Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   R4700_RS07500 Genome accession   NZ_CP137112
Coordinates   1453037..1453669 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain 02H2025     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1448037..1458669
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4700_RS07475 mvaD 1448314..1449267 (+) 954 WP_000373458.1 diphosphomevalonate decarboxylase -
  R4700_RS07480 - 1449254..1450261 (+) 1008 WP_000562417.1 phosphomevalonate kinase -
  R4700_RS07485 fni 1450245..1451255 (+) 1011 WP_317770853.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  R4700_RS07490 liaF 1451333..1452031 (+) 699 WP_001224634.1 cell wall-active antibiotics response protein LiaF -
  R4700_RS07495 - 1452028..1453023 (+) 996 WP_000743663.1 sensor histidine kinase -
  R4700_RS07500 vraR 1453037..1453669 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  R4700_RS07505 - 1453745..1454428 (+) 684 Protein_1434 DNA alkylation repair protein -
  R4700_RS07510 - 1454578..1454817 (+) 240 WP_000754501.1 hypothetical protein -
  R4700_RS07515 cbpG 1454898..1455488 (+) 591 Protein_1436 choline-binding protein CbpG -
  R4700_RS07520 - 1455844..1456149 (+) 306 WP_001821501.1 tyrosine-type recombinase/integrase -
  R4700_RS07525 tig 1456343..1457626 (+) 1284 WP_000116462.1 trigger factor -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=819904 R4700_RS07500 WP_000698434.1 1453037..1453669(+) (vraR) [Streptococcus pneumoniae strain 02H2025]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=819904 R4700_RS07500 WP_000698434.1 1453037..1453669(+) (vraR) [Streptococcus pneumoniae strain 02H2025]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGATTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCGGATGTTATTGTTATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAACATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTACGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41