Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   VKP35_RS02680 Genome accession   NZ_CP142349
Coordinates   519950..520591 (+) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain 11RS100     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 514950..525591
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP35_RS02660 (VKP35_02660) - 515506..516246 (+) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  VKP35_RS02665 (VKP35_02665) pknB 516243..518141 (+) 1899 WP_011018054.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  VKP35_RS02670 (VKP35_02670) liaF 518264..518956 (+) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  VKP35_RS02675 (VKP35_02675) - 518953..519957 (+) 1005 WP_002983669.1 sensor histidine kinase -
  VKP35_RS02680 (VKP35_02680) vraR 519950..520591 (+) 642 WP_002983671.1 response regulator transcription factor Regulator
  VKP35_RS02685 (VKP35_02685) - 520628..522028 (+) 1401 WP_002983672.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  VKP35_RS02690 (VKP35_02690) - 522028..522405 (+) 378 WP_002983674.1 S1 RNA-binding domain-containing protein -
  VKP35_RS02695 (VKP35_02695) cysK 522423..523364 (-) 942 WP_002983675.1 cysteine synthase A -
  VKP35_RS02700 (VKP35_02700) - 523492..524124 (-) 633 WP_002983676.1 YigZ family protein -
  VKP35_RS02705 (VKP35_02705) comFA/cflA 524179..525504 (+) 1326 WP_326623183.1 DEAD/DEAH box helicase Machinery gene

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=840025 VKP35_RS02680 WP_002983671.1 519950..520591(+) (vraR) [Streptococcus pyogenes strain 11RS100]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=840025 VKP35_RS02680 WP_002983671.1 519950..520591(+) (vraR) [Streptococcus pyogenes strain 11RS100]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAAGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCCTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCTGGTGCTAAAGGTTACATGTTAAAGAC
TTCTAGTGCAGCCGAAATTCTAAATGCTATTCGGAAAGTTTCAAAAGGTGAATTGGCCATTGAAACAGAGGTGGACAAAA
AAATTAAAGCGCATGACCAACACCCTGATTTGCATGAAGAGCTAACCGCGCGCGAGTATGATATTTTACATCTTTTAGCT
AAAGGGTATGATAATCAAACTATAGCGGATGAACTTTTCATCTCCTTGAAAACCGTTAAAACGCATGTATCTAATATTCT
TGCTAAGCTAGAAGTTGATGACCGAACTCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385