Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   R8566_RS02050 Genome accession   NZ_AP026920
Coordinates   388304..388936 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain PZ900700014     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 383304..393936
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8566_RS02025 (PC0014_03950) mvaD 383581..384534 (+) 954 WP_000373458.1 diphosphomevalonate decarboxylase -
  R8566_RS02030 (PC0014_03960) - 384521..385528 (+) 1008 WP_000562430.1 phosphomevalonate kinase -
  R8566_RS02035 (PC0014_03970) fni 385512..386522 (+) 1011 WP_000210616.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  R8566_RS02040 (PC0014_03980) liaF 386600..387298 (+) 699 WP_001224637.1 cell wall-active antibiotics response protein LiaF -
  R8566_RS02045 (PC0014_03990) - 387295..388290 (+) 996 WP_317642189.1 sensor histidine kinase -
  R8566_RS02050 (PC0014_04000) vraR 388304..388936 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  R8566_RS02055 - 388937..389179 (+) 243 Protein_403 DNA alkylation repair protein -
  R8566_RS02060 - 389104..389706 (+) 603 Protein_404 DNA alkylation repair protein -
  R8566_RS02065 (PC0014_04030) - 389856..390095 (+) 240 WP_000754502.1 hypothetical protein -
  R8566_RS02070 (PC0014_04040) cbpG 390176..391001 (+) 826 Protein_406 choline-binding protein CbpG -
  R8566_RS02075 - 391185..392475 (-) 1291 Protein_407 IS4 family transposase -
  R8566_RS02080 (PC0014_04080) cbpF 392560..393561 (+) 1002 WP_025169441.1 choline-binding protein CbpF -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=82046 R8566_RS02050 WP_000698434.1 388304..388936(+) (vraR) [Streptococcus pneumoniae strain PZ900700014]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=82046 R8566_RS02050 WP_000698434.1 388304..388936(+) (vraR) [Streptococcus pneumoniae strain PZ900700014]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGTTTGGGTTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAACATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41

Multiple sequence alignment