Detailed information NTG0844902

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QQ988_RS04580
• Genome accession: NZ_CP127869
• Coordinates: 967699..968745 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain NG02
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 962699..973745

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QQ988_RS04555 (QQ988_04555)	-	963840..964376 (+)	537	WP_002494124.1	hypothetical protein	-
QQ988_RS04560 (QQ988_04560)	-	964527..965513 (-)	987	WP_002494125.1	aromatic acid exporter family protein	-
QQ988_RS04565 (QQ988_04565)	map	965687..966442 (+)	756	WP_193620699.1	type I methionyl aminopeptidase	-
QQ988_RS04570 (QQ988_04570)	-	966600..966986 (+)	387	WP_001830382.1	hypothetical protein	-
QQ988_RS04575 (QQ988_04575)	liaF	967001..967702 (+)	702	WP_286097108.1	cell wall-active antibiotics response protein LiaF	-
QQ988_RS04580 (QQ988_04580)	vraS	967699..968745 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
QQ988_RS04585 (QQ988_04585)	vraR	968735..969364 (+)	630	WP_002473914.1	two-component system response regulator VraR	Regulator
QQ988_RS04590 (QQ988_04590)	-	969421..970599 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
QQ988_RS04595 (QQ988_04595)	-	971006..971290 (-)	285	WP_002473916.1	YtxH domain-containing protein	-
QQ988_RS04600 (QQ988_04600)	-	971298..971762 (-)	465	WP_002498659.1	low molecular weight protein-tyrosine-phosphatase	-
QQ988_RS04605 (QQ988_04605)	-	971903..972118 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
QQ988_RS04610 (QQ988_04610)	-	972120..973361 (+)	1242	WP_017465013.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=844902 QQ988_RS04580 WP_001830374.1 967699..968745(+) (vraS) [Staphylococcus epidermidis strain NG02]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=844902 QQ988_RS04580 WP_001830374.1 967699..968745(+) (vraS) [Staphylococcus epidermidis strain NG02]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACGGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ACATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCTAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCAGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTGTTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCATTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGCGACA
TTCAAATGGTACAAAAGTAACTGTAGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92