Detailed information NTG0819586

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: QAO49_RS10380
• Genome accession: NZ_CP123151
• Coordinates: 2060156..2061505 (+)
• Length: 449 a.a.
• NCBI ID: WP_000815643.1
• Uniprot ID: -
• Organism: Staphylococcus aureus strain GE-MRSA18
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
ICE	2060156..2077519	2060156..2061505	within	0
SCCmec	2054985..2069920	2060156..2061505	within	0

Gene organization within MGE regions

Location: 2054985..2077519

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QAO49_RS10360 (QAO49_10360)	-	2054985..2056139 (-)	1155	WP_000912116.1	ATP-binding protein	-
QAO49_RS10365 (QAO49_10365)	-	2056594..2057640 (+)	1047	WP_001042023.1	hypothetical protein	-
QAO49_RS10370 (QAO49_10370)	ssb	2057833..2058129 (+)	297	WP_000273823.1	cassette chromosome ssDNA-binding protein	-
QAO49_RS10375 (QAO49_10375)	cch1	2058129..2059922 (+)	1794	WP_000079474.1	cassette chromosome replicative helicase	-
QAO49_RS10380 (QAO49_10380)	ccrA	2060156..2061505 (+)	1350	WP_000815643.1	cassette chromosome recombinase CcrA	Machinery gene
QAO49_RS10385 (QAO49_10385)	ccrB	2061527..2063155 (+)	1629	WP_001186605.1	cassette chromosome recombinase CcrB	Machinery gene
QAO49_RS10390 (QAO49_10390)	-	2063677..2064027 (+)	351	WP_000849672.1	SAUGI family uracil-DNA glycosylase inhibitor	-
QAO49_RS10395 (QAO49_10395)	-	2064114..2064425 (+)	312	WP_000700851.1	DUF960 family protein	-
QAO49_RS10400 (QAO49_10400)	-	2064440..2064946 (+)	507	WP_001092189.1	DUF1643 domain-containing protein	-
QAO49_RS10405 (QAO49_10405)	-	2064995..2066605 (+)	1611	Protein_2014	IS1182 family transposase	-
QAO49_RS10410 (QAO49_10410)	-	2066596..2066838 (-)	243	Protein_2015	type I restriction enzyme endonuclease domain-containing protein	-
QAO49_RS10415 (QAO49_10415)	-	2066828..2067814 (-)	987	WP_001549960.1	beta-lactam sensor/signal transducer MecR1	-
QAO49_RS10420 (QAO49_10420)	mecA	2067911..2069920 (+)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-
QAO49_RS10425 (QAO49_10425)	-	2069966..2070394 (-)	429	WP_000872606.1	MaoC family dehydratase	-
QAO49_RS10430 (QAO49_10430)	-	2070491..2071234 (-)	744	WP_000958858.1	glycerophosphoryl diester phosphodiesterase	-
QAO49_RS10435 (QAO49_10435)	-	2071499..2072173 (+)	675	WP_001106057.1	IS6-like element IS257 family transposase	-
QAO49_RS10440 (QAO49_10440)	aadD1	2072366..2073136 (+)	771	WP_001795128.1	aminoglycoside O-nucleotidyltransferase ANT(4')-Ia	-
QAO49_RS10445 (QAO49_10445)	bleO	2073353..2073757 (+)	405	WP_001242578.1	bleomycin binding protein	-
QAO49_RS10450 (QAO49_10450)	mobV	2074264..2075526 (+)	1263	WP_000119405.1	MobV family relaxase	-
QAO49_RS10455 (QAO49_10455)	-	2075771..2076754 (+)	984	Protein_2024	protein rep	-
QAO49_RS10460 (QAO49_10460)	-	2076845..2077519 (+)	675	WP_001106057.1	IS6-like element IS257 family transposase	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52546.19 Da
• Isoelectric Point: 9.9953

>NTDB_id=819586 QAO49_RS10380 WP_000815643.1 2060156..2061505(+) (ccrA) [Staphylococcus aureus strain GE-MRSA18]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQLTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYDYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQTKQTSSDNQLKQKIKCPCCNATLTNMTVRKKNHILRYYVCPKNMNASRFVCDFKGINAQTLEDKVLKV
CQDFYQDQHIYVKIKNAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFRKQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQAMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=819586 QAO49_RS10380 WP_000815643.1 2060156..2061505(+) (ccrA) [Staphylococcus aureus strain GE-MRSA18]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAATTAACACAATTAATTCAACAAGGACAATGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGATTATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGCCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAACCAAACAGACATCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCGTTAGAAAAAAGAATCATATATTACGTTACTACGTCTGTCCTA
AAAATATGAATGCTTCACGCTTTGTCTGTGATTTCAAAGGCATCAATGCACAGACATTGGAAGATAAAGTATTAAAAGTG
TGCCAAGACTTTTATCAAGACCAACATATCTACGTAAAAATTAAAAATGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAGCATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTTA
GAAAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATAAATGGGCATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAGCCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (169-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-322)

• Resolvase, N terminal domain (Resolvase) (4-147)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	96.659	100	0.967
ccrA	Staphylococcus aureus COL	74.61	100	0.746