Detailed information NTG0838728

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: LLUL007_RS04620
• Genome accession: NZ_CP126569
• Coordinates: 888621..889313 (+)
• Length: 230 a.a.
• NCBI ID: WP_011676631.1
• Uniprot ID: A0A0M2ZTN8
• Organism: Lactococcus cremoris strain UL007
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 883621..894313

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLUL007_RS04590 (LLUL007_04575)	arsC	884277..884681 (+)	405	WP_011676637.1	arsenate reductase (thioredoxin)	-
LLUL007_RS04595 (LLUL007_04580)	-	884793..885629 (+)	837	WP_011834858.1	metallophosphoesterase	-
LLUL007_RS04600 (LLUL007_04585)	-	885722..886633 (+)	912	WP_396426218.1	CHAP domain-containing protein	-
LLUL007_RS04605 (LLUL007_04590)	-	886870..887232 (+)	363	WP_011834859.1	TIGR02328 family protein	-
LLUL007_RS04610 (LLUL007_04595)	-	887556..887801 (+)	246	WP_011676633.1	type B 50S ribosomal protein L31	-
LLUL007_RS04615 (LLUL007_04600)	-	887934..888464 (+)	531	WP_011834860.1	DUF177 domain-containing protein	-
LLUL007_RS04620 (LLUL007_04605)	covR	888621..889313 (+)	693	WP_011676631.1	response regulator transcription factor	Regulator
LLUL007_RS04625 (LLUL007_04610)	covS	889326..890798 (+)	1473	WP_396426219.1	ATP-binding protein	Regulator
LLUL007_RS04630 (LLUL007_04615)	-	890984..892225 (+)	1242	WP_396426220.1	ammonium transporter	-
LLUL007_RS04635 (LLUL007_04620)	-	892307..892648 (+)	342	WP_282670752.1	P-II family nitrogen regulator	-
LLUL007_RS04640 (LLUL007_04625)	murD	892817..894166 (+)	1350	WP_011834864.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26654.33 Da
• Isoelectric Point: 5.1273

>NTDB_id=838728 LLUL007_RS04620 WP_011676631.1 888621..889313(+) (covR) [Lactococcus cremoris strain UL007]
MASKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=838728 LLUL007_RS04620 WP_011676631.1 888621..889313(+) (covR) [Lactococcus cremoris strain UL007]
ATGGCATCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCTCGTTTCGTCTCATTAGAATTAGAGCATGAAGG
CTATGCCACTGAGATTAAAGATAACGGACGTTCTGGGCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGATGGTTTTGAAGTTGCCCGCCGTTTGCGCAAAGAAAAAGATACTCCAATTATTATGATG
ACCGCGCGTGATTCAACAATGGACCGTGTTGCTGGTCTTGATATTGGAGCAGATGATTATATTACTAAGCCTTTTGCGAT
TGAAGAACTTTTGGCTCGTGTTCGTGCATTCTTCCGTCGTGAAGAACATGGTCATGCTGTAGAACGTGCTGAAAACACTT
CTTTTCGTGATCTTGTAATTGACAAAACAAATCGTACCGTTCACCGCGGTAAAAAAGTAATTGATTTGACGCGTCGTGAA
TACGATCTTCTTTTGACGTTGATGCAAAATGTTGGGGATGTTGTCACTCGCGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACGGAAACAAATGTTGTTGATGTATATATCCGCTATCTTAGAAATAAAATTGATGTTGAAGGACAAGACA
GCTATATTCAAACCGTTCGTGGTTTGGGTTATGTGATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: A0A0M2ZTN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.565	100	0.996
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361