Detailed information NTG0823261

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: R6I05_RS14485
• Genome accession: NZ_CP137705
• Coordinates: 2979118..2981394 (-)
• Length: 758 a.a.
• NCBI ID: WP_000934041.1
• Uniprot ID: P0ABI0
• Organism: Escherichia coli isolate FELIX_MS724
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 2974118..2986394

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R6I05_RS14465 (R6I05_14465)	cydC	2975463..2977184 (+)	1722	WP_256692609.1	heme ABC transporter ATP-binding protein/permease CydC	-
R6I05_RS14470 (R6I05_14470)	aat	2977226..2977930 (+)	705	WP_001241678.1	leucyl/phenylalanyl-tRNA--protein transferase	-
R6I05_RS14475 (R6I05_14475)	infA	2978215..2978433 (+)	219	WP_001040187.1	translation initiation factor IF-1	-
R6I05_RS14485 (R6I05_14485)	clpC	2979118..2981394 (-)	2277	WP_000934041.1	ATP-dependent Clp protease ATP-binding subunit ClpA	Regulator
R6I05_RS14490 (R6I05_14490)	clpS	2981425..2981745 (-)	321	WP_000520781.1	ATP-dependent Clp protease adapter ClpS	-
R6I05_RS14495 (R6I05_14495)	-	2982382..2982663 (-)	282	WP_001504099.1	hypothetical protein	-
R6I05_RS14500 (R6I05_14500)	-	2982666..2983151 (-)	486	WP_000373415.1	DUF1441 family protein	-
R6I05_RS14505 (R6I05_14505)	-	2983409..2985322 (-)	1914	WP_074514890.1	ClpP-like prohead protease/major capsid protein fusion protein	-
R6I05_RS14510 (R6I05_14510)	-	2985952..2986374 (-)	423	WP_000126661.1	single-stranded DNA-binding protein	-

Sequence

Protein

• Length: 758 a.a.
• Molecular weight: 84206.93 Da
• Isoelectric Point: 6.2512

>NTDB_id=823261 R6I05_RS14485 WP_000934041.1 2979118..2981394(-) (clpC) [Escherichia coli isolate FELIX_MS724]
MLNQELELSLNMAFARAREHRHEFMTVEHLLLALLSNPSAREALEACSVDLVALRQELEAFIEQTTPVLPASEEERDTQP
TLSFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQAAYLLRKHEVSRLDVVNFISHGTRKDEPTQSSDPGSQPNSE
EQAGGEERMENFTTNLNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGDVPEVM
ADCTIYSLDIGSLLAGTKYRGDFEKRFKALLKQLEQDTNSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRVIG
STTYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAHHDVRYTAKAVRAAVELAVKYINDRHLPDKAID
VIDEAGARARLMPVSKRKKTVNVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAIEALTEAIKMARAG
LGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIKHPHAV
LLLDEIEKAHPDVFNILLQVMDNGTLTDNNGRKADFRNVVLVMTTNAGVRETERKSIGLIHQDNSTDAMEEIKKIFTPEF
RNRLDNIIWFDHLSTDVIHQVVDKFIVELQVQLDQKGVSLEVSQEARNWLAEKGYDRAMGARPMARVIQDNLKKPLANEL
LFGSLVDGGQVTVALDKEKNELTYGFQSAQKHKAEAAH

Nucleotide

• Length: 2277 bp

>NTDB_id=823261 R6I05_RS14485 WP_000934041.1 2979118..2981394(-) (clpC) [Escherichia coli isolate FELIX_MS724]
ATGCTCAATCAAGAACTGGAACTCAGTTTAAATATGGCTTTCGCCAGAGCGCGCGAGCACCGTCATGAGTTTATGACCGT
CGAGCACTTGTTACTGGCGCTGCTCAGTAACCCATCTGCCCGGGAGGCGCTGGAAGCGTGTTCTGTGGATTTGGTTGCGC
TCCGTCAGGAACTGGAAGCCTTTATTGAACAAACCACACCCGTTCTGCCTGCCAGTGAAGAGGAGCGCGACACACAGCCG
ACGCTGAGTTTTCAGCGTGTACTGCAACGTGCGGTCTTCCATGTCCAGTCCTCCGGTCGCAATGAGGTTACCGGTGCAAA
CGTTCTGGTCGCTATCTTTAGCGAACAGGAGTCGCAGGCGGCATATCTGTTGCGTAAACATGAAGTCAGCCGTCTCGATG
TGGTGAACTTTATCTCTCATGGCACGCGTAAAGACGAGCCGACACAGTCTTCTGATCCTGGCAGCCAGCCAAACAGCGAA
GAACAAGCTGGTGGGGAGGAACGTATGGAGAATTTCACGACGAACCTGAATCAGCTTGCGCGCGTGGGCGGAATCGACCC
ACTGATTGGTCGTGAGAAGGAGCTGGAGCGTGCTATTCAGGTTCTCTGCCGTCGCCGTAAAAACAACCCGCTGCTGGTGG
GGGAATCTGGTGTCGGTAAAACCGCGATTGCGGAAGGTCTTGCCTGGCGAATTGTTCAGGGCGATGTGCCGGAAGTGATG
GCTGACTGTACGATTTACTCTCTCGATATCGGTTCTCTGTTAGCGGGCACAAAATATCGCGGCGACTTTGAAAAACGTTT
TAAAGCGTTGCTCAAGCAGCTGGAGCAGGACACTAACAGCATCCTGTTTATTGATGAGATCCACACCATTATCGGTGCGG
GTGCAGCGTCTGGTGGTCAGGTCGATGCGGCTAACCTAATCAAACCGTTGCTCTCCAGCGGTAAAATTCGTGTAATTGGT
TCGACAACCTATCAGGAGTTCAGCAACATTTTCGAGAAAGACCGTGCTCTGGCGCGTCGCTTCCAGAAAATTGATATTAC
TGAACCGTCGATCGAAGAAACTGTTCAAATCATCAATGGCCTGAAACCGAAGTATGAAGCGCACCACGACGTGCGTTATA
CCGCAAAAGCGGTGCGTGCGGCGGTAGAGCTGGCGGTGAAATACATTAACGATCGTCATCTGCCGGATAAAGCCATTGAT
GTTATCGACGAAGCGGGCGCTCGCGCACGCCTGATGCCGGTAAGCAAACGCAAGAAAACCGTTAATGTGGCGGATATTGA
GTCCGTGGTGGCCCGTATTGCACGCATTCCAGAGAAGAGTGTTTCTCAGAGTGATCGTGATACCCTGAAAAACCTCGGCG
ATCGCTTGAAAATGCTGGTCTTCGGTCAGGATAAAGCCATTGAGGCGCTGACTGAAGCCATTAAGATGGCGCGTGCAGGT
TTAGGTCACGAACATAAACCGGTTGGTTCGTTCCTGTTTGCCGGCCCTACCGGGGTCGGGAAAACAGAGGTGACGGTACA
GCTTTCGAAAGCTTTGGGCATTGAGCTTCTGCGCTTTGATATGTCCGAGTATATGGAACGCCATACCGTCAGCCGTCTTA
TTGGTGCGCCTCCGGGATACGTTGGTTTTGATCAGGGCGGTTTGCTGACTGATGCGGTCATCAAGCATCCACATGCGGTG
CTGCTGCTGGACGAAATCGAGAAAGCGCACCCGGACGTGTTCAATATTCTGTTGCAGGTGATGGATAACGGTACGCTGAC
CGATAACAACGGACGCAAAGCAGACTTCCGTAACGTGGTGCTGGTGATGACCACCAACGCCGGGGTACGGGAAACTGAGC
GCAAATCCATTGGTCTTATCCACCAGGATAACAGCACCGATGCGATGGAAGAGATCAAGAAGATCTTTACACCGGAATTC
CGTAACCGTCTCGACAACATTATCTGGTTTGATCATCTGTCAACCGACGTGATCCATCAGGTGGTGGATAAATTCATCGT
CGAGTTGCAGGTTCAGCTGGATCAGAAAGGTGTTTCTCTGGAAGTGAGCCAGGAAGCGCGTAACTGGCTGGCCGAGAAAG
GTTACGACCGGGCAATGGGCGCTCGTCCGATGGCGCGTGTCATCCAGGACAACCTGAAAAAACCGCTCGCCAACGAACTG
CTGTTTGGTTCGCTGGTGGACGGCGGTCAGGTCACCGTCGCGCTGGATAAAGAGAAAAATGAGCTGACTTACGGATTCCA
GAGTGCACAAAAGCACAAGGCGGAAGCAGCGCATTAA

Domains

Predicted by InterProScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (486-647)

• ATPase family associated with various cellular activities (AAA) (AAA) (211-342)

• AAA lid domain (AAA_lid_9) (350-452)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (13-62)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (653-733)

3D structure

• AlphaFold DB: P0ABI0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	38.868	100	0.408
clpA	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	41.346	96.042	0.397
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	35.46	100	0.381
clpC	Streptococcus thermophilus LMD-9	42.37	89.05	0.377
clpC	Streptococcus thermophilus LMG 18311	42.222	89.05	0.376
clpC	Streptococcus mutans UA159	39.407	93.404	0.368