Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   U2W45_RS06750 Genome accession   NZ_CP140117
Coordinates   1321546..1322187 (-) Length   213 a.a.
NCBI ID   WP_010922536.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NV1     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1316546..1327187
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U2W45_RS06725 (U2W45_06720) comFA/cflA 1316632..1317957 (-) 1326 WP_010922534.1 DEAD/DEAH box helicase Machinery gene
  U2W45_RS06730 (U2W45_06725) - 1318013..1318645 (+) 633 WP_009880468.1 YigZ family protein -
  U2W45_RS06735 (U2W45_06730) cysK 1318773..1319714 (+) 942 WP_010922535.1 cysteine synthase A -
  U2W45_RS06740 (U2W45_06735) - 1319732..1320109 (-) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  U2W45_RS06745 (U2W45_06740) - 1320109..1321509 (-) 1401 WP_011285657.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  U2W45_RS06750 (U2W45_06745) vraR 1321546..1322187 (-) 642 WP_010922536.1 response regulator transcription factor Regulator
  U2W45_RS06755 (U2W45_06750) - 1322180..1323184 (-) 1005 WP_002991890.1 sensor histidine kinase -
  U2W45_RS06760 (U2W45_06755) liaF 1323181..1323873 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  U2W45_RS06765 (U2W45_06760) pknB 1323996..1325894 (-) 1899 WP_010922538.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  U2W45_RS06770 (U2W45_06765) - 1325891..1326631 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23693.40 Da        Isoelectric Point: 5.3506

>NTDB_id=833639 U2W45_RS06750 WP_010922536.1 1321546..1322187(-) (vraR) [Streptococcus pyogenes strain NV1]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVGDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=833639 U2W45_RS06750 WP_010922536.1 1321546..1322187(-) (vraR) [Streptococcus pyogenes strain NV1]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGACATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGGTGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACATCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(148-202)

Response regulator receiver domain (Response_reg)

(6-118)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385