Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   VKP35_RS08995 Genome accession   NZ_CP142349
Coordinates   1760400..1762382 (-) Length   660 a.a.
NCBI ID   WP_011018317.1    Uniprot ID   Q8NZ25
Organism   Streptococcus pyogenes strain 11RS100     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1755400..1767382
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP35_RS08970 (VKP35_08970) recA 1755436..1756572 (-) 1137 WP_326622828.1 recombinase RecA Machinery gene
  VKP35_RS08975 (VKP35_08975) cinA 1756661..1757932 (-) 1272 WP_111713422.1 competence/damage-inducible protein A Machinery gene
  VKP35_RS08980 (VKP35_08980) - 1758001..1758561 (-) 561 WP_023611248.1 DNA-3-methyladenine glycosylase I -
  VKP35_RS08985 (VKP35_08985) ruvA 1758571..1759167 (-) 597 WP_002982180.1 Holliday junction branch migration protein RuvA Machinery gene
  VKP35_RS08990 (VKP35_08990) - 1759169..1760389 (-) 1221 WP_002982178.1 MDR family MFS transporter -
  VKP35_RS08995 (VKP35_08995) hexB 1760400..1762382 (-) 1983 WP_011018317.1 DNA mismatch repair endonuclease MutL Machinery gene
  VKP35_RS09000 (VKP35_09000) - 1762477..1763622 (-) 1146 WP_021775554.1 tyrosine-type recombinase/integrase -
  VKP35_RS09005 (VKP35_09005) - 1764255..1765082 (-) 828 WP_014411910.1 hypothetical protein -
  VKP35_RS09010 (VKP35_09010) - 1765114..1765263 (+) 150 WP_154079230.1 hypothetical protein -
  VKP35_RS09015 (VKP35_09015) - 1765489..1766280 (-) 792 WP_014411911.1 helix-turn-helix domain-containing protein -
  VKP35_RS09020 (VKP35_09020) - 1766435..1766605 (+) 171 WP_032467166.1 helix-turn-helix transcriptional regulator -
  VKP35_RS09025 (VKP35_09025) - 1766660..1767067 (+) 408 WP_011185070.1 hypothetical protein -

Sequence

Protein


Download         Length: 660 a.a.        Molecular weight: 74418.02 Da        Isoelectric Point: 5.7605

>NTDB_id=840075 VKP35_RS08995 WP_011018317.1 1760400..1762382(-) (hexB) [Streptococcus pyogenes strain 11RS100]
MTNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVTDNGEGMSHEDLPLSLRRHATSK
IKSQSDLFRIRTLGFRGEALPSVASISKITIKTATKEVTHGSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLVISNADLDFEVSGYVSLP
ELTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDIQIDPYLADVNVHPTKQEVRISKERELMALIST
AISESLKEQDLIPDALENLAKSSTRHFSKPEQTQLPLQSRGLYYDPQKNDFFVKESAVSEKIPETDFYFGAVDNSVKVEK
AELLPHSEEVIGPSSVKHASRPQNTFTETDHPNLDLKNRQKLSQMLTRLENEEQSVFPELDYFGQMHGTYLFAQGKDGLF
IIDQHAAQERVKYEYYRDKIGEVDSSLQQLLVPYLFEFSGSDFINLQEKMALLNEVGIFLEVYGHNTFILREHPIWMKEE
EIASGVYEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKANHSLDDYSARNLLLQLAQCQNPYNCPHGRPVLINFSKADM
EKMFRRIQENHTSLRELGKY

Nucleotide


Download         Length: 1983 bp        

>NTDB_id=840075 VKP35_RS08995 WP_011018317.1 1760400..1762382(-) (hexB) [Streptococcus pyogenes strain 11RS100]
ATGACAAACATTATTGAATTACCGGAAGTTCTCGCCAACCAAATTGCAGCTGGTGAAGTTGTAGAAAGGCCAGCGAGTGT
TGTAAAGGAATTGGTTGAGAATGCTATTGATGCTAAAAGTAGCCAGATTACCGTTGAAATTGAAGAGTCTGGCCTTAAGA
TGATACAGGTTACAGACAACGGTGAGGGAATGTCTCATGAAGATTTACCTTTAAGTCTGCGTCGCCACGCTACTAGTAAA
ATTAAGAGTCAGAGTGATTTGTTTAGAATTAGAACACTTGGCTTCCGTGGAGAGGCTTTACCGTCTGTTGCCTCTATCAG
TAAAATCACGATAAAAACAGCAACAAAAGAAGTCACTCACGGTTCTCTTCTTATAGCTACTGGTGGGGAAATTGAGACAC
TTGAAGCGATCTCAACTCCTACTGGAACCAAAATTAAGGTTGAAAACCTTTTTTACAACACGCCTGCTCGTCTCAAATAC
ATGAAAAGTTTACAGGCAGAATTAGCTCACATTGTAGATGTGGTCAACCGGTTGAGTTTGGCACATCCAGAAGTTGCTTT
CACACTGATTAGTGATGGTCGCCAATTAACTCAGACATCAGGAACTGGCGATTTACGCCAAGCAATTGCAGGGATTTATG
GTTTGAATACTACCAAAAAAATGCTGGTTATCTCTAATGCTGATTTGGATTTTGAAGTTTCCGGCTATGTTAGCTTGCCA
GAGTTGACACGCGCCAACCGTAATTACATGACGATTTTGGTTAATGGGCGTTACATCAAGAATTTCTTGCTTAATCGAGC
AATTCTTGATGGTTACGGTTCTAAGCTCATGGTTGGACGTTTCCCAATTGTTGTGATTGATATTCAGATTGATCCCTATT
TGGCCGATGTCAATGTTCATCCCACAAAACAAGAGGTTCGTATTTCAAAAGAGCGTGAGTTGATGGCTTTAATTAGTACG
GCGATTTCTGAAAGTCTTAAGGAACAAGATTTGATTCCAGATGCTCTGGAAAACTTAGCCAAATCAAGCACACGACATTT
CTCTAAACCAGAGCAAACACAACTTCCTTTACAGTCTAGGGGACTTTATTATGATCCTCAAAAGAATGACTTTTTTGTCA
AAGAGTCGGCTGTCTCGGAAAAAATACCTGAAACTGATTTTTATTTCGGCGCTGTTGACAACAGTGTAAAGGTTGAAAAA
GCAGAGCTGTTACCCCACTCAGAAGAAGTTATAGGACCTTCTTCGGTTAAACACGCAAGTCGTCCCCAGAATACCTTTAC
CGAGACTGATCATCCTAATCTTGACTTAAAAAACAGACAAAAGTTATCTCAAATGCTAACCCGTTTGGAAAATGAAGAGC
AATCAGTATTTCCTGAATTGGATTATTTTGGTCAGATGCATGGGACTTATCTCTTTGCTCAAGGTAAAGATGGCTTATTT
ATTATCGATCAGCATGCTGCTCAAGAGCGGGTTAAATACGAATATTATCGTGATAAGATTGGTGAGGTTGACAGTAGTTT
ACAGCAGCTATTGGTACCCTATTTGTTTGAGTTTTCTGGTTCTGATTTCATTAACTTACAGGAGAAAATGGCACTCTTAA
ATGAAGTTGGTATCTTCTTAGAAGTTTATGGGCACAATACTTTCATTTTGAGGGAGCATCCTATCTGGATGAAAGAAGAA
GAGATTGCATCTGGTGTCTATGAAATGTGTGACATGTTACTTCTAACCAATGAGGTGTCTATTAAAACTTACCGAGCAGA
GTTAGCTATTATGATGAGTTGTAAACGATCTATCAAGGCAAATCATAGCTTGGATGATTATTCAGCAAGAAATCTGCTAC
TGCAATTGGCCCAATGTCAAAATCCTTATAACTGCCCTCATGGTAGACCCGTATTGATTAATTTTAGTAAGGCAGATATG
GAAAAAATGTTCCGTCGTATCCAAGAAAATCACACTAGCCTGCGAGAGCTAGGAAAATATTAG

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-118)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

MutL C terminal dimerisation domain (MutL_C)

(462-604)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8NZ25

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

67.018

100

0.674