Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   R8613_RS02130 Genome accession   NZ_AP026919
Coordinates   393519..394151 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain PZ900700012     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 388519..399151
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8613_RS02105 (PC0012_03980) mvaD 388796..389749 (+) 954 WP_000373461.1 diphosphomevalonate decarboxylase -
  R8613_RS02110 (PC0012_03990) - 389736..390743 (+) 1008 WP_000562417.1 phosphomevalonate kinase -
  R8613_RS02115 (PC0012_04000) fni 390727..391737 (+) 1011 WP_219565697.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  R8613_RS02120 (PC0012_04010) liaF 391815..392513 (+) 699 WP_219565696.1 cell wall-active antibiotics response protein LiaF -
  R8613_RS02125 (PC0012_04020) - 392510..393505 (+) 996 WP_219565695.1 sensor histidine kinase -
  R8613_RS02130 (PC0012_04030) vraR 393519..394151 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  R8613_RS02135 - 394227..394921 (+) 695 Protein_419 DNA alkylation repair protein -
  R8613_RS02140 (PC0012_04060) - 395071..395310 (+) 240 WP_000754501.1 hypothetical protein -
  R8613_RS02145 (PC0012_04070) cbpG 395391..396212 (+) 822 WP_061816995.1 choline-binding protein CbpG -
  R8613_RS02150 (PC0012_04080) cbpF 396231..397253 (+) 1023 Protein_422 choline-binding protein CbpF -
  R8613_RS02155 (PC0012_04100) - 397379..398650 (-) 1272 Protein_423 IS3 family transposase -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=81925 R8613_RS02130 WP_000698434.1 393519..394151(+) (vraR) [Streptococcus pneumoniae strain PZ900700012]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=81925 R8613_RS02130 WP_000698434.1 393519..394151(+) (vraR) [Streptococcus pneumoniae strain PZ900700012]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGTTTGGGTTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAACATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41

Multiple sequence alignment