Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   R4712_RS01590 Genome accession   NZ_CP137110
Coordinates   323840..326098 (+) Length   752 a.a.
NCBI ID   WP_044812750.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 16H2041     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 318840..331098
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4712_RS01565 - 319749..320621 (-) 873 WP_044812749.1 NAD(P)H-hydrate dehydratase -
  R4712_RS01570 - 320763..321620 (-) 858 WP_000192078.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  R4712_RS01575 - 321774..322508 (-) 735 WP_000140949.1 amino acid ABC transporter ATP-binding protein -
  R4712_RS01580 - 322508..323191 (-) 684 WP_001011637.1 amino acid ABC transporter permease -
  R4712_RS01585 - 323381..323611 (+) 231 WP_000443573.1 YkuJ family protein -
  R4712_RS01590 clpE 323840..326098 (+) 2259 WP_044812750.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  R4712_RS01595 - 326305..327151 (-) 847 Protein_315 IS630 family transposase -
  R4712_RS01600 - 327228..327683 (+) 456 WP_044812859.1 NUDIX hydrolase -
  R4712_RS01605 - 327848..328147 (+) 300 WP_000767195.1 DUF1827 family protein -
  R4712_RS01610 tnpB 328408..328644 (+) 237 WP_000586645.1 IS66 family insertion sequence element accessory protein TnpB -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83867.29 Da        Isoelectric Point: 5.3713

>NTDB_id=819587 R4712_RS01590 WP_044812750.1 323840..326098(+) (clpE) [Streptococcus pneumoniae strain 16H2041]
MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSLFKGMTDLNNRDFDPFGDFFNDLNNFRPSSNTPPIPP
TQSGGGYGGNGGYGSQNRGSAQTPPPSQEKGLLEEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSA
SDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVDETITILKGIQKKYEDYHHVQYTDAA
IEAAATLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRDQIAKYKEM
QKKKITDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKSHVIGQDDAVDKIAKAIRRNRVGLGTPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRHNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKTEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFKALSKDNLLQIVELMLADVNKRLSNNNIRLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDYIEDTITDYYLENP
SEKDLKAVMTSKGNIQIKSAKKAEVKSSEKEK

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=819587 R4712_RS01590 WP_044812750.1 323840..326098(+) (clpE) [Streptococcus pneumoniae strain 16H2041]
ATGCTTTGTCAAAACTGTAAAATTAACGACTCAACAATTCATCTTTACACCAATCTCAATGGAAAACAAAAACAAATTGA
CCTCTGTCAAAACTGCTATAAGATTATCAAAACAGATCCTAACAATAGCCTCTTCAAAGGTATGACGGATCTGAACAATC
GTGACTTCGATCCCTTTGGTGATTTCTTCAATGATCTAAACAATTTCAGACCTTCTAGCAATACTCCTCCTATTCCCCCA
ACCCAATCAGGTGGAGGTTACGGTGGAAACGGCGGTTATGGTTCCCAAAATCGTGGATCTGCTCAAACTCCGCCACCTAG
CCAAGAAAAAGGCCTGCTGGAAGAATTTGGTATTAATGTAACTGAAATTGCCCGTCGTGGAGACATTGACCCCGTTATTG
GGCGCGACGATGAGATTATCCGTGTCATCGAGATTCTCAATCGTAGAACCAAGAATAATCCTGTCCTTATCGGTGAACCT
GGTGTCGGAAAAACGGCCGTTGTCGAAGGTCTAGCTCAGAAAATTGTCGATGGCGATGTGCCACATAAACTCCAAGGTAA
ACAAGTCATCCGTCTGGATGTGGTTAGCTTAGTTCAAGGAACGGGGATTCGAGGACAATTTGAAGAACGCATGCAAAAAC
TCATGGAAGAAATTCGCAAACGTGAAGACATCATCCTCTTTATCGATGAAATCCATGAAATTGTTGGTGCTGGTTCTGCG
AGTGATGGTAATATGGACGCAGGAAATATCCTCAAGCCAGCCCTTGCTCGTGGAGAACTGCAACTAGTCGGTGCTACTAC
CCTCAATGAATACCGTATCATTGAAAAGGATGCTGCCCTCGAGCGTCGTATGCAGCCTGTTAAAGTCGATGAACCAACGG
TGGACGAAACAATCACTATTCTCAAAGGGATTCAAAAGAAATACGAAGATTACCACCACGTTCAATATACAGATGCTGCG
ATTGAAGCAGCTGCAACTCTTTCCAATCGCTACATCCAAGATCGCTTCTTGCCTGACAAGGCCATTGACCTCCTAGATGA
AGCTGGTTCTAAGATGAACTTGACCTTGAATTTTGTGGATCCTAAAGTAATTGATCAGCGCTTGATTGAGGCTGAAAATC
TCAAGTCTCAAGCTACACGAGAAGAAGATTTTGAAAAGGCGGCCTACTTCCGCGACCAGATTGCCAAGTATAAGGAAATG
CAAAAGAAAAAGATCACAGACCAGGATACTCCTATCATCAGCGAGAAAACTATTGAGCACATTATCGAGCAGAAAACCAA
TATCCCTGTTGGTGATTTGAAAGAGAAAGAACAATCTCAACTCATCCATCTAGCCGAAGATCTCAAGTCTCATGTTATTG
GCCAAGATGATGCAGTCGATAAGATTGCCAAGGCTATTCGCCGTAATCGTGTCGGACTTGGTACCCCTAACCGCCCAATC
GGAAGCTTCCTCTTCGTTGGGCCAACTGGTGTCGGTAAGACAGAACTTTCCAAACAACTGGCTATCGAACTTTTTGGTTC
TGCTGATAGTATGATTCGCTTTGATATGAGTGAATACATGGAAAAACATAGTGTGGCTAAGTTGGTCGGCGCCCCTCCAG
GTTATGTTGGCTATGATGAGGCTGGTCAATTAACTGAAAAAGTTCGCCACAATCCATATTCTCTCATCCTTCTCGATGAA
GTGGAAAAAGCTCACCCAGATGTTATGCACATGTTTCTTCAAGTCTTGGACGATGGTCGTTTGACAGACGGGCAAGGACG
CACCGTTAGCTTCAAGGATGCCATCATTATCATGACCTCAAATGCAGGTACAGGAAAGACCGAAGCTAGCGTTGGATTTG
GTGCTGCTAGAGAAGGACGTACCAATTCTGTCCTCGGTGAACTCGGTAACTTCTTTAGCCCAGAGTTTATGAACCGTTTT
GATGGCATTATCGAATTTAAGGCTCTCAGCAAGGATAACCTCCTTCAGATTGTCGAGCTCATGCTAGCAGATGTTAACAA
GCGCCTCTCTAACAACAACATTCGTTTGGATGTAACTGATAAGGTCAAGGAAAAGTTGGTTGACCTAGGTTATGATCCAA
AAATGGGAGCACGCCCACTTCGTCGGACTATTCAAGACTATATTGAGGACACAATCACTGACTACTACCTTGAAAATCCA
AGCGAAAAAGATCTCAAAGCAGTTATGACTAGCAAGGGAAACATTCAGATTAAATCTGCCAAAAAAGCTGAAGTTAAAAG
TTCTGAAAAAGAAAAATAA

Domains

Predicted by InterProScan.

ATPase family associated with various cellular activities (AAA) (AAA)

(155-276)

AAA lid domain (AAA_lid_9)

(293-390)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(649-723)

AAA domain (Cdc48 subfamily) (AAA_2)

(478-641)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

99.867

100

0.999
  clpE Streptococcus pneumoniae D39

99.867

100

0.999
  clpE Streptococcus pneumoniae R6

99.867

100

0.999
  clpE Streptococcus pneumoniae TIGR4

99.734

100

0.997
  clpE Streptococcus mutans UA159

82.731

99.335

0.822
  clpC Lactococcus lactis subsp. cremoris KW2

76.839

97.606

0.75
  clpC Bacillus subtilis subsp. subtilis str. 168

52.308

86.436

0.452
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.687

83.378

0.398
  clpC Streptococcus pneumoniae TIGR4

46.91

83.91

0.394
  clpC Streptococcus pneumoniae Rx1

46.91

83.91

0.394
  clpC Streptococcus pneumoniae D39

46.91

83.91

0.394
  clpC Streptococcus thermophilus LMD-9

46.795

82.979

0.388
  clpC Streptococcus mutans UA159

46.571

83.378

0.388
  clpC Streptococcus thermophilus LMG 18311

46.4

83.112

0.386