Detailed information    

insolico Bioinformatically predicted

Overview

Name   braR   Type   Regulator
Locus tag   R4708_RS08785 Genome accession   NZ_CP137104
Coordinates   1695590..1696267 (+) Length   225 a.a.
NCBI ID   WP_000548959.1    Uniprot ID   Q9S1K2
Organism   Streptococcus pneumoniae strain LM     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1690590..1701267
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4708_RS11215 - 1690737..1690808 (-) 72 Protein_1683 glutamine ABC transporter permease -
  R4708_RS08750 - 1690939..1691585 (-) 647 Protein_1684 nicotinamide mononucleotide transporter -
  R4708_RS08755 - 1691611..1691802 (-) 192 WP_001816503.1 hypothetical protein -
  R4708_RS08760 - 1691783..1692433 (-) 651 WP_000188505.1 metal-dependent transcriptional regulator -
  R4708_RS08765 - 1692545..1693387 (+) 843 WP_000160938.1 metallophosphoesterase -
  R4708_RS08770 - 1693463..1693900 (+) 438 WP_001166785.1 Rrf2 family transcriptional regulator -
  R4708_RS08775 - 1693968..1694270 (+) 303 WP_000281609.1 hypothetical protein -
  R4708_RS08780 - 1694361..1695434 (-) 1074 WP_001273823.1 DUF2974 domain-containing protein -
  R4708_RS08785 braR 1695590..1696267 (+) 678 WP_000548959.1 response regulator transcription factor Regulator
  R4708_RS08790 - 1696260..1697234 (+) 975 WP_000887953.1 HAMP domain-containing histidine kinase -
  R4708_RS08795 thrS 1697283..1699226 (-) 1944 WP_000608349.1 threonine--tRNA ligase -
  R4708_RS08800 - 1699284..1699460 (-) 177 WP_000166031.1 MazG-like protein -
  R4708_RS08805 - 1699467..1699607 (-) 141 WP_000422775.1 MazG-like protein -
  R4708_RS08810 - 1700037..1700237 (-) 201 WP_001814296.1 hypothetical protein -
  R4708_RS08815 - 1700475..1701104 (+) 630 WP_000762091.1 NAD(P)-dependent oxidoreductase -

Sequence

Protein


Download         Length: 225 a.a.        Molecular weight: 25964.16 Da        Isoelectric Point: 5.1362

>NTDB_id=818958 R4708_RS08785 WP_000548959.1 1695590..1696267(+) (braR) [Streptococcus pneumoniae strain LM]
MHKILLIEDDQVIRQQIGKMLSEWGFEVVLVEDFMEVLSLFVQSEPHLVLMDIGLPLFNGYHWCQEIRKISKVPIMFLSS
RDQAMDIVMAINMGADDFVTKPFDQQVLLAKVQGLLRRSYEFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQIL
RVLFEHAGNIVARDDLMRELWNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGIGYGLKHA

Nucleotide


Download         Length: 678 bp        

>NTDB_id=818958 R4708_RS08785 WP_000548959.1 1695590..1696267(+) (braR) [Streptococcus pneumoniae strain LM]
ATGCACAAGATTTTATTAATAGAAGATGATCAGGTCATTCGTCAACAGATTGGGAAAATGCTCTCTGAATGGGGATTTGA
AGTGGTCCTGGTAGAAGACTTTATGGAAGTTTTGAGTCTATTTGTTCAGTCGGAACCTCATCTGGTCCTCATGGATATTG
GTTTGCCCTTGTTTAATGGTTATCACTGGTGTCAGGAAATCCGCAAGATTTCCAAGGTACCTATCATGTTTCTTTCTTCG
AGAGACCAGGCTATGGATATTGTCATGGCAATCAATATGGGGGCGGATGACTTTGTGACCAAGCCTTTTGACCAGCAGGT
TCTTTTAGCTAAGGTTCAGGGCTTGTTGCGTCGTTCCTATGAGTTTGGGCGTGATGAGAGTTTGCTGGAATATGCTGGTG
TTATCCTCAATACCAAATCCATGGATTTACATTATCAAGGGCAAGTCTTGAATTTGACCAAGAATGAATTCCAGATTTTA
CGCGTGTTATTTGAGCATGCAGGCAACATCGTAGCACGTGACGACCTGATGCGGGAACTTTGGAACAGTGACTTTTTCAT
TGATGATAATACCCTCTCTGTCAATGTGGCTCGTTTGCGTAAAAAGTTGGAGGAGCAGGGATTGGTAGGATTTATCGAGA
CCAAGAAAGGAATAGGGTACGGATTGAAGCATGCTTGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(147-221)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1K2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  braR Staphylococcus aureus N315

48.624

96.889

0.471
  vicR Streptococcus mutans UA159

35.319

100

0.369