAAGATAAGCAACAATTCTTGTATAGTCTC
TTGCTCTTAGTAAATATTTTGGGTTTAGCTTTAATTGTCATAGAACATATCCTTGCAGGAAATACATCCGTAGAAGGATT
TGTGGAAGCCTTTCTACCGAGTTTCTTTTTCTTATTTGGGATTGATTTGTTAGTTTTTCTGCCGATTCAGAAGTATGTAA
ATGGAGTGAAAAAGTTTTTGGGAAAGAAGGAAATCTGTTTTATTAGTGGACTAGCTATTCTAATCTTTCTCAGAAATCCT
TGGATGCTATTGTCCATGACCTTTTATATTGCCTTGGGGATGCTATTTCTAGGACTGTTGGTGCCAAAAGTCATTCGCTG
GGAAGTTTCATTTTACAGTCATTTGATGAGAGATATCTTGTTAGTTGTCTTCTTGCTGTTTCTATTTTAA
Domains
No domain identified.
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comM | Streptococcus mitis NCTC 12261 |
100 |
100 |
1 |
| comM | Streptococcus mitis SK321 |
92.965 |
95.215 |
0.885 |
| comM | Streptococcus pneumoniae D39 |
39.024 |
98.086 |
0.383 |
| comM | Streptococcus pneumoniae R6 |
39.024 |
98.086 |
0.383 |
| comM | Streptococcus pneumoniae TIGR4 |
39.024 |
98.086 |
0.383 |