Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrB   Type   Machinery gene
Locus tag   QAY62_RS10060 Genome accession   NZ_CP123097
Coordinates   2055554..2057182 (+) Length   542 a.a.
NCBI ID   WP_001186602.1    Uniprot ID   Q9XB94
Organism   Staphylococcus aureus strain MRSA-ATCC43300     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 2054183..2075548 2055554..2057182 within 0


Gene organization within MGE regions


Location: 2054183..2075548
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QAY62_RS10055 (QAY62_10040) ccrA 2054183..2055532 (+) 1350 WP_000815646.1 cassette chromosome recombinase CcrA Machinery gene
  QAY62_RS10060 (QAY62_10045) ccrB 2055554..2057182 (+) 1629 WP_001186602.1 cassette chromosome recombinase CcrB Machinery gene
  QAY62_RS10065 (QAY62_10050) - 2057700..2058050 (+) 351 WP_000859155.1 SAUGI family uracil-DNA glycosylase inhibitor -
  QAY62_RS10070 (QAY62_10055) - 2058137..2058448 (+) 312 WP_000700853.1 DUF960 family protein -
  QAY62_RS10075 (QAY62_10060) - 2058466..2058972 (+) 507 WP_001092169.1 DUF1643 domain-containing protein -
  QAY62_RS10080 (QAY62_10065) - 2058993..2059310 (+) 318 WP_000659050.1 JAB domain-containing protein -
  QAY62_RS10085 (QAY62_10070) - 2059429..2060514 (+) 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
  QAY62_RS10090 (QAY62_10075) - 2060511..2062403 (+) 1893 WP_001557544.1 site-specific integrase -
  QAY62_RS10095 (QAY62_10080) - 2062410..2062787 (+) 378 WP_000361059.1 DUF6262 family protein -
  QAY62_RS10100 (QAY62_10085) - 2062938..2063720 (+) 783 WP_000067268.1 aminoglycoside nucleotidyltransferase ANT(9)-Ia -
  QAY62_RS10105 (QAY62_10090) erm(A) 2063846..2064577 (-) 732 WP_001072201.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  QAY62_RS10110 - 2064660..2064719 (-) 60 WP_010959190.1 erythromycin resistance leader peptide -
  QAY62_RS10115 (QAY62_10095) - 2065111..2065773 (+) 663 WP_001092058.1 class I SAM-dependent methyltransferase -
  QAY62_RS10120 (QAY62_10100) - 2066118..2066756 (-) 639 Protein_1959 sulfite exporter TauE/SafE family protein -
  QAY62_RS10125 (QAY62_10105) cstR 2066756..2067016 (-) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  QAY62_RS10130 (QAY62_10110) - 2067152..2068216 (+) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  QAY62_RS10135 (QAY62_10115) cstB 2068249..2069583 (+) 1335 Protein_1962 persulfide dioxygenase-sulfurtransferase CstB -
  QAY62_RS10140 (QAY62_10120) - 2069697..2070806 (-) 1110 WP_000943131.1 ROK family transcriptional regulator -
  QAY62_RS10145 (QAY62_10125) psm-mec 2071161..2071229 (+) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  QAY62_RS10150 (QAY62_10130) mecI 2071314..2071685 (-) 372 WP_000369214.1 mecA-type methicillin resistance repressor MecI -
  QAY62_RS10155 (QAY62_10135) mecR1 2071685..2073442 (-) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  QAY62_RS10160 (QAY62_10140) mecA 2073539..2075548 (+) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -

Sequence

Protein


Download         Length: 542 a.a.        Molecular weight: 62664.84 Da        Isoelectric Point: 9.8600

>NTDB_id=818659 QAY62_RS10060 WP_001186602.1 2055554..2057182(+) (ccrB) [Staphylococcus aureus strain MRSA-ATCC43300]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKEGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKPLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI

Nucleotide


Download         Length: 1629 bp        

>NTDB_id=818659 QAY62_RS10060 WP_001186602.1 2055554..2057182(+) (ccrB) [Staphylococcus aureus strain MRSA-ATCC43300]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGAAGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTATCAGAGCGTATGGAAGTCAATACTTCATCGGGTAAGCTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGCCATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTTAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGCCTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATAAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG

Domains

Predicted by InterproScan.

Ogr/Delta-like zinc finger (Ogr_Delta)

(301-356)

Resolvase, N terminal domain (Resolvase)

(11-156)

Recombinase (Recombinase)

(180-280)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9XB94

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrB Staphylococcus aureus N315

100

100

1