Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   VKP53_RS02740 Genome accession   NZ_CP142354
Coordinates   532283..532924 (+) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain 6745-99     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 527283..537924
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP53_RS02720 (VKP53_02720) - 527839..528579 (+) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  VKP53_RS02725 (VKP53_02725) pknB 528576..530474 (+) 1899 WP_002994648.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  VKP53_RS02730 (VKP53_02730) liaF 530597..531289 (+) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  VKP53_RS02735 (VKP53_02735) - 531286..532290 (+) 1005 WP_002991890.1 sensor histidine kinase -
  VKP53_RS02740 (VKP53_02740) vraR 532283..532924 (+) 642 WP_002983671.1 response regulator transcription factor Regulator
  VKP53_RS02745 (VKP53_02745) - 532961..534361 (+) 1401 WP_115230438.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  VKP53_RS02750 (VKP53_02750) - 534361..534738 (+) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  VKP53_RS02755 (VKP53_02755) cysK 534756..535697 (-) 942 WP_011888673.1 cysteine synthase A -
  VKP53_RS02760 (VKP53_02760) - 535825..536457 (-) 633 WP_009880468.1 YigZ family protein -
  VKP53_RS02765 (VKP53_02765) comFA/cflA 536513..537838 (+) 1326 WP_326675006.1 DEAD/DEAH box helicase Machinery gene

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=840501 VKP53_RS02740 WP_002983671.1 532283..532924(+) (vraR) [Streptococcus pyogenes strain 6745-99]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=840501 VKP53_RS02740 WP_002983671.1 532283..532924(+) (vraR) [Streptococcus pyogenes strain 6745-99]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGTGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385