Detailed information NTG0082094

Bioinformatically predicted

Overview

• Name: braR
• Type: Regulator
• Locus tag: R8566_RS08275
• Genome accession: NZ_AP026920
• Coordinates: 1608740..1609417 (-)
• Length: 225 a.a.
• NCBI ID: WP_000548959.1
• Uniprot ID: Q9S1K2
• Organism: Streptococcus pneumoniae strain PZ900700014
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1603740..1614417

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8566_RS08245 (PC0014_16540)	-	1603903..1604532 (-)	630	WP_000762076.1	NAD(P)-dependent oxidoreductase	-
R8566_RS08250	-	1604770..1604970 (+)	201	WP_001814296.1	hypothetical protein	-
R8566_RS08255 (PC0014_16560)	-	1605400..1605540 (+)	141	WP_000422775.1	MazG-like protein	-
R8566_RS08260 (PC0014_16570)	-	1605547..1605723 (+)	177	WP_000166031.1	MazG-like protein	-
R8566_RS08265 (PC0014_16580)	thrS	1605781..1607724 (+)	1944	WP_000608349.1	threonine--tRNA ligase	-
R8566_RS08270 (PC0014_16590)	-	1607773..1608747 (-)	975	WP_000887953.1	HAMP domain-containing histidine kinase	-
R8566_RS08275 (PC0014_16600)	braR	1608740..1609417 (-)	678	WP_000548959.1	response regulator transcription factor	Regulator
R8566_RS08280 (PC0014_16610)	-	1609573..1610646 (+)	1074	WP_001273823.1	DUF2974 domain-containing protein	-
R8566_RS08285 (PC0014_16620)	-	1610737..1611039 (-)	303	WP_000281609.1	hypothetical protein	-
R8566_RS08290 (PC0014_16630)	-	1611107..1611544 (-)	438	WP_001166786.1	Rrf2 family transcriptional regulator	-
R8566_RS08295 (PC0014_16640)	-	1611620..1612462 (-)	843	WP_000160938.1	metallophosphoesterase	-
R8566_RS08300 (PC0014_16650)	-	1612574..1613224 (+)	651	WP_000188505.1	metal-dependent transcriptional regulator	-
R8566_RS08305 (PC0014_16660)	-	1613421..1614096 (+)	676	Protein_1638	nicotinamide mononucleotide transporter	-
R8566_RS11525	-	1614198..1614269 (+)	72	Protein_1639	glutamine ABC transporter permease	-

Sequence

Protein

• Length: 225 a.a.
• Molecular weight: 25964.16 Da
• Isoelectric Point: 5.1362

>NTDB_id=82094 R8566_RS08275 WP_000548959.1 1608740..1609417(-) (braR) [Streptococcus pneumoniae strain PZ900700014]
MHKILLIEDDQVIRQQIGKMLSEWGFEVVLVEDFMEVLSLFVQSEPHLVLMDIGLPLFNGYHWCQEIRKISKVPIMFLSS
RDQAMDIVMAINMGADDFVTKPFDQQVLLAKVQGLLRRSYEFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQIL
RVLFEHAGNIVARDDLMRELWNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGIGYGLKHA

Nucleotide

• Length: 678 bp

>NTDB_id=82094 R8566_RS08275 WP_000548959.1 1608740..1609417(-) (braR) [Streptococcus pneumoniae strain PZ900700014]
ATGCACAAGATTTTATTAATAGAAGATGATCAGGTCATTCGTCAACAGATTGGGAAAATGCTCTCTGAATGGGGATTTGA
AGTGGTCCTGGTAGAAGACTTTATGGAAGTTTTGAGTCTATTTGTTCAGTCGGAACCTCATCTGGTCCTCATGGATATTG
GTTTGCCCTTGTTTAATGGTTATCACTGGTGTCAGGAAATCCGCAAGATTTCCAAGGTACCTATCATGTTTCTTTCTTCG
AGAGACCAGGCTATGGATATTGTCATGGCAATCAATATGGGGGCGGATGACTTTGTGACCAAGCCTTTTGACCAGCAGGT
TCTTTTAGCTAAGGTTCAGGGCTTGTTGCGTCGTTCCTATGAGTTTGGGCGTGATGAGAGTTTGCTGGAATATGCTGGTG
TTATCCTCAATACCAAATCCATGGATTTACATTATCAAGGGCAAGTCTTGAATTTGACCAAGAATGAATTCCAGATTTTA
CGCGTGTTATTTGAGCATGCAGGCAACATCGTAGCACGTGACGACCTGATGCGGGAACTTTGGAACAGTGACTTTTTCAT
TGATGATAATACCCTCTCTGTCAATGTGGCTCGTTTGCGTAAAAAGTTGGAGGAGCAGGGATTGGTAGGATTTATCGAGA
CCAAGAAAGGAATAGGGTACGGATTGAAGCATGCTTGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (147-221)

3D structure

• AlphaFold DB: Q9S1K2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
braR	Staphylococcus aureus N315	48.624	96.889	0.471
vicR	Streptococcus mutans UA159	35.319	100	0.369