Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   R8635_RS09235 Genome accession   NZ_AP026924
Coordinates   1789325..1789957 (-) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain PZ900700063     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1784325..1794957
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8635_RS09205 (PC0062_18320) tig 1785358..1786641 (-) 1284 WP_044811780.1 trigger factor -
  R8635_RS09210 (PC0062_18330) - 1786802..1787140 (-) 339 WP_001812733.1 tyrosine-type recombinase/integrase -
  R8635_RS09215 (PC0062_18340) cbpG 1787496..1788086 (-) 591 Protein_1832 choline-binding protein CbpG -
  R8635_RS09220 (PC0062_18350) - 1788167..1788406 (-) 240 WP_000754501.1 hypothetical protein -
  R8635_RS09225 - 1788556..1789324 (-) 769 Protein_1834 DNA alkylation repair protein -
  R8635_RS09235 (PC0062_18380) vraR 1789325..1789957 (-) 633 WP_000698434.1 response regulator transcription factor Regulator
  R8635_RS09240 (PC0062_18390) - 1789971..1790966 (-) 996 WP_000743672.1 sensor histidine kinase -
  R8635_RS09245 (PC0062_18400) liaF 1790963..1791661 (-) 699 WP_268217904.1 cell wall-active antibiotics response protein LiaF -
  R8635_RS09250 (PC0062_18410) fni 1791738..1792748 (-) 1011 WP_000210617.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  R8635_RS09255 (PC0062_18420) - 1792732..1793739 (-) 1008 WP_000562441.1 phosphomevalonate kinase -
  R8635_RS09260 (PC0062_18430) mvaD 1793726..1794679 (-) 954 WP_000373457.1 diphosphomevalonate decarboxylase -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=82583 R8635_RS09235 WP_000698434.1 1789325..1789957(-) (vraR) [Streptococcus pneumoniae strain PZ900700063]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=82583 R8635_RS09235 WP_000698434.1 1789325..1789957(-) (vraR) [Streptococcus pneumoniae strain PZ900700063]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGATTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41