Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   VKP56_RS06570 Genome accession   NZ_CP142350
Coordinates   1294161..1294802 (-) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain SS1445     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1289161..1299802
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP56_RS06545 (VKP56_06545) - 1289246..1290572 (-) 1327 Protein_1240 DEAD/DEAH box helicase -
  VKP56_RS06550 (VKP56_06550) - 1290628..1291260 (+) 633 WP_009880468.1 YigZ family protein -
  VKP56_RS06555 (VKP56_06555) cysK 1291388..1292329 (+) 942 WP_011888673.1 cysteine synthase A -
  VKP56_RS06560 (VKP56_06560) - 1292347..1292724 (-) 378 WP_002983674.1 S1 RNA-binding domain-containing protein -
  VKP56_RS06565 (VKP56_06565) - 1292724..1294124 (-) 1401 WP_136274203.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  VKP56_RS06570 (VKP56_06570) vraR 1294161..1294802 (-) 642 WP_002983671.1 response regulator transcription factor Regulator
  VKP56_RS06575 (VKP56_06575) - 1294795..1295799 (-) 1005 WP_002991890.1 sensor histidine kinase -
  VKP56_RS06580 (VKP56_06580) liaF 1295796..1296488 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  VKP56_RS06585 (VKP56_06585) pknB 1296611..1298509 (-) 1899 WP_012560855.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  VKP56_RS06590 (VKP56_06590) - 1298506..1299246 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=840143 VKP56_RS06570 WP_002983671.1 1294161..1294802(-) (vraR) [Streptococcus pyogenes strain SS1445]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=840143 VKP56_RS06570 WP_002983671.1 1294161..1294802(-) (vraR) [Streptococcus pyogenes strain SS1445]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCCATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385