Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   R8586_RS01965 Genome accession   NZ_AP026922
Coordinates   377277..377909 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain PZ900700038     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 372277..382909
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8586_RS01940 (PC0038_03810) mvaD 372554..373507 (+) 954 WP_000373452.1 diphosphomevalonate decarboxylase -
  R8586_RS01945 (PC0038_03820) - 373494..374501 (+) 1008 WP_000562440.1 phosphomevalonate kinase -
  R8586_RS01950 (PC0038_03830) fni 374485..375495 (+) 1011 WP_000210618.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  R8586_RS01955 (PC0038_03840) liaF 375573..376271 (+) 699 WP_001224637.1 cell wall-active antibiotics response protein LiaF -
  R8586_RS01960 (PC0038_03850) - 376268..377263 (+) 996 WP_000743686.1 sensor histidine kinase -
  R8586_RS01965 (PC0038_03860) vraR 377277..377909 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  R8586_RS01970 (PC0038_03870) - 377910..378152 (+) 243 WP_001854757.1 DNA alkylation repair protein -
  R8586_RS01975 - 378134..378676 (+) 543 Protein_387 DNA alkylation repair protein -
  R8586_RS01980 (PC0038_03890) - 378826..379065 (+) 240 WP_000754502.1 hypothetical protein -
  R8586_RS01985 (PC0038_03900) cbpG 379146..379736 (+) 591 Protein_389 choline-binding protein CbpG -
  R8586_RS01990 (PC0038_03910) - 380092..380397 (+) 306 WP_001821501.1 tyrosine-type recombinase/integrase -
  R8586_RS01995 (PC0038_03920) tig 380591..381874 (+) 1284 WP_000116462.1 trigger factor -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=82282 R8586_RS01965 WP_000698434.1 377277..377909(+) (vraR) [Streptococcus pneumoniae strain PZ900700038]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=82282 R8586_RS01965 WP_000698434.1 377277..377909(+) (vraR) [Streptococcus pneumoniae strain PZ900700038]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGTTTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41

Multiple sequence alignment